Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide

It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conven...
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Autor*in:	Young-Dan Cho [verfasserIn] Ji-Cheol Shin [verfasserIn] Hyung-In Yoon [verfasserIn] Young Ku [verfasserIn] Hyun-Mo Ryoo [verfasserIn] Dae-Joon Kim [verfasserIn] Do-Gyoon Kim [verfasserIn] Jung-Suk Han [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing

Übergeordnetes Werk:	In: Materials - MDPI AG, 2009, 8(2015), 9, Seite 6018-6028
Übergeordnetes Werk:	volume:8 ; year:2015 ; number:9 ; pages:6018-6028

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ma8095288

Katalog-ID:	DOAJ033451893

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allfields	10.3390/ma8095288 doi (DE-627)DOAJ033451893 (DE-599)DOAJ3caef51475fe43a8b490f350165d7c72 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Young-Dan Cho verfasserin aut Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome. dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Ji-Cheol Shin verfasserin aut Hyung-In Yoon verfasserin aut Young Ku verfasserin aut Hyun-Mo Ryoo verfasserin aut Dae-Joon Kim verfasserin aut Do-Gyoon Kim verfasserin aut Jung-Suk Han verfasserin aut In Materials MDPI AG, 2009 8(2015), 9, Seite 6018-6028 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:8 year:2015 number:9 pages:6018-6028 https://doi.org/10.3390/ma8095288 kostenfrei https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 kostenfrei http://www.mdpi.com/1996-1944/8/9/5288 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 9 6018-6028
spelling	10.3390/ma8095288 doi (DE-627)DOAJ033451893 (DE-599)DOAJ3caef51475fe43a8b490f350165d7c72 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Young-Dan Cho verfasserin aut Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome. dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Ji-Cheol Shin verfasserin aut Hyung-In Yoon verfasserin aut Young Ku verfasserin aut Hyun-Mo Ryoo verfasserin aut Dae-Joon Kim verfasserin aut Do-Gyoon Kim verfasserin aut Jung-Suk Han verfasserin aut In Materials MDPI AG, 2009 8(2015), 9, Seite 6018-6028 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:8 year:2015 number:9 pages:6018-6028 https://doi.org/10.3390/ma8095288 kostenfrei https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 kostenfrei http://www.mdpi.com/1996-1944/8/9/5288 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 9 6018-6028
allfields_unstemmed	10.3390/ma8095288 doi (DE-627)DOAJ033451893 (DE-599)DOAJ3caef51475fe43a8b490f350165d7c72 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Young-Dan Cho verfasserin aut Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome. dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Ji-Cheol Shin verfasserin aut Hyung-In Yoon verfasserin aut Young Ku verfasserin aut Hyun-Mo Ryoo verfasserin aut Dae-Joon Kim verfasserin aut Do-Gyoon Kim verfasserin aut Jung-Suk Han verfasserin aut In Materials MDPI AG, 2009 8(2015), 9, Seite 6018-6028 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:8 year:2015 number:9 pages:6018-6028 https://doi.org/10.3390/ma8095288 kostenfrei https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 kostenfrei http://www.mdpi.com/1996-1944/8/9/5288 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 9 6018-6028
allfieldsGer	10.3390/ma8095288 doi (DE-627)DOAJ033451893 (DE-599)DOAJ3caef51475fe43a8b490f350165d7c72 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Young-Dan Cho verfasserin aut Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome. dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Ji-Cheol Shin verfasserin aut Hyung-In Yoon verfasserin aut Young Ku verfasserin aut Hyun-Mo Ryoo verfasserin aut Dae-Joon Kim verfasserin aut Do-Gyoon Kim verfasserin aut Jung-Suk Han verfasserin aut In Materials MDPI AG, 2009 8(2015), 9, Seite 6018-6028 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:8 year:2015 number:9 pages:6018-6028 https://doi.org/10.3390/ma8095288 kostenfrei https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 kostenfrei http://www.mdpi.com/1996-1944/8/9/5288 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 9 6018-6028
allfieldsSound	10.3390/ma8095288 doi (DE-627)DOAJ033451893 (DE-599)DOAJ3caef51475fe43a8b490f350165d7c72 DE-627 ger DE-627 rakwb eng TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Young-Dan Cho verfasserin aut Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome. dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics Ji-Cheol Shin verfasserin aut Hyung-In Yoon verfasserin aut Young Ku verfasserin aut Hyun-Mo Ryoo verfasserin aut Dae-Joon Kim verfasserin aut Do-Gyoon Kim verfasserin aut Jung-Suk Han verfasserin aut In Materials MDPI AG, 2009 8(2015), 9, Seite 6018-6028 (DE-627)595712649 (DE-600)2487261-1 19961944 nnns volume:8 year:2015 number:9 pages:6018-6028 https://doi.org/10.3390/ma8095288 kostenfrei https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 kostenfrei http://www.mdpi.com/1996-1944/8/9/5288 kostenfrei https://doaj.org/toc/1996-1944 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 9 6018-6028
language	English
source	In Materials 8(2015), 9, Seite 6018-6028 volume:8 year:2015 number:9 pages:6018-6028
sourceStr	In Materials 8(2015), 9, Seite 6018-6028 volume:8 year:2015 number:9 pages:6018-6028
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing Technology T Electrical engineering. Electronics. Nuclear engineering Engineering (General). Civil engineering (General) Microscopy Descriptive and experimental mechanics
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container_title	Materials
authorswithroles_txt_mv	Young-Dan Cho @@aut@@ Ji-Cheol Shin @@aut@@ Hyung-In Yoon @@aut@@ Young Ku @@aut@@ Hyun-Mo Ryoo @@aut@@ Dae-Joon Kim @@aut@@ Do-Gyoon Kim @@aut@@ Jung-Suk Han @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	595712649
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language_de	englisch
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callnumber-first	T - Technology
author	Young-Dan Cho
spellingShingle	Young-Dan Cho misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc dental implant misc zirconia misc niobium misc human gingival fibroblasts (HGFs) misc mucosal sealing misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide
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topic_title	TK1-9971 TA1-2040 QH201-278.5 QC120-168.85 Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide dental implant zirconia niobium human gingival fibroblasts (HGFs) mucosal sealing
topic	misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc dental implant misc zirconia misc niobium misc human gingival fibroblasts (HGFs) misc mucosal sealing misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics
topic_unstemmed	misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc dental implant misc zirconia misc niobium misc human gingival fibroblasts (HGFs) misc mucosal sealing misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics
topic_browse	misc TK1-9971 misc TA1-2040 misc QH201-278.5 misc QC120-168.85 misc dental implant misc zirconia misc niobium misc human gingival fibroblasts (HGFs) misc mucosal sealing misc Technology misc T misc Electrical engineering. Electronics. Nuclear engineering misc Engineering (General). Civil engineering (General) misc Microscopy misc Descriptive and experimental mechanics
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title	Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide
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title_full	Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide
author_sort	Young-Dan Cho
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author_browse	Young-Dan Cho Ji-Cheol Shin Hyung-In Yoon Young Ku Hyun-Mo Ryoo Dae-Joon Kim Do-Gyoon Kim Jung-Suk Han
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title_sort	characterization of human gingival fibroblasts on zirconia surfaces containing niobium oxide
callnumber	TK1-9971
title_auth	Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide
abstract	It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome.
abstractGer	It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome.
abstract_unstemmed	It was indicated that tetragonal zirconia polycrystal (TZP) containing yttria (Y2O3) and niobium oxide (Nb2O5) ((Y,Nb)-TZP) could be an adequate dental material to be used at esthetically important sites. The (Y,Nb)-TZP was also proved to possess its osteogenic potential comparable with those conventional dental implant material, titanium (Ti). The objective of the current study was to characterize cellular response of human gingival fibroblasts (HGFs) to smooth and rough surfaces of the (Y,Nb)-TZP disc, which were obtained by polishing and sandblasting, respectively. Various microscopic, biochemical, and molecular techniques were used to investigate the disc surfaces and cellular responses for the experimental (Y,Nb)-TZP and the comparing Ti groups. Sandblasted rough (Y,Nb)-TZP (Zir-R) discs had the highest surface roughness. HGFs cultured on polished (Y,Nb)-TZP (Zir) showed a rounded cell morphology and light spreading at 6 h after seeding and its proliferation rate significantly increased during seven days of culture compared to other surfaces. The mRNA expressions of type I collagen, integrin α2 and β1 were significantly stimulated for the Zir group at 24 h after seeding. The current findings, combined with the previous results, indicate that (Y,Nb)-TZP provides appropriate surface condition for osseointegration at the fixture level and for peri-implant mucosal sealing at the abutment level producing a suitable candidate for dental implantation with an expected favorable clinical outcome.
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title_short	Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide
url	https://doi.org/10.3390/ma8095288 https://doaj.org/article/3caef51475fe43a8b490f350165d7c72 http://www.mdpi.com/1996-1944/8/9/5288 https://doaj.org/toc/1996-1944
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Characterization of Human Gingival Fibroblasts on Zirconia Surfaces Containing Niobium Oxide

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