Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?

Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was e...
Ausführliche Beschreibung

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Autor*in:	Michael Rehling [verfasserIn] Stine Gram Skjøth [verfasserIn] Jørgen Frøkiær [verfasserIn] Lene Elsebeth Nielsen [verfasserIn] Christian Flø [verfasserIn] Bente Jespersen [verfasserIn] Anna Krarup Keller [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts

Übergeordnetes Werk:	In: BMC Nephrology - BMC, 2003, 23(2022), 1, Seite 5
Übergeordnetes Werk:	volume:23 ; year:2022 ; number:1 ; pages:5

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12882-022-02780-0

Katalog-ID:	DOAJ033475989

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520			\|a Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli.
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700	0		\|a Anna Krarup Keller \|e verfasserin \|4 aut
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allfields	10.1186/s12882-022-02780-0 doi (DE-627)DOAJ033475989 (DE-599)DOAJ3cdc0770b5984154a3deaea17468b7c2 DE-627 ger DE-627 rakwb eng RC870-923 Michael Rehling verfasserin aut Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli. Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts Diseases of the genitourinary system. Urology Stine Gram Skjøth verfasserin aut Jørgen Frøkiær verfasserin aut Lene Elsebeth Nielsen verfasserin aut Christian Flø verfasserin aut Bente Jespersen verfasserin aut Anna Krarup Keller verfasserin aut In BMC Nephrology BMC, 2003 23(2022), 1, Seite 5 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:23 year:2022 number:1 pages:5 https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 kostenfrei https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 5
spelling	10.1186/s12882-022-02780-0 doi (DE-627)DOAJ033475989 (DE-599)DOAJ3cdc0770b5984154a3deaea17468b7c2 DE-627 ger DE-627 rakwb eng RC870-923 Michael Rehling verfasserin aut Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli. Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts Diseases of the genitourinary system. Urology Stine Gram Skjøth verfasserin aut Jørgen Frøkiær verfasserin aut Lene Elsebeth Nielsen verfasserin aut Christian Flø verfasserin aut Bente Jespersen verfasserin aut Anna Krarup Keller verfasserin aut In BMC Nephrology BMC, 2003 23(2022), 1, Seite 5 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:23 year:2022 number:1 pages:5 https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 kostenfrei https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 5
allfields_unstemmed	10.1186/s12882-022-02780-0 doi (DE-627)DOAJ033475989 (DE-599)DOAJ3cdc0770b5984154a3deaea17468b7c2 DE-627 ger DE-627 rakwb eng RC870-923 Michael Rehling verfasserin aut Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli. Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts Diseases of the genitourinary system. Urology Stine Gram Skjøth verfasserin aut Jørgen Frøkiær verfasserin aut Lene Elsebeth Nielsen verfasserin aut Christian Flø verfasserin aut Bente Jespersen verfasserin aut Anna Krarup Keller verfasserin aut In BMC Nephrology BMC, 2003 23(2022), 1, Seite 5 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:23 year:2022 number:1 pages:5 https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 kostenfrei https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 5
allfieldsGer	10.1186/s12882-022-02780-0 doi (DE-627)DOAJ033475989 (DE-599)DOAJ3cdc0770b5984154a3deaea17468b7c2 DE-627 ger DE-627 rakwb eng RC870-923 Michael Rehling verfasserin aut Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli. Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts Diseases of the genitourinary system. Urology Stine Gram Skjøth verfasserin aut Jørgen Frøkiær verfasserin aut Lene Elsebeth Nielsen verfasserin aut Christian Flø verfasserin aut Bente Jespersen verfasserin aut Anna Krarup Keller verfasserin aut In BMC Nephrology BMC, 2003 23(2022), 1, Seite 5 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:23 year:2022 number:1 pages:5 https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 kostenfrei https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 5
allfieldsSound	10.1186/s12882-022-02780-0 doi (DE-627)DOAJ033475989 (DE-599)DOAJ3cdc0770b5984154a3deaea17468b7c2 DE-627 ger DE-627 rakwb eng RC870-923 Michael Rehling verfasserin aut Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli. Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts Diseases of the genitourinary system. Urology Stine Gram Skjøth verfasserin aut Jørgen Frøkiær verfasserin aut Lene Elsebeth Nielsen verfasserin aut Christian Flø verfasserin aut Bente Jespersen verfasserin aut Anna Krarup Keller verfasserin aut In BMC Nephrology BMC, 2003 23(2022), 1, Seite 5 (DE-627)326643672 (DE-600)2041348-8 14712369 nnns volume:23 year:2022 number:1 pages:5 https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 kostenfrei https://doi.org/10.1186/s12882-022-02780-0 kostenfrei https://doaj.org/toc/1471-2369 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2022 1 5
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We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. 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callnumber-first	R - Medicine
author	Michael Rehling
spellingShingle	Michael Rehling misc RC870-923 misc Microspheres misc Renal blood flow misc Renal ischaemia misc Renal perfusion misc Renal redistribution misc Renal shunts misc Diseases of the genitourinary system. Urology Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
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topic_title	RC870-923 Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney? Microspheres Renal blood flow Renal ischaemia Renal perfusion Renal redistribution Renal shunts
topic	misc RC870-923 misc Microspheres misc Renal blood flow misc Renal ischaemia misc Renal perfusion misc Renal redistribution misc Renal shunts misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Microspheres misc Renal blood flow misc Renal ischaemia misc Renal perfusion misc Renal redistribution misc Renal shunts misc Diseases of the genitourinary system. Urology
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title	Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
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title_full	Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
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author_browse	Michael Rehling Stine Gram Skjøth Jørgen Frøkiær Lene Elsebeth Nielsen Christian Flø Bente Jespersen Anna Krarup Keller
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title_sort	corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
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title_auth	Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
abstract	Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli.
abstractGer	Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli.
abstract_unstemmed	Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli.
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title_short	Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
url	https://doi.org/10.1186/s12882-022-02780-0 https://doaj.org/article/3cdc0770b5984154a3deaea17468b7c2 https://doaj.org/toc/1471-2369
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author2	Stine Gram Skjøth Jørgen Frøkiær Lene Elsebeth Nielsen Christian Flø Bente Jespersen Anna Krarup Keller
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up_date	2024-07-03T17:57:34.467Z
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