A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections

Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of cha...
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Autor*in:	Erin T. Livingston [verfasserIn] Md Huzzatul Mursalin [verfasserIn] Michelle C. Callegan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	polymorphonuclear leukocytes neutrophils innate immunity bacteria keratitis conjunctivitis endophthalmitis uveitis

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 7(2019), 11, p 537
Übergeordnetes Werk:	volume:7 ; year:2019 ; number:11, p 537

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms7110537

Katalog-ID:	DOAJ033486425

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spelling	10.3390/microorganisms7110537 doi (DE-627)DOAJ033486425 (DE-599)DOAJad879f9216e64ac0a52a074954d2639e DE-627 ger DE-627 rakwb eng QH301-705.5 Erin T. Livingston verfasserin aut A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Interestingly, the PMN response from the host seems to be necessary for pathogen clearance in ocular disease, but the inflammatory response can also be detrimental to vision retention. This “Pyrrhic Victory” scenario is explored in each type of ocular infection, with details on PMN recruitment and response at the site of ocular infection. In addition, we emphasize the differences in PMN responses between each ocular disease and its most common corresponding bacterial pathogen. The in vitro and animal models used to identify PMN responses, such as recruitment, phagocytosis, degranulation, and NETosis, are also outlined in each ocular infection. This detailed study of the ocular acute immune response to infection could provide novel therapeutic strategies for blinding diseases, provide more general information on ocular PMN responses, and reveal areas of bacterial ocular infection research that lack PMN response studies. polymorphonuclear leukocytes neutrophils innate immunity bacteria keratitis conjunctivitis endophthalmitis uveitis Biology (General) Md Huzzatul Mursalin verfasserin aut Michelle C. Callegan verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 537 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 537 https://doi.org/10.3390/microorganisms7110537 kostenfrei https://doaj.org/article/ad879f9216e64ac0a52a074954d2639e kostenfrei https://www.mdpi.com/2076-2607/7/11/537 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 537
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allfieldsSound	10.3390/microorganisms7110537 doi (DE-627)DOAJ033486425 (DE-599)DOAJad879f9216e64ac0a52a074954d2639e DE-627 ger DE-627 rakwb eng QH301-705.5 Erin T. Livingston verfasserin aut A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Interestingly, the PMN response from the host seems to be necessary for pathogen clearance in ocular disease, but the inflammatory response can also be detrimental to vision retention. This “Pyrrhic Victory” scenario is explored in each type of ocular infection, with details on PMN recruitment and response at the site of ocular infection. In addition, we emphasize the differences in PMN responses between each ocular disease and its most common corresponding bacterial pathogen. The in vitro and animal models used to identify PMN responses, such as recruitment, phagocytosis, degranulation, and NETosis, are also outlined in each ocular infection. This detailed study of the ocular acute immune response to infection could provide novel therapeutic strategies for blinding diseases, provide more general information on ocular PMN responses, and reveal areas of bacterial ocular infection research that lack PMN response studies. polymorphonuclear leukocytes neutrophils innate immunity bacteria keratitis conjunctivitis endophthalmitis uveitis Biology (General) Md Huzzatul Mursalin verfasserin aut Michelle C. Callegan verfasserin aut In Microorganisms MDPI AG, 2013 7(2019), 11, p 537 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:7 year:2019 number:11, p 537 https://doi.org/10.3390/microorganisms7110537 kostenfrei https://doaj.org/article/ad879f9216e64ac0a52a074954d2639e kostenfrei https://www.mdpi.com/2076-2607/7/11/537 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2019 11, p 537
language	English
source	In Microorganisms 7(2019), 11, p 537 volume:7 year:2019 number:11, p 537
sourceStr	In Microorganisms 7(2019), 11, p 537 volume:7 year:2019 number:11, p 537
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institution	findex.gbv.de
topic_facet	polymorphonuclear leukocytes neutrophils innate immunity bacteria keratitis conjunctivitis endophthalmitis uveitis Biology (General)
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container_title	Microorganisms
authorswithroles_txt_mv	Erin T. Livingston @@aut@@ Md Huzzatul Mursalin @@aut@@ Michelle C. Callegan @@aut@@
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Livingston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. 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author	Erin T. Livingston
spellingShingle	Erin T. Livingston misc QH301-705.5 misc polymorphonuclear leukocytes misc neutrophils misc innate immunity misc bacteria misc keratitis misc conjunctivitis misc endophthalmitis misc uveitis misc Biology (General) A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections
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topic_title	QH301-705.5 A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections polymorphonuclear leukocytes neutrophils innate immunity bacteria keratitis conjunctivitis endophthalmitis uveitis
topic	misc QH301-705.5 misc polymorphonuclear leukocytes misc neutrophils misc innate immunity misc bacteria misc keratitis misc conjunctivitis misc endophthalmitis misc uveitis misc Biology (General)
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title	A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections
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title_auth	A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections
abstract	Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Interestingly, the PMN response from the host seems to be necessary for pathogen clearance in ocular disease, but the inflammatory response can also be detrimental to vision retention. This “Pyrrhic Victory” scenario is explored in each type of ocular infection, with details on PMN recruitment and response at the site of ocular infection. In addition, we emphasize the differences in PMN responses between each ocular disease and its most common corresponding bacterial pathogen. The in vitro and animal models used to identify PMN responses, such as recruitment, phagocytosis, degranulation, and NETosis, are also outlined in each ocular infection. This detailed study of the ocular acute immune response to infection could provide novel therapeutic strategies for blinding diseases, provide more general information on ocular PMN responses, and reveal areas of bacterial ocular infection research that lack PMN response studies.
abstractGer	Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Interestingly, the PMN response from the host seems to be necessary for pathogen clearance in ocular disease, but the inflammatory response can also be detrimental to vision retention. This “Pyrrhic Victory” scenario is explored in each type of ocular infection, with details on PMN recruitment and response at the site of ocular infection. In addition, we emphasize the differences in PMN responses between each ocular disease and its most common corresponding bacterial pathogen. The in vitro and animal models used to identify PMN responses, such as recruitment, phagocytosis, degranulation, and NETosis, are also outlined in each ocular infection. This detailed study of the ocular acute immune response to infection could provide novel therapeutic strategies for blinding diseases, provide more general information on ocular PMN responses, and reveal areas of bacterial ocular infection research that lack PMN response studies.
abstract_unstemmed	Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or when an aberrant response occurs in the face of challenge. In this review, we highlight the role of the PMN (polymorphonuclear leukocyte) in different bacterial ocular infections that invade the immune privileged eye at the anterior and posterior segments: keratitis, conjunctivitis, uveitis, and endophthalmitis. Interestingly, the PMN response from the host seems to be necessary for pathogen clearance in ocular disease, but the inflammatory response can also be detrimental to vision retention. This “Pyrrhic Victory” scenario is explored in each type of ocular infection, with details on PMN recruitment and response at the site of ocular infection. In addition, we emphasize the differences in PMN responses between each ocular disease and its most common corresponding bacterial pathogen. The in vitro and animal models used to identify PMN responses, such as recruitment, phagocytosis, degranulation, and NETosis, are also outlined in each ocular infection. This detailed study of the ocular acute immune response to infection could provide novel therapeutic strategies for blinding diseases, provide more general information on ocular PMN responses, and reveal areas of bacterial ocular infection research that lack PMN response studies.
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