Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia
Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its r...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Junki Sakata [verfasserIn] Ryoji Yoshida [verfasserIn] Yuichiro Matsuoka [verfasserIn] Masashi Nagata [verfasserIn] Akiyuki Hirosue [verfasserIn] Kenta Kawahara [verfasserIn] Takuya Nakamura [verfasserIn] Masafumi Nakamoto [verfasserIn] Masatoshi Hirayama [verfasserIn] Nozomu Takahashi [verfasserIn] Hikaru Nakashima [verfasserIn] Hidetaka Arita [verfasserIn] Hidenao Ogi [verfasserIn] Akimitsu Hiraki [verfasserIn] Masanori Shinohara [verfasserIn] Hideki Nakayama [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cancer Medicine - Wiley, 2012, 6(2017), 4, Seite 730-738 |
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| Übergeordnetes Werk: |
volume:6 ; year:2017 ; number:4 ; pages:730-738 |
| Links: |
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| DOI / URN: |
10.1002/cam4.1005 |
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| Katalog-ID: |
DOAJ033502528 |
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| 245 | 1 | 0 | |a Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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| 520 | |a Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. | ||
| 650 | 4 | |a Lymphocyte infiltration | |
| 650 | 4 | |a malignant transformation | |
| 650 | 4 | |a oral leukoplakia | |
| 650 | 4 | |a oral squamous cell carcinoma | |
| 650 | 4 | |a SMAD4 | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Ryoji Yoshida |e verfasserin |4 aut | |
| 700 | 0 | |a Yuichiro Matsuoka |e verfasserin |4 aut | |
| 700 | 0 | |a Masashi Nagata |e verfasserin |4 aut | |
| 700 | 0 | |a Akiyuki Hirosue |e verfasserin |4 aut | |
| 700 | 0 | |a Kenta Kawahara |e verfasserin |4 aut | |
| 700 | 0 | |a Takuya Nakamura |e verfasserin |4 aut | |
| 700 | 0 | |a Masafumi Nakamoto |e verfasserin |4 aut | |
| 700 | 0 | |a Masatoshi Hirayama |e verfasserin |4 aut | |
| 700 | 0 | |a Nozomu Takahashi |e verfasserin |4 aut | |
| 700 | 0 | |a Hikaru Nakashima |e verfasserin |4 aut | |
| 700 | 0 | |a Hidetaka Arita |e verfasserin |4 aut | |
| 700 | 0 | |a Hidenao Ogi |e verfasserin |4 aut | |
| 700 | 0 | |a Akimitsu Hiraki |e verfasserin |4 aut | |
| 700 | 0 | |a Masanori Shinohara |e verfasserin |4 aut | |
| 700 | 0 | |a Hideki Nakayama |e verfasserin |4 aut | |
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10.1002/cam4.1005 doi (DE-627)DOAJ033502528 (DE-599)DOAJae84eb7dd6ba4c0c9d435baab5344692 DE-627 ger DE-627 rakwb eng RC254-282 Junki Sakata verfasserin aut Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ryoji Yoshida verfasserin aut Yuichiro Matsuoka verfasserin aut Masashi Nagata verfasserin aut Akiyuki Hirosue verfasserin aut Kenta Kawahara verfasserin aut Takuya Nakamura verfasserin aut Masafumi Nakamoto verfasserin aut Masatoshi Hirayama verfasserin aut Nozomu Takahashi verfasserin aut Hikaru Nakashima verfasserin aut Hidetaka Arita verfasserin aut Hidenao Ogi verfasserin aut Akimitsu Hiraki verfasserin aut Masanori Shinohara verfasserin aut Hideki Nakayama verfasserin aut In Cancer Medicine Wiley, 2012 6(2017), 4, Seite 730-738 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:6 year:2017 number:4 pages:730-738 https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 kostenfrei https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 4 730-738 |
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10.1002/cam4.1005 doi (DE-627)DOAJ033502528 (DE-599)DOAJae84eb7dd6ba4c0c9d435baab5344692 DE-627 ger DE-627 rakwb eng RC254-282 Junki Sakata verfasserin aut Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ryoji Yoshida verfasserin aut Yuichiro Matsuoka verfasserin aut Masashi Nagata verfasserin aut Akiyuki Hirosue verfasserin aut Kenta Kawahara verfasserin aut Takuya Nakamura verfasserin aut Masafumi Nakamoto verfasserin aut Masatoshi Hirayama verfasserin aut Nozomu Takahashi verfasserin aut Hikaru Nakashima verfasserin aut Hidetaka Arita verfasserin aut Hidenao Ogi verfasserin aut Akimitsu Hiraki verfasserin aut Masanori Shinohara verfasserin aut Hideki Nakayama verfasserin aut In Cancer Medicine Wiley, 2012 6(2017), 4, Seite 730-738 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:6 year:2017 number:4 pages:730-738 https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 kostenfrei https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 4 730-738 |
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10.1002/cam4.1005 doi (DE-627)DOAJ033502528 (DE-599)DOAJae84eb7dd6ba4c0c9d435baab5344692 DE-627 ger DE-627 rakwb eng RC254-282 Junki Sakata verfasserin aut Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ryoji Yoshida verfasserin aut Yuichiro Matsuoka verfasserin aut Masashi Nagata verfasserin aut Akiyuki Hirosue verfasserin aut Kenta Kawahara verfasserin aut Takuya Nakamura verfasserin aut Masafumi Nakamoto verfasserin aut Masatoshi Hirayama verfasserin aut Nozomu Takahashi verfasserin aut Hikaru Nakashima verfasserin aut Hidetaka Arita verfasserin aut Hidenao Ogi verfasserin aut Akimitsu Hiraki verfasserin aut Masanori Shinohara verfasserin aut Hideki Nakayama verfasserin aut In Cancer Medicine Wiley, 2012 6(2017), 4, Seite 730-738 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:6 year:2017 number:4 pages:730-738 https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 kostenfrei https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 4 730-738 |
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10.1002/cam4.1005 doi (DE-627)DOAJ033502528 (DE-599)DOAJae84eb7dd6ba4c0c9d435baab5344692 DE-627 ger DE-627 rakwb eng RC254-282 Junki Sakata verfasserin aut Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ryoji Yoshida verfasserin aut Yuichiro Matsuoka verfasserin aut Masashi Nagata verfasserin aut Akiyuki Hirosue verfasserin aut Kenta Kawahara verfasserin aut Takuya Nakamura verfasserin aut Masafumi Nakamoto verfasserin aut Masatoshi Hirayama verfasserin aut Nozomu Takahashi verfasserin aut Hikaru Nakashima verfasserin aut Hidetaka Arita verfasserin aut Hidenao Ogi verfasserin aut Akimitsu Hiraki verfasserin aut Masanori Shinohara verfasserin aut Hideki Nakayama verfasserin aut In Cancer Medicine Wiley, 2012 6(2017), 4, Seite 730-738 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:6 year:2017 number:4 pages:730-738 https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 kostenfrei https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 4 730-738 |
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10.1002/cam4.1005 doi (DE-627)DOAJ033502528 (DE-599)DOAJae84eb7dd6ba4c0c9d435baab5344692 DE-627 ger DE-627 rakwb eng RC254-282 Junki Sakata verfasserin aut Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ryoji Yoshida verfasserin aut Yuichiro Matsuoka verfasserin aut Masashi Nagata verfasserin aut Akiyuki Hirosue verfasserin aut Kenta Kawahara verfasserin aut Takuya Nakamura verfasserin aut Masafumi Nakamoto verfasserin aut Masatoshi Hirayama verfasserin aut Nozomu Takahashi verfasserin aut Hikaru Nakashima verfasserin aut Hidetaka Arita verfasserin aut Hidenao Ogi verfasserin aut Akimitsu Hiraki verfasserin aut Masanori Shinohara verfasserin aut Hideki Nakayama verfasserin aut In Cancer Medicine Wiley, 2012 6(2017), 4, Seite 730-738 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:6 year:2017 number:4 pages:730-738 https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 kostenfrei https://doi.org/10.1002/cam4.1005 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2017 4 730-738 |
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Junki Sakata @@aut@@ Ryoji Yoshida @@aut@@ Yuichiro Matsuoka @@aut@@ Masashi Nagata @@aut@@ Akiyuki Hirosue @@aut@@ Kenta Kawahara @@aut@@ Takuya Nakamura @@aut@@ Masafumi Nakamoto @@aut@@ Masatoshi Hirayama @@aut@@ Nozomu Takahashi @@aut@@ Hikaru Nakashima @@aut@@ Hidetaka Arita @@aut@@ Hidenao Ogi @@aut@@ Akimitsu Hiraki @@aut@@ Masanori Shinohara @@aut@@ Hideki Nakayama @@aut@@ |
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SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). 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Junki Sakata |
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Junki Sakata misc RC254-282 misc Lymphocyte infiltration misc malignant transformation misc oral leukoplakia misc oral squamous cell carcinoma misc SMAD4 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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RC254-282 Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia Lymphocyte infiltration malignant transformation oral leukoplakia oral squamous cell carcinoma SMAD4 |
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misc RC254-282 misc Lymphocyte infiltration misc malignant transformation misc oral leukoplakia misc oral squamous cell carcinoma misc SMAD4 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RC254-282 misc Lymphocyte infiltration misc malignant transformation misc oral leukoplakia misc oral squamous cell carcinoma misc SMAD4 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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misc RC254-282 misc Lymphocyte infiltration misc malignant transformation misc oral leukoplakia misc oral squamous cell carcinoma misc SMAD4 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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Junki Sakata Ryoji Yoshida Yuichiro Matsuoka Masashi Nagata Akiyuki Hirosue Kenta Kawahara Takuya Nakamura Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Hikaru Nakashima Hidetaka Arita Hidenao Ogi Akimitsu Hiraki Masanori Shinohara Hideki Nakayama |
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predictive value of the combination of smad4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
| abstract |
Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. |
| abstractGer |
Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. |
| abstract_unstemmed |
Abstract Oral leukoplakia (OL) is a common, potentially malignant disorder of the oral cavity. SMAD4 was initially identified as a tumor suppressor and central mediator of transforming growth factor (TGF)‐β signaling. In this study, we aimed to determine the expression patterns of SMAD4 in OL, its relationship with the degree of inflammation, and its clinical implications as a biomarker for OL malignant transformation. A total of 150 patients with OL were enrolled in this study. Paraffin‐embedded sections obtained from biopsy or resection specimens were subjected to immunohistochemical analysis. Associations among the status of epithelial SMAD4 expression, stromal lymphocyte infiltration, and malignant transformation of OL were examined. Malignant transformation was significantly associated with the status of SMAD4 expression (P = 0.0017) and lymphocyte infiltration status (P = 0.0054). Cox regression analysis, based on the event‐free survival (EFS), revealed that a low SMAD4 expression was a significant prognostic factor in OL patients (hazard ratio, 2.632; P = 0.043). In addition, a low SMAD4 expression was closely correlated with high lymphocyte infiltration (P = 0.00035), resulting in a significant correlation between the combination of low SMAD4 expression and high lymphocyte infiltration with malignant transformation of OL (P = 0.00027). The combination of the status of epithelial SMAD4 expression and stromal lymphocyte infiltration may be a useful biomarker for predicting malignant transformation in OL patients. These results suggest that not only epithelial SMAD4 loss, but also stromal features, may regulate the risk of malignant transformation of OL. |
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Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia |
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https://doi.org/10.1002/cam4.1005 https://doaj.org/article/ae84eb7dd6ba4c0c9d435baab5344692 https://doaj.org/toc/2045-7634 |
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Ryoji Yoshida Yuichiro Matsuoka Masashi Nagata Akiyuki Hirosue Kenta Kawahara Takuya Nakamura Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Hikaru Nakashima Hidetaka Arita Hidenao Ogi Akimitsu Hiraki Masanori Shinohara Hideki Nakayama |
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Ryoji Yoshida Yuichiro Matsuoka Masashi Nagata Akiyuki Hirosue Kenta Kawahara Takuya Nakamura Masafumi Nakamoto Masatoshi Hirayama Nozomu Takahashi Hikaru Nakashima Hidetaka Arita Hidenao Ogi Akimitsu Hiraki Masanori Shinohara Hideki Nakayama |
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