The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients
Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Cen...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dorobisz K [verfasserIn] Wlodarska-Polinska I [verfasserIn] Pazdro-Zastawny K [verfasserIn] Rutkowski T [verfasserIn] Palka P [verfasserIn] Dworzecki T [verfasserIn] Zatonski T [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cancer Management and Research - Dove Medical Press, 2009, (2019), Seite 6603-6614 |
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| Übergeordnetes Werk: |
year:2019 ; pages:6603-6614 |
| Links: |
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DOAJ033550050 |
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| 245 | 1 | 4 | |a The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients |
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| 520 | |a Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer | ||
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(DE-627)DOAJ033550050 (DE-599)DOAJb42fbb0301a7410fae1e8a31a045e9aa DE-627 ger DE-627 rakwb eng RC254-282 Dorobisz K verfasserin aut The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer carcinoma of unknown primary site squamous cell carcinoma head and neck surgery head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wlodarska-Polinska I verfasserin aut Pazdro-Zastawny K verfasserin aut Rutkowski T verfasserin aut Palka P verfasserin aut Dworzecki T verfasserin aut Zatonski T verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2019), Seite 6603-6614 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2019 pages:6603-6614 https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa kostenfrei https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6603-6614 |
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(DE-627)DOAJ033550050 (DE-599)DOAJb42fbb0301a7410fae1e8a31a045e9aa DE-627 ger DE-627 rakwb eng RC254-282 Dorobisz K verfasserin aut The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer carcinoma of unknown primary site squamous cell carcinoma head and neck surgery head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wlodarska-Polinska I verfasserin aut Pazdro-Zastawny K verfasserin aut Rutkowski T verfasserin aut Palka P verfasserin aut Dworzecki T verfasserin aut Zatonski T verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2019), Seite 6603-6614 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2019 pages:6603-6614 https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa kostenfrei https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6603-6614 |
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(DE-627)DOAJ033550050 (DE-599)DOAJb42fbb0301a7410fae1e8a31a045e9aa DE-627 ger DE-627 rakwb eng RC254-282 Dorobisz K verfasserin aut The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer carcinoma of unknown primary site squamous cell carcinoma head and neck surgery head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wlodarska-Polinska I verfasserin aut Pazdro-Zastawny K verfasserin aut Rutkowski T verfasserin aut Palka P verfasserin aut Dworzecki T verfasserin aut Zatonski T verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2019), Seite 6603-6614 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2019 pages:6603-6614 https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa kostenfrei https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6603-6614 |
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(DE-627)DOAJ033550050 (DE-599)DOAJb42fbb0301a7410fae1e8a31a045e9aa DE-627 ger DE-627 rakwb eng RC254-282 Dorobisz K verfasserin aut The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer carcinoma of unknown primary site squamous cell carcinoma head and neck surgery head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wlodarska-Polinska I verfasserin aut Pazdro-Zastawny K verfasserin aut Rutkowski T verfasserin aut Palka P verfasserin aut Dworzecki T verfasserin aut Zatonski T verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2019), Seite 6603-6614 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2019 pages:6603-6614 https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa kostenfrei https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6603-6614 |
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(DE-627)DOAJ033550050 (DE-599)DOAJb42fbb0301a7410fae1e8a31a045e9aa DE-627 ger DE-627 rakwb eng RC254-282 Dorobisz K verfasserin aut The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer carcinoma of unknown primary site squamous cell carcinoma head and neck surgery head and neck cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Wlodarska-Polinska I verfasserin aut Pazdro-Zastawny K verfasserin aut Rutkowski T verfasserin aut Palka P verfasserin aut Dworzecki T verfasserin aut Zatonski T verfasserin aut In Cancer Management and Research Dove Medical Press, 2009 (2019), Seite 6603-6614 (DE-627)606030840 (DE-600)2508013-1 11791322 nnns year:2019 pages:6603-6614 https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa kostenfrei https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR kostenfrei https://doaj.org/toc/1179-1322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2019 6603-6614 |
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The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients |
| abstract |
Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer |
| abstractGer |
Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer |
| abstract_unstemmed |
Karolina Dorobisz,1 Iwona Wlodarska-Polinska,2 Katarzyna Pazdro-Zastawny,1 Tomasz Rutkowski,3 Piotr Palka,3 Tomasz Dworzecki,2 Tomasz Zatonski11Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland; 2Department of Radiotherapy, Oncotherapy International Center, Walbrzych, Poland; 3Department of Radiation and Clinical Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, PolandIntroduction: Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. According to statistics, a primary site is usually located in the oropharynx.Study objective: The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites in patients treated in the region of Lower Silesia and Silesia. The aim of the study was to show a retrospective analysis of 233 CUP patients to assess how clinical features, diagnosis and treatment affect the survival of patients.Material and methods: The diagnostics of patients included panendoscopy with specimen collection (nasoendoscopy, laryngoscopy, esophagoscopy, brochoscopy), computed tomography examination of the neck, chest, abdomen and pelvis minor, as well as positron emission tomography examination. Tonsilletomy was performed in 37 patients. Neck dissection was carried out in 109 subjects and 165 patients were treated bt radiotherapy, and 135 by chemotherapy.Conclusions: Tonsillectomy is required in CUP patients with the negative results of biopsy and imaging tests. It gives a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients.Combination therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients. The general condition of patient and younger age have an impact on prognosis and survival.Keywords: carcinoma of unknown primary site, squamous cell carcinoma, head and neck surgery, head and neck cancer |
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The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients |
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https://doaj.org/article/b42fbb0301a7410fae1e8a31a045e9aa https://www.dovepress.com/the-impact-of-the-patientrsquos-condition-diagnostic-procedures-and-tr-peer-reviewed-article-CMAR https://doaj.org/toc/1179-1322 |
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