Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine

Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Krzysztof Chmielowiec [verfasserIn] Jolanta Chmielowiec [verfasserIn] Aleksandra Strońska-Pluta [verfasserIn] Grzegorz Trybek [verfasserIn] Małgorzata Śmiarowska [verfasserIn] Aleksandra Suchanecka [verfasserIn] Grzegorz Woźniak [verfasserIn] Aleksandra Jaroń [verfasserIn] Anna Grzywacz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	gene rs16969968 rs578776 rs1051730

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 19(2022), 10478, p 10478
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:10478, p 10478

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph191710478

Katalog-ID:	DOAJ033551316

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allfields	10.3390/ijerph191710478 doi (DE-627)DOAJ033551316 (DE-599)DOAJ3af7461f7d69453dbd932ec11f92c3e7 DE-627 ger DE-627 rakwb eng Krzysztof Chmielowiec verfasserin aut Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R Jolanta Chmielowiec verfasserin aut Aleksandra Strońska-Pluta verfasserin aut Grzegorz Trybek verfasserin aut Małgorzata Śmiarowska verfasserin aut Aleksandra Suchanecka verfasserin aut Grzegorz Woźniak verfasserin aut Aleksandra Jaroń verfasserin aut Anna Grzywacz verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10478, p 10478 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10478, p 10478 https://doi.org/10.3390/ijerph191710478 kostenfrei https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 kostenfrei https://www.mdpi.com/1660-4601/19/17/10478 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10478, p 10478
spelling	10.3390/ijerph191710478 doi (DE-627)DOAJ033551316 (DE-599)DOAJ3af7461f7d69453dbd932ec11f92c3e7 DE-627 ger DE-627 rakwb eng Krzysztof Chmielowiec verfasserin aut Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R Jolanta Chmielowiec verfasserin aut Aleksandra Strońska-Pluta verfasserin aut Grzegorz Trybek verfasserin aut Małgorzata Śmiarowska verfasserin aut Aleksandra Suchanecka verfasserin aut Grzegorz Woźniak verfasserin aut Aleksandra Jaroń verfasserin aut Anna Grzywacz verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10478, p 10478 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10478, p 10478 https://doi.org/10.3390/ijerph191710478 kostenfrei https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 kostenfrei https://www.mdpi.com/1660-4601/19/17/10478 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10478, p 10478
allfields_unstemmed	10.3390/ijerph191710478 doi (DE-627)DOAJ033551316 (DE-599)DOAJ3af7461f7d69453dbd932ec11f92c3e7 DE-627 ger DE-627 rakwb eng Krzysztof Chmielowiec verfasserin aut Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R Jolanta Chmielowiec verfasserin aut Aleksandra Strońska-Pluta verfasserin aut Grzegorz Trybek verfasserin aut Małgorzata Śmiarowska verfasserin aut Aleksandra Suchanecka verfasserin aut Grzegorz Woźniak verfasserin aut Aleksandra Jaroń verfasserin aut Anna Grzywacz verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10478, p 10478 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10478, p 10478 https://doi.org/10.3390/ijerph191710478 kostenfrei https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 kostenfrei https://www.mdpi.com/1660-4601/19/17/10478 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10478, p 10478
allfieldsGer	10.3390/ijerph191710478 doi (DE-627)DOAJ033551316 (DE-599)DOAJ3af7461f7d69453dbd932ec11f92c3e7 DE-627 ger DE-627 rakwb eng Krzysztof Chmielowiec verfasserin aut Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R Jolanta Chmielowiec verfasserin aut Aleksandra Strońska-Pluta verfasserin aut Grzegorz Trybek verfasserin aut Małgorzata Śmiarowska verfasserin aut Aleksandra Suchanecka verfasserin aut Grzegorz Woźniak verfasserin aut Aleksandra Jaroń verfasserin aut Anna Grzywacz verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10478, p 10478 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10478, p 10478 https://doi.org/10.3390/ijerph191710478 kostenfrei https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 kostenfrei https://www.mdpi.com/1660-4601/19/17/10478 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10478, p 10478
allfieldsSound	10.3390/ijerph191710478 doi (DE-627)DOAJ033551316 (DE-599)DOAJ3af7461f7d69453dbd932ec11f92c3e7 DE-627 ger DE-627 rakwb eng Krzysztof Chmielowiec verfasserin aut Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction. gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R Jolanta Chmielowiec verfasserin aut Aleksandra Strońska-Pluta verfasserin aut Grzegorz Trybek verfasserin aut Małgorzata Śmiarowska verfasserin aut Aleksandra Suchanecka verfasserin aut Grzegorz Woźniak verfasserin aut Aleksandra Jaroń verfasserin aut Anna Grzywacz verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10478, p 10478 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10478, p 10478 https://doi.org/10.3390/ijerph191710478 kostenfrei https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 kostenfrei https://www.mdpi.com/1660-4601/19/17/10478 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10478, p 10478
language	English
source	In International Journal of Environmental Research and Public Health 19(2022), 10478, p 10478 volume:19 year:2022 number:10478, p 10478
sourceStr	In International Journal of Environmental Research and Public Health 19(2022), 10478, p 10478 volume:19 year:2022 number:10478, p 10478
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730 Medicine R
isfreeaccess_bool	true
container_title	International Journal of Environmental Research and Public Health
authorswithroles_txt_mv	Krzysztof Chmielowiec @@aut@@ Jolanta Chmielowiec @@aut@@ Aleksandra Strońska-Pluta @@aut@@ Grzegorz Trybek @@aut@@ Małgorzata Śmiarowska @@aut@@ Aleksandra Suchanecka @@aut@@ Grzegorz Woźniak @@aut@@ Aleksandra Jaroń @@aut@@ Anna Grzywacz @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	477992463
id	DOAJ033551316
language_de	englisch
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author	Krzysztof Chmielowiec
spellingShingle	Krzysztof Chmielowiec misc gene misc <i<CHRNA5</i< misc <i<CHRNA3</i< misc rs16969968 misc rs578776 misc rs1051730 misc Medicine misc R Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine
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topic_title	Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine gene <i<CHRNA5</i< <i<CHRNA3</i< rs16969968 rs578776 rs1051730
topic	misc gene misc <i<CHRNA5</i< misc <i<CHRNA3</i< misc rs16969968 misc rs578776 misc rs1051730 misc Medicine misc R
topic_unstemmed	misc gene misc <i<CHRNA5</i< misc <i<CHRNA3</i< misc rs16969968 misc rs578776 misc rs1051730 misc Medicine misc R
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title	Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine
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title_full	Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine
author_sort	Krzysztof Chmielowiec
journal	International Journal of Environmental Research and Public Health
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author_browse	Krzysztof Chmielowiec Jolanta Chmielowiec Aleksandra Strońska-Pluta Grzegorz Trybek Małgorzata Śmiarowska Aleksandra Suchanecka Grzegorz Woźniak Aleksandra Jaroń Anna Grzywacz
container_volume	19
format_se	Elektronische Aufsätze
author-letter	Krzysztof Chmielowiec
doi_str_mv	10.3390/ijerph191710478
author2-role	verfasserin
title_sort	association of polymorphism <i<chrna5</i< and <i<chrna3</i< gene in people addicted to nicotine
title_auth	Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine
abstract	Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction.
abstractGer	Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction.
abstract_unstemmed	Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, the variants in the <i<CHRNA5/A3/B4</i< gene cluster on chromosome 15 that encode the α5, α3, and β4 subunits have recently received a lot of attention. Importantly, variants in this gene cluster have been associated with nicotine addiction. Among the many significant variants in this cluster, the polymorphism SNP rs16969968 seems to be the most interesting factor in nicotine addiction. This polymorphism causes an amino acid change from aspartate to asparagine at position 398 of the α5 nicotinic receptor protein sequence. Our study aimed to analyze three polymorphic variants: the rs16969968 located in the <i<CHRNA5</i< gene, the rs578776 and rs1051730 located in the <i<CHRNA3</i< gene in nicotine-addicted subjects, and in controls. Our study encompasses an association analysis of genotypes and haplotypes. A group of 401 volunteers was recruited for the study and divided into two groups: the study group consisted of addicted smokers and a control group of 200 unrelated non-smokers who were not dependent on any substance and healthy. A statistically significant difference was observed in the frequency of genotypes of the rs1051730 polymorphism of the <i<CHRNA3</i< gene (χ<sup<2</sup< = 6.704 <i<p</i< = 0.035). The T/T genotype was statistically significantly more frequent in the group of nicotine-dependent subjects. The haplotypes rs16969968, rs578776, and rs1051730 were distinguished, of which the G-T-T and G-C-T haplotypes were present only in the study group. With differences in frequencies, statistical significance was noted—for the G-T-T haplotype <i<p</i< = 0.01284 and the G-C-T haplotype <i<p</i< = 0.00775. The research stated that novel haplotypes G-T-T and G-C-T, though with very low-frequency variants in <i<CHRNA3</i<, were associated with nicotine addiction.
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title_short	Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine
url	https://doi.org/10.3390/ijerph191710478 https://doaj.org/article/3af7461f7d69453dbd932ec11f92c3e7 https://www.mdpi.com/1660-4601/19/17/10478 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601
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author2	Jolanta Chmielowiec Aleksandra Strońska-Pluta Grzegorz Trybek Małgorzata Śmiarowska Aleksandra Suchanecka Grzegorz Woźniak Aleksandra Jaroń Anna Grzywacz
author2Str	Jolanta Chmielowiec Aleksandra Strońska-Pluta Grzegorz Trybek Małgorzata Śmiarowska Aleksandra Suchanecka Grzegorz Woźniak Aleksandra Jaroń Anna Grzywacz
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up_date	2024-07-03T18:24:32.928Z
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Association of Polymorphism <i<CHRNA5</i< and <i<CHRNA3</i< Gene in People Addicted to Nicotine

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