High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms

Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Francesca Natale [verfasserIn] Matteo Spinelli [verfasserIn] Saviana Antonella Barbati [verfasserIn] Lucia Leone [verfasserIn] Salvatore Fusco [verfasserIn] Claudio Grassi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 11(2022), 17, p 2661
Übergeordnetes Werk:	volume:11 ; year:2022 ; number:17, p 2661

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells11172661

Katalog-ID:	DOAJ033560269

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topic_facet	hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology
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authorswithroles_txt_mv	Francesca Natale @@aut@@ Matteo Spinelli @@aut@@ Saviana Antonella Barbati @@aut@@ Lucia Leone @@aut@@ Salvatore Fusco @@aut@@ Claudio Grassi @@aut@@
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callnumber-first	Q - Science
author	Francesca Natale
spellingShingle	Francesca Natale misc QH573-671 misc hippocampal adult neurogenesis misc neural stem and progenitor cells misc epigenetics misc maternal HFD misc Cytology High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
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topic_title	QH573-671 High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD
topic	misc QH573-671 misc hippocampal adult neurogenesis misc neural stem and progenitor cells misc epigenetics misc maternal HFD misc Cytology
topic_unstemmed	misc QH573-671 misc hippocampal adult neurogenesis misc neural stem and progenitor cells misc epigenetics misc maternal HFD misc Cytology
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title	High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
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title_full	High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
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author_browse	Francesca Natale Matteo Spinelli Saviana Antonella Barbati Lucia Leone Salvatore Fusco Claudio Grassi
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title_sort	high fat diet multigenerationally affects hippocampal neural stem cell proliferation via epigenetic mechanisms
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title_auth	High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
abstract	Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs.
abstractGer	Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs.
abstract_unstemmed	Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs.
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title_short	High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
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up_date	2024-07-03T18:27:26.049Z
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High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms

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