High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms
Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated...
Ausführliche Beschreibung
Autor*in: |
Francesca Natale [verfasserIn] Matteo Spinelli [verfasserIn] Saviana Antonella Barbati [verfasserIn] Lucia Leone [verfasserIn] Salvatore Fusco [verfasserIn] Claudio Grassi [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
hippocampal adult neurogenesis |
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Übergeordnetes Werk: |
In: Cells - MDPI AG, 2012, 11(2022), 17, p 2661 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:17, p 2661 |
Links: |
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DOI / URN: |
10.3390/cells11172661 |
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Katalog-ID: |
DOAJ033560269 |
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10.3390/cells11172661 doi (DE-627)DOAJ033560269 (DE-599)DOAJf2f0dd8721ae4a209411ae6d01f0d50c DE-627 ger DE-627 rakwb eng QH573-671 Francesca Natale verfasserin aut High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology Matteo Spinelli verfasserin aut Saviana Antonella Barbati verfasserin aut Lucia Leone verfasserin aut Salvatore Fusco verfasserin aut Claudio Grassi verfasserin aut In Cells MDPI AG, 2012 11(2022), 17, p 2661 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:17, p 2661 https://doi.org/10.3390/cells11172661 kostenfrei https://doaj.org/article/f2f0dd8721ae4a209411ae6d01f0d50c kostenfrei https://www.mdpi.com/2073-4409/11/17/2661 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 2661 |
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10.3390/cells11172661 doi (DE-627)DOAJ033560269 (DE-599)DOAJf2f0dd8721ae4a209411ae6d01f0d50c DE-627 ger DE-627 rakwb eng QH573-671 Francesca Natale verfasserin aut High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology Matteo Spinelli verfasserin aut Saviana Antonella Barbati verfasserin aut Lucia Leone verfasserin aut Salvatore Fusco verfasserin aut Claudio Grassi verfasserin aut In Cells MDPI AG, 2012 11(2022), 17, p 2661 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:17, p 2661 https://doi.org/10.3390/cells11172661 kostenfrei https://doaj.org/article/f2f0dd8721ae4a209411ae6d01f0d50c kostenfrei https://www.mdpi.com/2073-4409/11/17/2661 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 2661 |
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10.3390/cells11172661 doi (DE-627)DOAJ033560269 (DE-599)DOAJf2f0dd8721ae4a209411ae6d01f0d50c DE-627 ger DE-627 rakwb eng QH573-671 Francesca Natale verfasserin aut High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology Matteo Spinelli verfasserin aut Saviana Antonella Barbati verfasserin aut Lucia Leone verfasserin aut Salvatore Fusco verfasserin aut Claudio Grassi verfasserin aut In Cells MDPI AG, 2012 11(2022), 17, p 2661 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:17, p 2661 https://doi.org/10.3390/cells11172661 kostenfrei https://doaj.org/article/f2f0dd8721ae4a209411ae6d01f0d50c kostenfrei https://www.mdpi.com/2073-4409/11/17/2661 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 2661 |
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10.3390/cells11172661 doi (DE-627)DOAJ033560269 (DE-599)DOAJf2f0dd8721ae4a209411ae6d01f0d50c DE-627 ger DE-627 rakwb eng QH573-671 Francesca Natale verfasserin aut High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology Matteo Spinelli verfasserin aut Saviana Antonella Barbati verfasserin aut Lucia Leone verfasserin aut Salvatore Fusco verfasserin aut Claudio Grassi verfasserin aut In Cells MDPI AG, 2012 11(2022), 17, p 2661 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:17, p 2661 https://doi.org/10.3390/cells11172661 kostenfrei https://doaj.org/article/f2f0dd8721ae4a209411ae6d01f0d50c kostenfrei https://www.mdpi.com/2073-4409/11/17/2661 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 2661 |
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10.3390/cells11172661 doi (DE-627)DOAJ033560269 (DE-599)DOAJf2f0dd8721ae4a209411ae6d01f0d50c DE-627 ger DE-627 rakwb eng QH573-671 Francesca Natale verfasserin aut High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. hippocampal adult neurogenesis neural stem and progenitor cells epigenetics maternal HFD Cytology Matteo Spinelli verfasserin aut Saviana Antonella Barbati verfasserin aut Lucia Leone verfasserin aut Salvatore Fusco verfasserin aut Claudio Grassi verfasserin aut In Cells MDPI AG, 2012 11(2022), 17, p 2661 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:11 year:2022 number:17, p 2661 https://doi.org/10.3390/cells11172661 kostenfrei https://doaj.org/article/f2f0dd8721ae4a209411ae6d01f0d50c kostenfrei https://www.mdpi.com/2073-4409/11/17/2661 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 17, p 2661 |
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High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms |
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Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. |
abstractGer |
Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. |
abstract_unstemmed |
Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor’s diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2<sub<HFD</sub< and F3<sub<HFD</sub<). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2<sub<HFD</sub< and F3<sub<HFD</sub< mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating stem cell proliferation and neurodifferentiation (i.e., Hes1, NeuroD1, Bdnf). Finally, ancestor HFD-related hyper-activation of both STAT3 and STAT5 induced enhancement of their binding on the regulatory sequences of Gfap gene and an epigenetic switch from permissive to repressive chromatin on the promoter of the NeuroD1 gene. Collectively, our data indicate that maternal HFD multigenerationally affects hippocampal adult neurogenesis via an epigenetic derangement of pro-neurogenic gene expression in NSPCs. |
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7.400016 |