Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer

Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Marco Vella [verfasserIn] Daniela Coniglio [verfasserIn] Alberto Abrate [verfasserIn] Cristina Scalici Gesolfo [verfasserIn] Elena Lo Presti [verfasserIn] Serena Meraviglia [verfasserIn] Vincenzo Serretta [verfasserIn] Alchiede Simonato [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets

Übergeordnetes Werk:	In: Investigative and Clinical Urology - Korean Urological Association, 2017, 60(2019), 2, Seite 91-98
Übergeordnetes Werk:	volume:60 ; year:2019 ; number:2 ; pages:91-98

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4111/icu.2019.60.2.91

Katalog-ID:	DOAJ033568626

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allfields	10.4111/icu.2019.60.2.91 doi (DE-627)DOAJ033568626 (DE-599)DOAJ088415124ee04373a6fe9962db11567a DE-627 ger DE-627 rakwb eng RC870-923 Marco Vella verfasserin aut Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa. Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets Diseases of the genitourinary system. Urology Daniela Coniglio verfasserin aut Alberto Abrate verfasserin aut Cristina Scalici Gesolfo verfasserin aut Elena Lo Presti verfasserin aut Serena Meraviglia verfasserin aut Vincenzo Serretta verfasserin aut Alchiede Simonato verfasserin aut In Investigative and Clinical Urology Korean Urological Association, 2017 60(2019), 2, Seite 91-98 (DE-627)1015717306 2466054X nnns volume:60 year:2019 number:2 pages:91-98 https://doi.org/10.4111/icu.2019.60.2.91 kostenfrei https://doaj.org/article/088415124ee04373a6fe9962db11567a kostenfrei https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-91.pdf kostenfrei https://doaj.org/toc/2466-0493 Journal toc kostenfrei https://doaj.org/toc/2466-054X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2019 2 91-98
spelling	10.4111/icu.2019.60.2.91 doi (DE-627)DOAJ033568626 (DE-599)DOAJ088415124ee04373a6fe9962db11567a DE-627 ger DE-627 rakwb eng RC870-923 Marco Vella verfasserin aut Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa. Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets Diseases of the genitourinary system. Urology Daniela Coniglio verfasserin aut Alberto Abrate verfasserin aut Cristina Scalici Gesolfo verfasserin aut Elena Lo Presti verfasserin aut Serena Meraviglia verfasserin aut Vincenzo Serretta verfasserin aut Alchiede Simonato verfasserin aut In Investigative and Clinical Urology Korean Urological Association, 2017 60(2019), 2, Seite 91-98 (DE-627)1015717306 2466054X nnns volume:60 year:2019 number:2 pages:91-98 https://doi.org/10.4111/icu.2019.60.2.91 kostenfrei https://doaj.org/article/088415124ee04373a6fe9962db11567a kostenfrei https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-91.pdf kostenfrei https://doaj.org/toc/2466-0493 Journal toc kostenfrei https://doaj.org/toc/2466-054X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2019 2 91-98
allfields_unstemmed	10.4111/icu.2019.60.2.91 doi (DE-627)DOAJ033568626 (DE-599)DOAJ088415124ee04373a6fe9962db11567a DE-627 ger DE-627 rakwb eng RC870-923 Marco Vella verfasserin aut Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa. Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets Diseases of the genitourinary system. Urology Daniela Coniglio verfasserin aut Alberto Abrate verfasserin aut Cristina Scalici Gesolfo verfasserin aut Elena Lo Presti verfasserin aut Serena Meraviglia verfasserin aut Vincenzo Serretta verfasserin aut Alchiede Simonato verfasserin aut In Investigative and Clinical Urology Korean Urological Association, 2017 60(2019), 2, Seite 91-98 (DE-627)1015717306 2466054X nnns volume:60 year:2019 number:2 pages:91-98 https://doi.org/10.4111/icu.2019.60.2.91 kostenfrei https://doaj.org/article/088415124ee04373a6fe9962db11567a kostenfrei https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-91.pdf kostenfrei https://doaj.org/toc/2466-0493 Journal toc kostenfrei https://doaj.org/toc/2466-054X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2019 2 91-98
allfieldsGer	10.4111/icu.2019.60.2.91 doi (DE-627)DOAJ033568626 (DE-599)DOAJ088415124ee04373a6fe9962db11567a DE-627 ger DE-627 rakwb eng RC870-923 Marco Vella verfasserin aut Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa. Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets Diseases of the genitourinary system. Urology Daniela Coniglio verfasserin aut Alberto Abrate verfasserin aut Cristina Scalici Gesolfo verfasserin aut Elena Lo Presti verfasserin aut Serena Meraviglia verfasserin aut Vincenzo Serretta verfasserin aut Alchiede Simonato verfasserin aut In Investigative and Clinical Urology Korean Urological Association, 2017 60(2019), 2, Seite 91-98 (DE-627)1015717306 2466054X nnns volume:60 year:2019 number:2 pages:91-98 https://doi.org/10.4111/icu.2019.60.2.91 kostenfrei https://doaj.org/article/088415124ee04373a6fe9962db11567a kostenfrei https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-91.pdf kostenfrei https://doaj.org/toc/2466-0493 Journal toc kostenfrei https://doaj.org/toc/2466-054X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2019 2 91-98
allfieldsSound	10.4111/icu.2019.60.2.91 doi (DE-627)DOAJ033568626 (DE-599)DOAJ088415124ee04373a6fe9962db11567a DE-627 ger DE-627 rakwb eng RC870-923 Marco Vella verfasserin aut Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa. Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets Diseases of the genitourinary system. Urology Daniela Coniglio verfasserin aut Alberto Abrate verfasserin aut Cristina Scalici Gesolfo verfasserin aut Elena Lo Presti verfasserin aut Serena Meraviglia verfasserin aut Vincenzo Serretta verfasserin aut Alchiede Simonato verfasserin aut In Investigative and Clinical Urology Korean Urological Association, 2017 60(2019), 2, Seite 91-98 (DE-627)1015717306 2466054X nnns volume:60 year:2019 number:2 pages:91-98 https://doi.org/10.4111/icu.2019.60.2.91 kostenfrei https://doaj.org/article/088415124ee04373a6fe9962db11567a kostenfrei https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-60-91.pdf kostenfrei https://doaj.org/toc/2466-0493 Journal toc kostenfrei https://doaj.org/toc/2466-054X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 60 2019 2 91-98
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callnumber-first	R - Medicine
author	Marco Vella
spellingShingle	Marco Vella misc RC870-923 misc Biopsy misc Immunologic surveillance misc Neoplasm grading misc Prostatic neoplasms misc T-Lymphocyte subsets misc Diseases of the genitourinary system. Urology Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
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topic_title	RC870-923 Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer Biopsy Immunologic surveillance Neoplasm grading Prostatic neoplasms T-Lymphocyte subsets
topic	misc RC870-923 misc Biopsy misc Immunologic surveillance misc Neoplasm grading misc Prostatic neoplasms misc T-Lymphocyte subsets misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RC870-923 misc Biopsy misc Immunologic surveillance misc Neoplasm grading misc Prostatic neoplasms misc T-Lymphocyte subsets misc Diseases of the genitourinary system. Urology
topic_browse	misc RC870-923 misc Biopsy misc Immunologic surveillance misc Neoplasm grading misc Prostatic neoplasms misc T-Lymphocyte subsets misc Diseases of the genitourinary system. Urology
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title	Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
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title_full	Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
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author_browse	Marco Vella Daniela Coniglio Alberto Abrate Cristina Scalici Gesolfo Elena Lo Presti Serena Meraviglia Vincenzo Serretta Alchiede Simonato
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title_sort	characterization of human infiltrating and circulating gamma-delta t cells in prostate cancer
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title_auth	Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
abstract	Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.
abstractGer	Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.
abstract_unstemmed	Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy. Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. However a non-significant trend for lower infiltrate in higher ISUP grade cancer tissue was observed, suggesting a possible role for the immunosurveillance of PCa.
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title_short	Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer
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Materials and Methods: A consecutive series of 43 outpatients underwent trans-rectal echo-guided prostate biopsy for suspected PCa. Flow cytometry analysis was used to identify and characterize the γδ T cells populations in peripheral blood and tissue samples. Patients were stratified according to the presence or not of PCa, and its International Society of Urological Pathology (ISUP) grade (1 vs. ≥2). Results: The distribution of γδ T cells in peripheral blood and prostate tissue showed wide variability and non-significant differences. A slightly higher percentage of δ2 T cells and a slightly lower percentage of δ1 T cells were found in peripheral blood of cancer patients. A non-significantly higher percentage of both Vδ1 and Vδ2 was expressed in cancer tissues, but a trend for lower distribution of δ1 and δ2 T cells was observed in ISUP grade ≥2. The “central memory” and “effector memory” were the most expressed T cells phenotype in peripheral blood and tissue samples. However no substantial differences in T cells subtypes distribution between cancer and healthy tissue were observed. Conclusions: No substantially different percentages of γδ T cells were found in peripheral blood and biopsy samples of healthy and PCa patients. 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Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer

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