Multiple Primary Malignancies in Patients with Gynecologic Cancer

Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 202...
Ausführliche Beschreibung

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Autor*in:	Eun-Jung Yang [verfasserIn] Ji-Hyeon Lee [verfasserIn] A-Jin Lee [verfasserIn] Nae-Ry Kim [verfasserIn] Yong-Taek Ouh [verfasserIn] Mi-Kyung Kim [verfasserIn] Seung-Hyuk Shim [verfasserIn] Sun-Joo Lee [verfasserIn] Tae-Jin Kim [verfasserIn] Kyeong-A So [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 11(2021), 1, p 115
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:1, p 115

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm11010115

Katalog-ID:	DOAJ033835659

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520			\|a Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis.
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allfields	10.3390/jcm11010115 doi (DE-627)DOAJ033835659 (DE-599)DOAJd92209af88bf4aae867f5a33f7756883 DE-627 ger DE-627 rakwb eng Eun-Jung Yang verfasserin aut Multiple Primary Malignancies in Patients with Gynecologic Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis. multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies Medicine R Ji-Hyeon Lee verfasserin aut A-Jin Lee verfasserin aut Nae-Ry Kim verfasserin aut Yong-Taek Ouh verfasserin aut Mi-Kyung Kim verfasserin aut Seung-Hyuk Shim verfasserin aut Sun-Joo Lee verfasserin aut Tae-Jin Kim verfasserin aut Kyeong-A So verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2021), 1, p 115 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2021 number:1, p 115 https://doi.org/10.3390/jcm11010115 kostenfrei https://doaj.org/article/d92209af88bf4aae867f5a33f7756883 kostenfrei https://www.mdpi.com/2077-0383/11/1/115 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 115
spelling	10.3390/jcm11010115 doi (DE-627)DOAJ033835659 (DE-599)DOAJd92209af88bf4aae867f5a33f7756883 DE-627 ger DE-627 rakwb eng Eun-Jung Yang verfasserin aut Multiple Primary Malignancies in Patients with Gynecologic Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis. multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies Medicine R Ji-Hyeon Lee verfasserin aut A-Jin Lee verfasserin aut Nae-Ry Kim verfasserin aut Yong-Taek Ouh verfasserin aut Mi-Kyung Kim verfasserin aut Seung-Hyuk Shim verfasserin aut Sun-Joo Lee verfasserin aut Tae-Jin Kim verfasserin aut Kyeong-A So verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2021), 1, p 115 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2021 number:1, p 115 https://doi.org/10.3390/jcm11010115 kostenfrei https://doaj.org/article/d92209af88bf4aae867f5a33f7756883 kostenfrei https://www.mdpi.com/2077-0383/11/1/115 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 115
allfields_unstemmed	10.3390/jcm11010115 doi (DE-627)DOAJ033835659 (DE-599)DOAJd92209af88bf4aae867f5a33f7756883 DE-627 ger DE-627 rakwb eng Eun-Jung Yang verfasserin aut Multiple Primary Malignancies in Patients with Gynecologic Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis. multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies Medicine R Ji-Hyeon Lee verfasserin aut A-Jin Lee verfasserin aut Nae-Ry Kim verfasserin aut Yong-Taek Ouh verfasserin aut Mi-Kyung Kim verfasserin aut Seung-Hyuk Shim verfasserin aut Sun-Joo Lee verfasserin aut Tae-Jin Kim verfasserin aut Kyeong-A So verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2021), 1, p 115 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2021 number:1, p 115 https://doi.org/10.3390/jcm11010115 kostenfrei https://doaj.org/article/d92209af88bf4aae867f5a33f7756883 kostenfrei https://www.mdpi.com/2077-0383/11/1/115 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 115
allfieldsGer	10.3390/jcm11010115 doi (DE-627)DOAJ033835659 (DE-599)DOAJd92209af88bf4aae867f5a33f7756883 DE-627 ger DE-627 rakwb eng Eun-Jung Yang verfasserin aut Multiple Primary Malignancies in Patients with Gynecologic Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis. multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies Medicine R Ji-Hyeon Lee verfasserin aut A-Jin Lee verfasserin aut Nae-Ry Kim verfasserin aut Yong-Taek Ouh verfasserin aut Mi-Kyung Kim verfasserin aut Seung-Hyuk Shim verfasserin aut Sun-Joo Lee verfasserin aut Tae-Jin Kim verfasserin aut Kyeong-A So verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2021), 1, p 115 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2021 number:1, p 115 https://doi.org/10.3390/jcm11010115 kostenfrei https://doaj.org/article/d92209af88bf4aae867f5a33f7756883 kostenfrei https://www.mdpi.com/2077-0383/11/1/115 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 115
allfieldsSound	10.3390/jcm11010115 doi (DE-627)DOAJ033835659 (DE-599)DOAJd92209af88bf4aae867f5a33f7756883 DE-627 ger DE-627 rakwb eng Eun-Jung Yang verfasserin aut Multiple Primary Malignancies in Patients with Gynecologic Cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis. multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies Medicine R Ji-Hyeon Lee verfasserin aut A-Jin Lee verfasserin aut Nae-Ry Kim verfasserin aut Yong-Taek Ouh verfasserin aut Mi-Kyung Kim verfasserin aut Seung-Hyuk Shim verfasserin aut Sun-Joo Lee verfasserin aut Tae-Jin Kim verfasserin aut Kyeong-A So verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 11(2021), 1, p 115 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:11 year:2021 number:1, p 115 https://doi.org/10.3390/jcm11010115 kostenfrei https://doaj.org/article/d92209af88bf4aae867f5a33f7756883 kostenfrei https://www.mdpi.com/2077-0383/11/1/115 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 1, p 115
language	English
source	In Journal of Clinical Medicine 11(2021), 1, p 115 volume:11 year:2021 number:1, p 115
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author	Eun-Jung Yang
spellingShingle	Eun-Jung Yang misc multiple primary malignant tumors misc gynecologic cancers misc synchronous malignancies misc metachronous malignancies misc Medicine misc R Multiple Primary Malignancies in Patients with Gynecologic Cancer
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topic_title	Multiple Primary Malignancies in Patients with Gynecologic Cancer multiple primary malignant tumors gynecologic cancers synchronous malignancies metachronous malignancies
topic	misc multiple primary malignant tumors misc gynecologic cancers misc synchronous malignancies misc metachronous malignancies misc Medicine misc R
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title	Multiple Primary Malignancies in Patients with Gynecologic Cancer
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title_sort	multiple primary malignancies in patients with gynecologic cancer
title_auth	Multiple Primary Malignancies in Patients with Gynecologic Cancer
abstract	Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis.
abstractGer	Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis.
abstract_unstemmed	Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer. Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. A systematic examination after primary cancer diagnosis could facilitate the early diagnosis of secondary primary malignancy, thereby improving patient prognosis.
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Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Results: The prevalence of MPMT with gynecologic cancer in patients was 8.6% and the mean diagnostic period between primary and secondary cancer was 60 months. Furthermore, 20 of the 165 patients with MPMT had multiple primary gynecologic cancers (MPGC), whereas 145 had gynecologic cancer coexisting with non-gynecologic cancer (GNC). Endometrial-ovarian cancer (60%) was the most common coexisting cancer in the MPGC group, whereas the most common non-gynecologic cancer in the GNC group was breast cancer (34.5%). There were 48 patients with synchronous cancer and 117 patients with metachronous cancer. The incidence of synchronous cancer was higher in the MPGC group than in the GNC group (<i<p</i< = 0.037). Significantly more patients had early-stage ovarian cancer in the MPGC group than in the GNC group (<i<p</i< = 0.031). The overall recurrence and mortality rates were 15.8% and 8.5%, respectively, in patients with MPMT. Conclusion: Synchronous cancer incidence was significantly higher in the MPGC than in the GNC group. Early-stage ovarian cancer was more highly diagnosed in patients with MPGC than in those with GNC. 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Multiple Primary Malignancies in Patients with Gynecologic Cancer

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