The importance of cytokines for the atopic dermatitis pathogenesis
The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genet...
Ausführliche Beschreibung
Autor*in: |
E. E. Varlamov [verfasserIn] A. N. Pampura [verfasserIn] V. S. Sukhorukov [verfasserIn] |
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E-Artikel |
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Russisch |
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2018 |
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In: Rossijskij Vestnik Perinatologii i Pediatrii - Ltd. “The National Academy of Pediatric Science and Innovation”, 2018, 63(2018), 1, Seite 28-33 |
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Übergeordnetes Werk: |
volume:63 ; year:2018 ; number:1 ; pages:28-33 |
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Link aufrufen |
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DOI / URN: |
10.21508/1027-4065-2018-63-1-28-33 |
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Katalog-ID: |
DOAJ033874735 |
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10.21508/1027-4065-2018-63-1-28-33 doi (DE-627)DOAJ033874735 (DE-599)DOAJ6c96d094c5964891b8ea8522f8fd240b DE-627 ger DE-627 rakwb rus RJ1-570 E. E. Varlamov verfasserin aut The importance of cytokines for the atopic dermatitis pathogenesis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. дети атопический дерматит патогенез цитокины Pediatrics A. N. Pampura verfasserin aut V. S. Sukhorukov verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 63(2018), 1, Seite 28-33 (DE-627)1043470638 25002228 nnns volume:63 year:2018 number:1 pages:28-33 https://doi.org/10.21508/1027-4065-2018-63-1-28-33 kostenfrei https://doaj.org/article/6c96d094c5964891b8ea8522f8fd240b kostenfrei https://www.ped-perinatology.ru/jour/article/view/615 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 1 28-33 |
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10.21508/1027-4065-2018-63-1-28-33 doi (DE-627)DOAJ033874735 (DE-599)DOAJ6c96d094c5964891b8ea8522f8fd240b DE-627 ger DE-627 rakwb rus RJ1-570 E. E. Varlamov verfasserin aut The importance of cytokines for the atopic dermatitis pathogenesis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. дети атопический дерматит патогенез цитокины Pediatrics A. N. Pampura verfasserin aut V. S. Sukhorukov verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 63(2018), 1, Seite 28-33 (DE-627)1043470638 25002228 nnns volume:63 year:2018 number:1 pages:28-33 https://doi.org/10.21508/1027-4065-2018-63-1-28-33 kostenfrei https://doaj.org/article/6c96d094c5964891b8ea8522f8fd240b kostenfrei https://www.ped-perinatology.ru/jour/article/view/615 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 1 28-33 |
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10.21508/1027-4065-2018-63-1-28-33 doi (DE-627)DOAJ033874735 (DE-599)DOAJ6c96d094c5964891b8ea8522f8fd240b DE-627 ger DE-627 rakwb rus RJ1-570 E. E. Varlamov verfasserin aut The importance of cytokines for the atopic dermatitis pathogenesis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. дети атопический дерматит патогенез цитокины Pediatrics A. N. Pampura verfasserin aut V. S. Sukhorukov verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 63(2018), 1, Seite 28-33 (DE-627)1043470638 25002228 nnns volume:63 year:2018 number:1 pages:28-33 https://doi.org/10.21508/1027-4065-2018-63-1-28-33 kostenfrei https://doaj.org/article/6c96d094c5964891b8ea8522f8fd240b kostenfrei https://www.ped-perinatology.ru/jour/article/view/615 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 1 28-33 |
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10.21508/1027-4065-2018-63-1-28-33 doi (DE-627)DOAJ033874735 (DE-599)DOAJ6c96d094c5964891b8ea8522f8fd240b DE-627 ger DE-627 rakwb rus RJ1-570 E. E. Varlamov verfasserin aut The importance of cytokines for the atopic dermatitis pathogenesis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. дети атопический дерматит патогенез цитокины Pediatrics A. N. Pampura verfasserin aut V. S. Sukhorukov verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 63(2018), 1, Seite 28-33 (DE-627)1043470638 25002228 nnns volume:63 year:2018 number:1 pages:28-33 https://doi.org/10.21508/1027-4065-2018-63-1-28-33 kostenfrei https://doaj.org/article/6c96d094c5964891b8ea8522f8fd240b kostenfrei https://www.ped-perinatology.ru/jour/article/view/615 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 1 28-33 |
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10.21508/1027-4065-2018-63-1-28-33 doi (DE-627)DOAJ033874735 (DE-599)DOAJ6c96d094c5964891b8ea8522f8fd240b DE-627 ger DE-627 rakwb rus RJ1-570 E. E. Varlamov verfasserin aut The importance of cytokines for the atopic dermatitis pathogenesis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. дети атопический дерматит патогенез цитокины Pediatrics A. N. Pampura verfasserin aut V. S. Sukhorukov verfasserin aut In Rossijskij Vestnik Perinatologii i Pediatrii Ltd. “The National Academy of Pediatric Science and Innovation”, 2018 63(2018), 1, Seite 28-33 (DE-627)1043470638 25002228 nnns volume:63 year:2018 number:1 pages:28-33 https://doi.org/10.21508/1027-4065-2018-63-1-28-33 kostenfrei https://doaj.org/article/6c96d094c5964891b8ea8522f8fd240b kostenfrei https://www.ped-perinatology.ru/jour/article/view/615 kostenfrei https://doaj.org/toc/1027-4065 Journal toc kostenfrei https://doaj.org/toc/2500-2228 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 63 2018 1 28-33 |
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The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. |
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The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. |
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The atopic dermatitis is a chronic inflammatory skin disease. The wide disease prevalence, increase in a number of the severe forms determine its high medical and social importance. The development of the dermatic inflammatory process in the patients is caused by the complex interaction of the genetic mechanisms, environmental factors, infectious agents, defects of the skin barrier and immunologic mechanisms. The various populations of the immunocompetent cells takes participation in the atopic dermatitis immunopathogenesis: Th1, Th2, Th9, Тh17, Th22, regulatory T-cells and cytokines secreted by them. This review states the data on the participation of a number of cytokines in the development of the immunopathological process in the presence of the atopic dermatitis. The revealing of the particularities of the disease pathogenesis based on the cytokine profile assessment and determination of the clinical course severity markers are the most relevant line of the clinical allergology and immunology for determination not only the disease prognosis but for the therapeutic targets in future as well. |
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score |
7.403097 |