Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line

Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we ev...
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Gespeichert in:

Autor*in:	Mohammad Foad Heidary [verfasserIn] Hamideh Mahmoodzadeh Hosseini [verfasserIn] Elnaz Mehdizadeh Aghdam [verfasserIn] Mohammad Reza Nourani [verfasserIn] Reza Ranjbar [verfasserIn] Reza Mirnejad [verfasserIn] Abbas Ali Imani Fooladi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B

Übergeordnetes Werk:	In: Advanced Pharmaceutical Bulletin - Tabriz University of Medical Sciences, 2011, 5(2015), 2, Seite 255-259
Übergeordnetes Werk:	volume:5 ; year:2015 ; number:2 ; pages:255-259

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.15171/apb.2015.035

Katalog-ID:	DOAJ033915326

Internformat


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allfields	10.15171/apb.2015.035 doi (DE-627)DOAJ033915326 (DE-599)DOAJc3180f7442cd4d65a9170cb81c87a3f9 DE-627 ger DE-627 rakwb eng RM1-950 Mohammad Foad Heidary verfasserin aut Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis. Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B Therapeutics. Pharmacology Hamideh Mahmoodzadeh Hosseini verfasserin aut Elnaz Mehdizadeh Aghdam verfasserin aut Mohammad Reza Nourani verfasserin aut Reza Ranjbar verfasserin aut Reza Mirnejad verfasserin aut Abbas Ali Imani Fooladi verfasserin aut In Advanced Pharmaceutical Bulletin Tabriz University of Medical Sciences, 2011 5(2015), 2, Seite 255-259 (DE-627)169603163X 22517308 nnns volume:5 year:2015 number:2 pages:255-259 https://doi.org/10.15171/apb.2015.035 kostenfrei https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 kostenfrei http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf kostenfrei https://doaj.org/toc/2228-5881 Journal toc kostenfrei https://doaj.org/toc/2251-7308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015 2 255-259
spelling	10.15171/apb.2015.035 doi (DE-627)DOAJ033915326 (DE-599)DOAJc3180f7442cd4d65a9170cb81c87a3f9 DE-627 ger DE-627 rakwb eng RM1-950 Mohammad Foad Heidary verfasserin aut Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis. Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B Therapeutics. Pharmacology Hamideh Mahmoodzadeh Hosseini verfasserin aut Elnaz Mehdizadeh Aghdam verfasserin aut Mohammad Reza Nourani verfasserin aut Reza Ranjbar verfasserin aut Reza Mirnejad verfasserin aut Abbas Ali Imani Fooladi verfasserin aut In Advanced Pharmaceutical Bulletin Tabriz University of Medical Sciences, 2011 5(2015), 2, Seite 255-259 (DE-627)169603163X 22517308 nnns volume:5 year:2015 number:2 pages:255-259 https://doi.org/10.15171/apb.2015.035 kostenfrei https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 kostenfrei http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf kostenfrei https://doaj.org/toc/2228-5881 Journal toc kostenfrei https://doaj.org/toc/2251-7308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015 2 255-259
allfields_unstemmed	10.15171/apb.2015.035 doi (DE-627)DOAJ033915326 (DE-599)DOAJc3180f7442cd4d65a9170cb81c87a3f9 DE-627 ger DE-627 rakwb eng RM1-950 Mohammad Foad Heidary verfasserin aut Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis. Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B Therapeutics. Pharmacology Hamideh Mahmoodzadeh Hosseini verfasserin aut Elnaz Mehdizadeh Aghdam verfasserin aut Mohammad Reza Nourani verfasserin aut Reza Ranjbar verfasserin aut Reza Mirnejad verfasserin aut Abbas Ali Imani Fooladi verfasserin aut In Advanced Pharmaceutical Bulletin Tabriz University of Medical Sciences, 2011 5(2015), 2, Seite 255-259 (DE-627)169603163X 22517308 nnns volume:5 year:2015 number:2 pages:255-259 https://doi.org/10.15171/apb.2015.035 kostenfrei https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 kostenfrei http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf kostenfrei https://doaj.org/toc/2228-5881 Journal toc kostenfrei https://doaj.org/toc/2251-7308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015 2 255-259
allfieldsGer	10.15171/apb.2015.035 doi (DE-627)DOAJ033915326 (DE-599)DOAJc3180f7442cd4d65a9170cb81c87a3f9 DE-627 ger DE-627 rakwb eng RM1-950 Mohammad Foad Heidary verfasserin aut Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis. Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B Therapeutics. Pharmacology Hamideh Mahmoodzadeh Hosseini verfasserin aut Elnaz Mehdizadeh Aghdam verfasserin aut Mohammad Reza Nourani verfasserin aut Reza Ranjbar verfasserin aut Reza Mirnejad verfasserin aut Abbas Ali Imani Fooladi verfasserin aut In Advanced Pharmaceutical Bulletin Tabriz University of Medical Sciences, 2011 5(2015), 2, Seite 255-259 (DE-627)169603163X 22517308 nnns volume:5 year:2015 number:2 pages:255-259 https://doi.org/10.15171/apb.2015.035 kostenfrei https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 kostenfrei http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf kostenfrei https://doaj.org/toc/2228-5881 Journal toc kostenfrei https://doaj.org/toc/2251-7308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015 2 255-259
allfieldsSound	10.15171/apb.2015.035 doi (DE-627)DOAJ033915326 (DE-599)DOAJc3180f7442cd4d65a9170cb81c87a3f9 DE-627 ger DE-627 rakwb eng RM1-950 Mohammad Foad Heidary verfasserin aut Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis. Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B Therapeutics. Pharmacology Hamideh Mahmoodzadeh Hosseini verfasserin aut Elnaz Mehdizadeh Aghdam verfasserin aut Mohammad Reza Nourani verfasserin aut Reza Ranjbar verfasserin aut Reza Mirnejad verfasserin aut Abbas Ali Imani Fooladi verfasserin aut In Advanced Pharmaceutical Bulletin Tabriz University of Medical Sciences, 2011 5(2015), 2, Seite 255-259 (DE-627)169603163X 22517308 nnns volume:5 year:2015 number:2 pages:255-259 https://doi.org/10.15171/apb.2015.035 kostenfrei https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 kostenfrei http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf kostenfrei https://doaj.org/toc/2228-5881 Journal toc kostenfrei https://doaj.org/toc/2251-7308 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2015 2 255-259
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callnumber-first	R - Medicine
author	Mohammad Foad Heidary
spellingShingle	Mohammad Foad Heidary misc RM1-950 misc Breast Cancer misc Metastasis misc Mir - 335 misc Mir - 10b misc Staphylococcal Enterotoxin B misc Therapeutics. Pharmacology Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line
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topic_title	RM1-950 Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line Breast Cancer Metastasis Mir - 335 Mir - 10b Staphylococcal Enterotoxin B
topic	misc RM1-950 misc Breast Cancer misc Metastasis misc Mir - 335 misc Mir - 10b misc Staphylococcal Enterotoxin B misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Breast Cancer misc Metastasis misc Mir - 335 misc Mir - 10b misc Staphylococcal Enterotoxin B misc Therapeutics. Pharmacology
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title	Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line
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title_full	Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line
author_sort	Mohammad Foad Heidary
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author_browse	Mohammad Foad Heidary Hamideh Mahmoodzadeh Hosseini Elnaz Mehdizadeh Aghdam Mohammad Reza Nourani Reza Ranjbar Reza Mirnejad Abbas Ali Imani Fooladi
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title_sort	overexpression of metastatic related micrornas, mir-335 and mir-10b, by staphylococcal enterotoxin b in the metastatic breast cancer cell line
callnumber	RM1-950
title_auth	Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line
abstract	Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis.
abstractGer	Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis.
abstract_unstemmed	Purpose : One of the advanced cancer therapy strategies is immune - stimulating compound based immunotherapy Staphylococcal enterotoxin B (SEB) is one of the potent superantigens, which can efficiently activate antitumor immune response to eradicate tumor growth and inhibit metastasis. Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. Our results suggest that SEB probably induces its anti - m etastatic effect via the expression regulation of the main genes which contributes to metastasis.
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title_short	Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line
url	https://doi.org/10.15171/apb.2015.035 https://doaj.org/article/c3180f7442cd4d65a9170cb81c87a3f9 http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-255.pdf https://doaj.org/toc/2228-5881 https://doaj.org/toc/2251-7308
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up_date	2024-07-03T20:21:39.199Z
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Herein, we evaluated the effect of SEB on the expression of two master microRN As, mir - 335 and mir - 10b, involved in metastasis. Methods : A metastatic breast cancer cell line MDA - MB231was treated with four different concentrations of SEB, including 10, 10 2 , 10 3 and 10 4 ng/ml, for 24 and 48 hours. To identify the cytotoxic effect of S EB, treated cells were examined by MTT assay. The stem loop RT - PCR (TaqMan) was used to analyze the mir - 335 and mir - 10b expression. Results : Results showed that SEB significantly increased the expression of mir - 335 both after 24 and 48 hours ( p v < 0.001 and p v < 0.05, respectively). No significant differences were found in the mir - 10b expression. Conclusion : Moreover, our findings demonstrated no cytotoxic effect of SEB on the treated cells. 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Overexpression of Metastatic Related MicroRNAs, Mir-335 and Mir-10b, by Staphylococcal Enterotoxin B in the Metastatic Breast Cancer Cell Line

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