Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells

Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmissio...
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Autor*in:	Saba M. Alsubaie [verfasserIn] Daoud Ali [verfasserIn] Bader O. Almutairi [verfasserIn] Rafa Almeer [verfasserIn] Saud Alarifi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Dose-Response - SAGE Publishing, 2015, 20(2022)
Übergeordnetes Werk:	volume:20 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/15593258221128428

Katalog-ID:	DOAJ034020527

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allfields	10.1177/15593258221128428 doi (DE-627)DOAJ034020527 (DE-599)DOAJ2e2fe773681c480497f1a65b10f663e1 DE-627 ger DE-627 rakwb eng RM1-950 Saba M. Alsubaie verfasserin aut Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs. Therapeutics. Pharmacology Daoud Ali verfasserin aut Bader O. Almutairi verfasserin aut Rafa Almeer verfasserin aut Saud Alarifi verfasserin aut In Dose-Response SAGE Publishing, 2015 20(2022) (DE-627)573743592 (DE-600)2440820-7 15593258 nnns volume:20 year:2022 https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/article/2e2fe773681c480497f1a65b10f663e1 kostenfrei https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/toc/1559-3258 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022
spelling	10.1177/15593258221128428 doi (DE-627)DOAJ034020527 (DE-599)DOAJ2e2fe773681c480497f1a65b10f663e1 DE-627 ger DE-627 rakwb eng RM1-950 Saba M. Alsubaie verfasserin aut Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs. Therapeutics. Pharmacology Daoud Ali verfasserin aut Bader O. Almutairi verfasserin aut Rafa Almeer verfasserin aut Saud Alarifi verfasserin aut In Dose-Response SAGE Publishing, 2015 20(2022) (DE-627)573743592 (DE-600)2440820-7 15593258 nnns volume:20 year:2022 https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/article/2e2fe773681c480497f1a65b10f663e1 kostenfrei https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/toc/1559-3258 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022
allfields_unstemmed	10.1177/15593258221128428 doi (DE-627)DOAJ034020527 (DE-599)DOAJ2e2fe773681c480497f1a65b10f663e1 DE-627 ger DE-627 rakwb eng RM1-950 Saba M. Alsubaie verfasserin aut Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs. Therapeutics. Pharmacology Daoud Ali verfasserin aut Bader O. Almutairi verfasserin aut Rafa Almeer verfasserin aut Saud Alarifi verfasserin aut In Dose-Response SAGE Publishing, 2015 20(2022) (DE-627)573743592 (DE-600)2440820-7 15593258 nnns volume:20 year:2022 https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/article/2e2fe773681c480497f1a65b10f663e1 kostenfrei https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/toc/1559-3258 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022
allfieldsGer	10.1177/15593258221128428 doi (DE-627)DOAJ034020527 (DE-599)DOAJ2e2fe773681c480497f1a65b10f663e1 DE-627 ger DE-627 rakwb eng RM1-950 Saba M. Alsubaie verfasserin aut Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs. Therapeutics. Pharmacology Daoud Ali verfasserin aut Bader O. Almutairi verfasserin aut Rafa Almeer verfasserin aut Saud Alarifi verfasserin aut In Dose-Response SAGE Publishing, 2015 20(2022) (DE-627)573743592 (DE-600)2440820-7 15593258 nnns volume:20 year:2022 https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/article/2e2fe773681c480497f1a65b10f663e1 kostenfrei https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/toc/1559-3258 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022
allfieldsSound	10.1177/15593258221128428 doi (DE-627)DOAJ034020527 (DE-599)DOAJ2e2fe773681c480497f1a65b10f663e1 DE-627 ger DE-627 rakwb eng RM1-950 Saba M. Alsubaie verfasserin aut Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs. Therapeutics. Pharmacology Daoud Ali verfasserin aut Bader O. Almutairi verfasserin aut Rafa Almeer verfasserin aut Saud Alarifi verfasserin aut In Dose-Response SAGE Publishing, 2015 20(2022) (DE-627)573743592 (DE-600)2440820-7 15593258 nnns volume:20 year:2022 https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/article/2e2fe773681c480497f1a65b10f663e1 kostenfrei https://doi.org/10.1177/15593258221128428 kostenfrei https://doaj.org/toc/1559-3258 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2022
language	English
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author	Saba M. Alsubaie
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title	Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells
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title_full	Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells
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title_sort	evaluation of cyto - and genotoxic influence of lanthanum dioxide nanoparticles on human liver cells
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title_auth	Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells
abstract	Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs.
abstractGer	Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs.
abstract_unstemmed	Inorganic nanoparticles are representing an emerging paradigm in molecular imaging probe design. We have determined lanthanum oxide nanoparticles (La 2 O 3 NPs)-induced toxicity on human livers cells for 48 hrs. Before exposure to La 2 O 3 NPs, the size and shape of NPs were confirmed by transmission electron microscope. It was found at 32 ±1.6 nm with a sheet-like morphological structure. The viability of CHANG and HuH-7 cells was reduced as the concentration of La 2 O 3 NPs increased. HuH-7 cells were more sensitive than CHANG cells to La 2 O 3 NPs. We observed production of intracellular ROS in HuH-7 cells was more than CHANG cells and the LPO level was more in CHANG cells than in HuH-7 cells at 50 μg/ml of La 2 O 3 NPs. Glutathione was decreased and catalase was increased at 50 μg/ml of La 2 O 3 NPs. More apoptotic and necrotic cells were observed at 300 μg/ml in HuH-7 cells FACS. DNA damage was observed by the SGCE test and more DNA damage was found in CHANG cells than HuH-7 cells at 300 μg/ml La 2 O 3 NPs over 48 hrs. Thus, study warrants the application of La 2 O 3 NPs in daily life and provides vital information about the toxicity of La 2 O 3 NPs.
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title_short	Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells
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doi_str	10.1177/15593258221128428
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up_date	2024-07-03T20:57:34.472Z
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Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells

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