Immunotherapy in Squamous Cell Cancer of the Esophagus

Treatment of esophageal carcinoma has changed dramatically following several landmark trials, which have proven the benefit of immunotherapy. The selective PD-1 (programmed cell death ligand-1)-inhibitor nivolumab has been shown to improve DFS in the adjuvant therapy setting (CheckMate-577). In the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Peter Thuss-Patience [verfasserIn] Alexander Stein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	immunotherapy esophagus squamous cell carcinoma ESCC checkpoint inhibitor

Übergeordnetes Werk:	In: Current Oncology - MDPI AG, 2021, 29(2022), 4, Seite 2461-2471
Übergeordnetes Werk:	volume:29 ; year:2022 ; number:4 ; pages:2461-2471

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/curroncol29040200

Katalog-ID:	DOAJ034084061

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source	In Current Oncology 29(2022), 4, Seite 2461-2471 volume:29 year:2022 number:4 pages:2461-2471
sourceStr	In Current Oncology 29(2022), 4, Seite 2461-2471 volume:29 year:2022 number:4 pages:2461-2471
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topic_facet	immunotherapy esophagus squamous cell carcinoma ESCC checkpoint inhibitor Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Current Oncology
authorswithroles_txt_mv	Peter Thuss-Patience @@aut@@ Alexander Stein @@aut@@
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callnumber-first	R - Medicine
author	Peter Thuss-Patience
spellingShingle	Peter Thuss-Patience misc RC254-282 misc immunotherapy misc esophagus misc squamous cell carcinoma misc ESCC misc checkpoint inhibitor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunotherapy in Squamous Cell Cancer of the Esophagus
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topic_title	RC254-282 Immunotherapy in Squamous Cell Cancer of the Esophagus immunotherapy esophagus squamous cell carcinoma ESCC checkpoint inhibitor
topic	misc RC254-282 misc immunotherapy misc esophagus misc squamous cell carcinoma misc ESCC misc checkpoint inhibitor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc immunotherapy misc esophagus misc squamous cell carcinoma misc ESCC misc checkpoint inhibitor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc immunotherapy misc esophagus misc squamous cell carcinoma misc ESCC misc checkpoint inhibitor misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Immunotherapy in Squamous Cell Cancer of the Esophagus
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title_full	Immunotherapy in Squamous Cell Cancer of the Esophagus
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title_sort	immunotherapy in squamous cell cancer of the esophagus
callnumber	RC254-282
title_auth	Immunotherapy in Squamous Cell Cancer of the Esophagus
abstract	Treatment of esophageal carcinoma has changed dramatically following several landmark trials, which have proven the benefit of immunotherapy. The selective PD-1 (programmed cell death ligand-1)-inhibitor nivolumab has been shown to improve DFS in the adjuvant therapy setting (CheckMate-577). In the first-line treatment, PD-L1 positive (CPS ≥ 10) squamous cell carcinoma patients (pts) have been shown to have an increased OS following treatment with the PD-1-inhibitor pembrolizumab in combination with chemotherapy (KEYNOTE-590). Nivolumab also improved overall survival in the first line setting either combined with ipilimumab or with chemotherapy (CheckMate 648) compared to chemotherapy alone. In Asian first-line patients, phase III trials investigating camrelizumab (ESCORT 1), toripalimab (JUPITER 06), or sintilimab (ORIENT 15) in addition to chemotherapy also showed significant survival benefits. In the second-line setting, monotherapy with nivolumab (ATTRACTION-03), pembrolizumab (KEYNOTE-181), camrelizumab (ESCORT), and tislelizumab (RATIONALE 302) demonstrated a benefit in OS in comparison to chemotherapy. Here we will review these trials and integrate them into the current treatment algorithm.
abstractGer	Treatment of esophageal carcinoma has changed dramatically following several landmark trials, which have proven the benefit of immunotherapy. The selective PD-1 (programmed cell death ligand-1)-inhibitor nivolumab has been shown to improve DFS in the adjuvant therapy setting (CheckMate-577). In the first-line treatment, PD-L1 positive (CPS ≥ 10) squamous cell carcinoma patients (pts) have been shown to have an increased OS following treatment with the PD-1-inhibitor pembrolizumab in combination with chemotherapy (KEYNOTE-590). Nivolumab also improved overall survival in the first line setting either combined with ipilimumab or with chemotherapy (CheckMate 648) compared to chemotherapy alone. In Asian first-line patients, phase III trials investigating camrelizumab (ESCORT 1), toripalimab (JUPITER 06), or sintilimab (ORIENT 15) in addition to chemotherapy also showed significant survival benefits. In the second-line setting, monotherapy with nivolumab (ATTRACTION-03), pembrolizumab (KEYNOTE-181), camrelizumab (ESCORT), and tislelizumab (RATIONALE 302) demonstrated a benefit in OS in comparison to chemotherapy. Here we will review these trials and integrate them into the current treatment algorithm.
abstract_unstemmed	Treatment of esophageal carcinoma has changed dramatically following several landmark trials, which have proven the benefit of immunotherapy. The selective PD-1 (programmed cell death ligand-1)-inhibitor nivolumab has been shown to improve DFS in the adjuvant therapy setting (CheckMate-577). In the first-line treatment, PD-L1 positive (CPS ≥ 10) squamous cell carcinoma patients (pts) have been shown to have an increased OS following treatment with the PD-1-inhibitor pembrolizumab in combination with chemotherapy (KEYNOTE-590). Nivolumab also improved overall survival in the first line setting either combined with ipilimumab or with chemotherapy (CheckMate 648) compared to chemotherapy alone. In Asian first-line patients, phase III trials investigating camrelizumab (ESCORT 1), toripalimab (JUPITER 06), or sintilimab (ORIENT 15) in addition to chemotherapy also showed significant survival benefits. In the second-line setting, monotherapy with nivolumab (ATTRACTION-03), pembrolizumab (KEYNOTE-181), camrelizumab (ESCORT), and tislelizumab (RATIONALE 302) demonstrated a benefit in OS in comparison to chemotherapy. Here we will review these trials and integrate them into the current treatment algorithm.
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title_short	Immunotherapy in Squamous Cell Cancer of the Esophagus
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up_date	2024-07-03T21:19:23.650Z
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