Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling

<p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal s...
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Autor*in:	Joyce Eileen M [verfasserIn] Sahakian Barbara J [verfasserIn] Hynes Fiona [verfasserIn] Blackwell Candice [verfasserIn] Jaycock Sue [verfasserIn] Croudace Tim J [verfasserIn] Barnett Jennifer H [verfasserIn] Jones Peter B [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Übergeordnetes Werk:	In: BMC Psychiatry - BMC, 2003, 7(2007), 1, p 16
Übergeordnetes Werk:	volume:7 ; year:2007 ; number:1, p 16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-244X-7-16

Katalog-ID:	DOAJ034409246

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spelling	10.1186/1471-244X-7-16 doi (DE-627)DOAJ034409246 (DE-599)DOAJ43539a4fb78a4e00a661b32518cbeb2e DE-627 ger DE-627 rakwb eng RC435-571 Joyce Eileen M verfasserin aut Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p< Psychiatry Sahakian Barbara J verfasserin aut Hynes Fiona verfasserin aut Blackwell Candice verfasserin aut Jaycock Sue verfasserin aut Croudace Tim J verfasserin aut Barnett Jennifer H verfasserin aut Jones Peter B verfasserin aut In BMC Psychiatry BMC, 2003 7(2007), 1, p 16 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:7 year:2007 number:1, p 16 https://doi.org/10.1186/1471-244X-7-16 kostenfrei https://doaj.org/article/43539a4fb78a4e00a661b32518cbeb2e kostenfrei http://www.biomedcentral.com/1471-244X/7/16 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 16
allfields_unstemmed	10.1186/1471-244X-7-16 doi (DE-627)DOAJ034409246 (DE-599)DOAJ43539a4fb78a4e00a661b32518cbeb2e DE-627 ger DE-627 rakwb eng RC435-571 Joyce Eileen M verfasserin aut Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p< Psychiatry Sahakian Barbara J verfasserin aut Hynes Fiona verfasserin aut Blackwell Candice verfasserin aut Jaycock Sue verfasserin aut Croudace Tim J verfasserin aut Barnett Jennifer H verfasserin aut Jones Peter B verfasserin aut In BMC Psychiatry BMC, 2003 7(2007), 1, p 16 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:7 year:2007 number:1, p 16 https://doi.org/10.1186/1471-244X-7-16 kostenfrei https://doaj.org/article/43539a4fb78a4e00a661b32518cbeb2e kostenfrei http://www.biomedcentral.com/1471-244X/7/16 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 16
allfieldsGer	10.1186/1471-244X-7-16 doi (DE-627)DOAJ034409246 (DE-599)DOAJ43539a4fb78a4e00a661b32518cbeb2e DE-627 ger DE-627 rakwb eng RC435-571 Joyce Eileen M verfasserin aut Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p< Psychiatry Sahakian Barbara J verfasserin aut Hynes Fiona verfasserin aut Blackwell Candice verfasserin aut Jaycock Sue verfasserin aut Croudace Tim J verfasserin aut Barnett Jennifer H verfasserin aut Jones Peter B verfasserin aut In BMC Psychiatry BMC, 2003 7(2007), 1, p 16 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:7 year:2007 number:1, p 16 https://doi.org/10.1186/1471-244X-7-16 kostenfrei https://doaj.org/article/43539a4fb78a4e00a661b32518cbeb2e kostenfrei http://www.biomedcentral.com/1471-244X/7/16 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 16
allfieldsSound	10.1186/1471-244X-7-16 doi (DE-627)DOAJ034409246 (DE-599)DOAJ43539a4fb78a4e00a661b32518cbeb2e DE-627 ger DE-627 rakwb eng RC435-571 Joyce Eileen M verfasserin aut Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p< Psychiatry Sahakian Barbara J verfasserin aut Hynes Fiona verfasserin aut Blackwell Candice verfasserin aut Jaycock Sue verfasserin aut Croudace Tim J verfasserin aut Barnett Jennifer H verfasserin aut Jones Peter B verfasserin aut In BMC Psychiatry BMC, 2003 7(2007), 1, p 16 (DE-627)331018799 (DE-600)2050438-X 1471244X nnns volume:7 year:2007 number:1, p 16 https://doi.org/10.1186/1471-244X-7-16 kostenfrei https://doaj.org/article/43539a4fb78a4e00a661b32518cbeb2e kostenfrei http://www.biomedcentral.com/1471-244X/7/16 kostenfrei https://doaj.org/toc/1471-244X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2007 1, p 16
language	English
source	In BMC Psychiatry 7(2007), 1, p 16 volume:7 year:2007 number:1, p 16
sourceStr	In BMC Psychiatry 7(2007), 1, p 16 volume:7 year:2007 number:1, p 16
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Psychiatry
isfreeaccess_bool	true
container_title	BMC Psychiatry
authorswithroles_txt_mv	Joyce Eileen M @@aut@@ Sahakian Barbara J @@aut@@ Hynes Fiona @@aut@@ Blackwell Candice @@aut@@ Jaycock Sue @@aut@@ Croudace Tim J @@aut@@ Barnett Jennifer H @@aut@@ Jones Peter B @@aut@@
publishDateDaySort_date	2007-01-01T00:00:00Z
hierarchy_top_id	331018799
id	DOAJ034409246
language_de	englisch
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callnumber-first	R - Medicine
author	Joyce Eileen M
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topic_title	RC435-571 Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling
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title	Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling
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title_full	Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling
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author_browse	Joyce Eileen M Sahakian Barbara J Hynes Fiona Blackwell Candice Jaycock Sue Croudace Tim J Barnett Jennifer H Jones Peter B
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title_sort	improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling
callnumber	RC435-571
title_auth	Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling
abstract	<p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Long-term follow-up studies of people with schizophrenia report stability of cognitive performance; less is known about any shorter-term changes in cognitive function.</p< <p<Methods</p< <p<This longitudinal study aimed to establish whether there was stability, improvement or decline in memory and executive functions over four assessments undertaken prospectively in one year. Cognitive performance was assessed during randomized controlled trials of first- and second-generation antipsychotic medication. Analyses used a latent growth modeling approach, so that individuals who missed some testing occasions could be included and trajectories of cognitive change explored despite missing data.</p< <p<Results</p< <p<Over the year there was significant decline in spatial recognition but no change in pattern recognition or motor speed. Improvement was seen in planning and spatial working memory tasks; this may reflect improved strategy use with practice. There were significant individual differences in the initial level of performance on all tasks but not in rate of change; the latter may have been due to sample size limitations. Age, sex, premorbid IQ and drug class allocation explained significant variation in level of performance but could not predict change. Patients randomized to first-generation drugs improved more quickly than other groups on the planning task.</p< <p<Conclusion</p< <p<We conclude that cognitive change is present in schizophrenia but the magnitude of change is small when compared with the large differences in cognitive function that exist between patients. Analyses that retain patients who drop out of longitudinal studies, as well as those who complete testing protocols, are important to our understanding of cognition in schizophrenia.</p<
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Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling

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