Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis?
Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mudduwa LKB [verfasserIn] Wijayaratne GB [verfasserIn] Peiris HH [verfasserIn] Gunasekera SN [verfasserIn] Abeysiriwardhana D [verfasserIn] Liyanage N [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Übergeordnetes Werk: |
In: International Journal of Women's Health - Dove Medical Press, 2009, (2018), Seite 329-335 |
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| Übergeordnetes Werk: |
year:2018 ; pages:329-335 |
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| 520 | |a Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis | ||
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(DE-627)DOAJ034454780 (DE-599)DOAJ5315a1cc1a934730b07ce7439b36e6df DE-627 ger DE-627 rakwb eng RG1-991 Mudduwa LKB verfasserin aut Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis Breast cancer pre-surgical CA15-3 short term disease free survival Gynecology and obstetrics Wijayaratne GB verfasserin aut Peiris HH verfasserin aut Gunasekera SN verfasserin aut Abeysiriwardhana D verfasserin aut Liyanage N verfasserin aut In International Journal of Women's Health Dove Medical Press, 2009 (2018), Seite 329-335 (DE-627)606031936 (DE-600)2508161-5 11791411 nnns year:2018 pages:329-335 https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df kostenfrei https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH kostenfrei https://doaj.org/toc/1179-1411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 329-335 |
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(DE-627)DOAJ034454780 (DE-599)DOAJ5315a1cc1a934730b07ce7439b36e6df DE-627 ger DE-627 rakwb eng RG1-991 Mudduwa LKB verfasserin aut Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis Breast cancer pre-surgical CA15-3 short term disease free survival Gynecology and obstetrics Wijayaratne GB verfasserin aut Peiris HH verfasserin aut Gunasekera SN verfasserin aut Abeysiriwardhana D verfasserin aut Liyanage N verfasserin aut In International Journal of Women's Health Dove Medical Press, 2009 (2018), Seite 329-335 (DE-627)606031936 (DE-600)2508161-5 11791411 nnns year:2018 pages:329-335 https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df kostenfrei https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH kostenfrei https://doaj.org/toc/1179-1411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 329-335 |
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(DE-627)DOAJ034454780 (DE-599)DOAJ5315a1cc1a934730b07ce7439b36e6df DE-627 ger DE-627 rakwb eng RG1-991 Mudduwa LKB verfasserin aut Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis Breast cancer pre-surgical CA15-3 short term disease free survival Gynecology and obstetrics Wijayaratne GB verfasserin aut Peiris HH verfasserin aut Gunasekera SN verfasserin aut Abeysiriwardhana D verfasserin aut Liyanage N verfasserin aut In International Journal of Women's Health Dove Medical Press, 2009 (2018), Seite 329-335 (DE-627)606031936 (DE-600)2508161-5 11791411 nnns year:2018 pages:329-335 https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df kostenfrei https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH kostenfrei https://doaj.org/toc/1179-1411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 329-335 |
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(DE-627)DOAJ034454780 (DE-599)DOAJ5315a1cc1a934730b07ce7439b36e6df DE-627 ger DE-627 rakwb eng RG1-991 Mudduwa LKB verfasserin aut Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis Breast cancer pre-surgical CA15-3 short term disease free survival Gynecology and obstetrics Wijayaratne GB verfasserin aut Peiris HH verfasserin aut Gunasekera SN verfasserin aut Abeysiriwardhana D verfasserin aut Liyanage N verfasserin aut In International Journal of Women's Health Dove Medical Press, 2009 (2018), Seite 329-335 (DE-627)606031936 (DE-600)2508161-5 11791411 nnns year:2018 pages:329-335 https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df kostenfrei https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH kostenfrei https://doaj.org/toc/1179-1411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 329-335 |
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(DE-627)DOAJ034454780 (DE-599)DOAJ5315a1cc1a934730b07ce7439b36e6df DE-627 ger DE-627 rakwb eng RG1-991 Mudduwa LKB verfasserin aut Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis Breast cancer pre-surgical CA15-3 short term disease free survival Gynecology and obstetrics Wijayaratne GB verfasserin aut Peiris HH verfasserin aut Gunasekera SN verfasserin aut Abeysiriwardhana D verfasserin aut Liyanage N verfasserin aut In International Journal of Women's Health Dove Medical Press, 2009 (2018), Seite 329-335 (DE-627)606031936 (DE-600)2508161-5 11791411 nnns year:2018 pages:329-335 https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df kostenfrei https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH kostenfrei https://doaj.org/toc/1179-1411 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 329-335 |
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Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis |
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Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis |
| abstract_unstemmed |
Lakmini KB Mudduwa,1 Gaya B Wijayaratne,2 Harshini H Peiris,3 Shania N Gunasekera,1 Deepthika Abeysiriwardhana,1 Nimsha Liyanage1 1Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 2Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; 3Medical Laboratory Science Degree Program, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka Background: CA15-3 is the most commonly used tumor marker in breast cancer. Its prognostic role has been described in the metastatic setting, but the role of pre-surgical CA15-3 in the assessment of patients with breast cancer without metastasis has not been substantiated yet. Methodology: From February 2014 for a 2-year period, this prospective study included all patients who were diagnosed with primary breast cancer and underwent surgery at a tertiary care hospital. The serum level of CA15-3 was assessed on a pre-surgical blood sample and later at the 3-, 6-, 9-, and 12-month follow-up by enzyme-linked immunosorbent assay. Disease-free survival (DFS) was analyzed with a Kaplan–Meier model and log-rank test. Results: We enrolled 195 patients (mean age +- SD 57.84 years +-13.819, range, 28–95) with breast cancer. The prevalence of elevated (≥30 U/mL) pre-surgical CA15-3 was 35.9%, and it reduced to 14.3% at 3 months after mastectomy. Pre-surgical CA15-3 had a significant association only with the size of the tumor (p=0.047). Patients who did not have elevated pre-surgical CA15-3 (≥30 U/mL) had the best short-term DFS, and it was worst when the pre-surgical CA15-3 was >100 U/mL (p=0.041). Conclusion: Elevated pre-surgical CA15-3 is a predictor of poor short-term DFS of patients with breast cancer without distant metastasis. Keywords: breast cancer, pre-surgical CA15-3, short-term disease-free survival, prognosis |
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Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis? |
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https://doaj.org/article/5315a1cc1a934730b07ce7439b36e6df https://www.dovepress.com/elevated-pre-surgical-ca15-3-does-it-predict-the-short-term-disease-fr-peer-reviewed-article-IJWH https://doaj.org/toc/1179-1411 |
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