Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome

<p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Cui Ai-dong [verfasserIn] Gai Ning-ning [verfasserIn] Zhang Xiu-hua [verfasserIn] Jia Ke-zhi [verfasserIn] Yang Yan-li [verfasserIn] Song Ze-jun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Obestatin Metabolic syndrome Carotid atherosclerosis

Übergeordnetes Werk:	In: Diabetology & Metabolic Syndrome - BMC, 2010, 4(2012), 1, p 52
Übergeordnetes Werk:	volume:4 ; year:2012 ; number:1, p 52

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1758-5996-4-52

Katalog-ID:	DOAJ034461566

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allfields	10.1186/1758-5996-4-52 doi (DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2 DE-627 ger DE-627 rakwb eng RC620-627 Cui Ai-dong verfasserin aut Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases Gai Ning-ning verfasserin aut Zhang Xiu-hua verfasserin aut Jia Ke-zhi verfasserin aut Yang Yan-li verfasserin aut Song Ze-jun verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 4(2012), 1, p 52 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:4 year:2012 number:1, p 52 https://doi.org/10.1186/1758-5996-4-52 kostenfrei https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 kostenfrei http://www.dmsjournal.com/content/4/1/52 kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 1, p 52
spelling	10.1186/1758-5996-4-52 doi (DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2 DE-627 ger DE-627 rakwb eng RC620-627 Cui Ai-dong verfasserin aut Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases Gai Ning-ning verfasserin aut Zhang Xiu-hua verfasserin aut Jia Ke-zhi verfasserin aut Yang Yan-li verfasserin aut Song Ze-jun verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 4(2012), 1, p 52 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:4 year:2012 number:1, p 52 https://doi.org/10.1186/1758-5996-4-52 kostenfrei https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 kostenfrei http://www.dmsjournal.com/content/4/1/52 kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 1, p 52
allfields_unstemmed	10.1186/1758-5996-4-52 doi (DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2 DE-627 ger DE-627 rakwb eng RC620-627 Cui Ai-dong verfasserin aut Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases Gai Ning-ning verfasserin aut Zhang Xiu-hua verfasserin aut Jia Ke-zhi verfasserin aut Yang Yan-li verfasserin aut Song Ze-jun verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 4(2012), 1, p 52 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:4 year:2012 number:1, p 52 https://doi.org/10.1186/1758-5996-4-52 kostenfrei https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 kostenfrei http://www.dmsjournal.com/content/4/1/52 kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 1, p 52
allfieldsGer	10.1186/1758-5996-4-52 doi (DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2 DE-627 ger DE-627 rakwb eng RC620-627 Cui Ai-dong verfasserin aut Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases Gai Ning-ning verfasserin aut Zhang Xiu-hua verfasserin aut Jia Ke-zhi verfasserin aut Yang Yan-li verfasserin aut Song Ze-jun verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 4(2012), 1, p 52 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:4 year:2012 number:1, p 52 https://doi.org/10.1186/1758-5996-4-52 kostenfrei https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 kostenfrei http://www.dmsjournal.com/content/4/1/52 kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 1, p 52
allfieldsSound	10.1186/1758-5996-4-52 doi (DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2 DE-627 ger DE-627 rakwb eng RC620-627 Cui Ai-dong verfasserin aut Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p< Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases Gai Ning-ning verfasserin aut Zhang Xiu-hua verfasserin aut Jia Ke-zhi verfasserin aut Yang Yan-li verfasserin aut Song Ze-jun verfasserin aut In Diabetology & Metabolic Syndrome BMC, 2010 4(2012), 1, p 52 (DE-627)610606689 (DE-600)2518786-7 17585996 nnns volume:4 year:2012 number:1, p 52 https://doi.org/10.1186/1758-5996-4-52 kostenfrei https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 kostenfrei http://www.dmsjournal.com/content/4/1/52 kostenfrei https://doaj.org/toc/1758-5996 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2012 1, p 52
language	English
source	In Diabetology & Metabolic Syndrome 4(2012), 1, p 52 volume:4 year:2012 number:1, p 52
sourceStr	In Diabetology & Metabolic Syndrome 4(2012), 1, p 52 volume:4 year:2012 number:1, p 52
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Diabetology & Metabolic Syndrome
authorswithroles_txt_mv	Cui Ai-dong @@aut@@ Gai Ning-ning @@aut@@ Zhang Xiu-hua @@aut@@ Jia Ke-zhi @@aut@@ Yang Yan-li @@aut@@ Song Ze-jun @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	610606689
id	DOAJ034461566
language_de	englisch
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Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. 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callnumber-first	R - Medicine
author	Cui Ai-dong
spellingShingle	Cui Ai-dong misc RC620-627 misc Obestatin misc <it<TRIB3</it< misc Metabolic syndrome misc Carotid atherosclerosis misc Nutritional diseases. Deficiency diseases Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
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topic_title	RC620-627 Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome Obestatin <it<TRIB3</it< Metabolic syndrome Carotid atherosclerosis
topic	misc RC620-627 misc Obestatin misc <it<TRIB3</it< misc Metabolic syndrome misc Carotid atherosclerosis misc Nutritional diseases. Deficiency diseases
topic_unstemmed	misc RC620-627 misc Obestatin misc <it<TRIB3</it< misc Metabolic syndrome misc Carotid atherosclerosis misc Nutritional diseases. Deficiency diseases
topic_browse	misc RC620-627 misc Obestatin misc <it<TRIB3</it< misc Metabolic syndrome misc Carotid atherosclerosis misc Nutritional diseases. Deficiency diseases
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hierarchy_parent_title	Diabetology & Metabolic Syndrome
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title	Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
ctrlnum	(DE-627)DOAJ034461566 (DE-599)DOAJ2a86ac5e8ee8470fb77e5fedf87e3af2
title_full	Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
author_sort	Cui Ai-dong
journal	Diabetology & Metabolic Syndrome
journalStr	Diabetology & Metabolic Syndrome
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lang_code	eng
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author_browse	Cui Ai-dong Gai Ning-ning Zhang Xiu-hua Jia Ke-zhi Yang Yan-li Song Ze-jun
container_volume	4
class	RC620-627
format_se	Elektronische Aufsätze
author-letter	Cui Ai-dong
doi_str_mv	10.1186/1758-5996-4-52
author2-role	verfasserin
title_sort	decreased serum obestatin consequent upon <it<trib3</it< q84r polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
callnumber	RC620-627
title_auth	Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
abstract	<p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Functional <it<TRIB3</it< Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent <it<TRIB3</it< Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.</p< <p<Methods</p< <p<A total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional <it<TRIB3</it< Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).</p< <p<Results</p< <p<Serum obestatin was significantly decreased in MetS as compared with the control group (<it<P</it< = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (<it<P</it< = 0.008, <it<P</it< = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (<it<P</it< = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (<it<r</it< = -0.163, <it<P</it< = 0.010) and IMT (<it<r</it< = -0.256, <it<P</it< = 0.011). On partial analyses, obestatin negatively correlated with IMT(<it<r</it< = -0.259, <it<P</it< = 0.024) after controlling for the confounding factors.</p< <p<Conclusion</p< <p<MetS individuals with <it<TRIB3</it< RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.</p<
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title_short	Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome
url	https://doi.org/10.1186/1758-5996-4-52 https://doaj.org/article/2a86ac5e8ee8470fb77e5fedf87e3af2 http://www.dmsjournal.com/content/4/1/52 https://doaj.org/toc/1758-5996
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Decreased serum obestatin consequent upon <it<TRIB3</it< Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome

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