Obtaining the Optimal Dose in Alcohol Dependence Studies

In alcohol dependence studies, the treatment effect at different dose levels remains to be ascertained. Establishing this effect would aid us in identifying the best dose that has satisfactory efficacy while minimizing the rate of adverse events. We advocate the use of dose-finding methodology that...
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Gespeichert in:

Autor*in:	Nolan A. Wages [verfasserIn] Lei eLiu [verfasserIn] John eO'Quigley [verfasserIn] Bankole eJohnson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Maximum Tolerated Dose alcohol research dose-finding most successful dose continual reassessment method

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 3(2012)
Übergeordnetes Werk:	volume:3 ; year:2012

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2012.00100

Katalog-ID:	DOAJ034473963

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author	Nolan A. Wages
spellingShingle	Nolan A. Wages misc RC435-571 misc Maximum Tolerated Dose misc alcohol research misc dose-finding misc most successful dose misc continual reassessment method misc Psychiatry Obtaining the Optimal Dose in Alcohol Dependence Studies
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topic_title	RC435-571 Obtaining the Optimal Dose in Alcohol Dependence Studies Maximum Tolerated Dose alcohol research dose-finding most successful dose continual reassessment method
topic	misc RC435-571 misc Maximum Tolerated Dose misc alcohol research misc dose-finding misc most successful dose misc continual reassessment method misc Psychiatry
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title	Obtaining the Optimal Dose in Alcohol Dependence Studies
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title_sort	obtaining the optimal dose in alcohol dependence studies
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title_auth	Obtaining the Optimal Dose in Alcohol Dependence Studies
abstract	In alcohol dependence studies, the treatment effect at different dose levels remains to be ascertained. Establishing this effect would aid us in identifying the best dose that has satisfactory efficacy while minimizing the rate of adverse events. We advocate the use of dose-finding methodology that has been successfully implemented in the cancer and HIV settings to identify the optimal dose in a cost-effective way. Specifically, we describe the continual reassessment method (CRM), an adaptive design proposed for cancer trials to reconcile the needs of dose-finding experiments with the ethical demands of established medical practice. We are applying adaptive designs for identifying the optimal dose of medications for the first time in the context of pharmacotherapy research in alcoholism. We provide an example of a topiramate trial as an illustration of how adaptive designs can be used to locate the optimal dose in alcohol treatment trials. It is believed that the introduction of adaptive design methods will enable the development of medications for the treatment of alcohol dependence to be accelerated.
abstractGer	In alcohol dependence studies, the treatment effect at different dose levels remains to be ascertained. Establishing this effect would aid us in identifying the best dose that has satisfactory efficacy while minimizing the rate of adverse events. We advocate the use of dose-finding methodology that has been successfully implemented in the cancer and HIV settings to identify the optimal dose in a cost-effective way. Specifically, we describe the continual reassessment method (CRM), an adaptive design proposed for cancer trials to reconcile the needs of dose-finding experiments with the ethical demands of established medical practice. We are applying adaptive designs for identifying the optimal dose of medications for the first time in the context of pharmacotherapy research in alcoholism. We provide an example of a topiramate trial as an illustration of how adaptive designs can be used to locate the optimal dose in alcohol treatment trials. It is believed that the introduction of adaptive design methods will enable the development of medications for the treatment of alcohol dependence to be accelerated.
abstract_unstemmed	In alcohol dependence studies, the treatment effect at different dose levels remains to be ascertained. Establishing this effect would aid us in identifying the best dose that has satisfactory efficacy while minimizing the rate of adverse events. We advocate the use of dose-finding methodology that has been successfully implemented in the cancer and HIV settings to identify the optimal dose in a cost-effective way. Specifically, we describe the continual reassessment method (CRM), an adaptive design proposed for cancer trials to reconcile the needs of dose-finding experiments with the ethical demands of established medical practice. We are applying adaptive designs for identifying the optimal dose of medications for the first time in the context of pharmacotherapy research in alcoholism. We provide an example of a topiramate trial as an illustration of how adaptive designs can be used to locate the optimal dose in alcohol treatment trials. It is believed that the introduction of adaptive design methods will enable the development of medications for the treatment of alcohol dependence to be accelerated.
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title_short	Obtaining the Optimal Dose in Alcohol Dependence Studies
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Obtaining the Optimal Dose in Alcohol Dependence Studies

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Zugang & Verfügbarkeit

Vorhandene Bände

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