Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland
Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO...
Ausführliche Beschreibung
Autor*in: |
Dong Sheng [verfasserIn] Yan Zhang [verfasserIn] Tian Xue [verfasserIn] Xiao-Yan Zhou [verfasserIn] Xiao-Qiu Li [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: Diagnostic Pathology - BMC, 2005, 17(2022), 1, Seite 8 |
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Übergeordnetes Werk: |
volume:17 ; year:2022 ; number:1 ; pages:8 |
Links: |
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DOI / URN: |
10.1186/s13000-022-01192-w |
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Katalog-ID: |
DOAJ034587942 |
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520 | |a Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. | ||
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10.1186/s13000-022-01192-w doi (DE-627)DOAJ034587942 (DE-599)DOAJ34cdd710beb84e9ba1d9045953d2ab5d DE-627 ger DE-627 rakwb eng RB1-214 Dong Sheng verfasserin aut Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. Acinic cell carcinoma Secretory carcinoma Salivary gland LMO2 Pathology Yan Zhang verfasserin aut Tian Xue verfasserin aut Xiao-Yan Zhou verfasserin aut Xiao-Qiu Li verfasserin aut In Diagnostic Pathology BMC, 2005 17(2022), 1, Seite 8 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:17 year:2022 number:1 pages:8 https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/article/34cdd710beb84e9ba1d9045953d2ab5d kostenfrei https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 8 |
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10.1186/s13000-022-01192-w doi (DE-627)DOAJ034587942 (DE-599)DOAJ34cdd710beb84e9ba1d9045953d2ab5d DE-627 ger DE-627 rakwb eng RB1-214 Dong Sheng verfasserin aut Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. Acinic cell carcinoma Secretory carcinoma Salivary gland LMO2 Pathology Yan Zhang verfasserin aut Tian Xue verfasserin aut Xiao-Yan Zhou verfasserin aut Xiao-Qiu Li verfasserin aut In Diagnostic Pathology BMC, 2005 17(2022), 1, Seite 8 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:17 year:2022 number:1 pages:8 https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/article/34cdd710beb84e9ba1d9045953d2ab5d kostenfrei https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 8 |
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10.1186/s13000-022-01192-w doi (DE-627)DOAJ034587942 (DE-599)DOAJ34cdd710beb84e9ba1d9045953d2ab5d DE-627 ger DE-627 rakwb eng RB1-214 Dong Sheng verfasserin aut Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. Acinic cell carcinoma Secretory carcinoma Salivary gland LMO2 Pathology Yan Zhang verfasserin aut Tian Xue verfasserin aut Xiao-Yan Zhou verfasserin aut Xiao-Qiu Li verfasserin aut In Diagnostic Pathology BMC, 2005 17(2022), 1, Seite 8 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:17 year:2022 number:1 pages:8 https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/article/34cdd710beb84e9ba1d9045953d2ab5d kostenfrei https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 8 |
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10.1186/s13000-022-01192-w doi (DE-627)DOAJ034587942 (DE-599)DOAJ34cdd710beb84e9ba1d9045953d2ab5d DE-627 ger DE-627 rakwb eng RB1-214 Dong Sheng verfasserin aut Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. Acinic cell carcinoma Secretory carcinoma Salivary gland LMO2 Pathology Yan Zhang verfasserin aut Tian Xue verfasserin aut Xiao-Yan Zhou verfasserin aut Xiao-Qiu Li verfasserin aut In Diagnostic Pathology BMC, 2005 17(2022), 1, Seite 8 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:17 year:2022 number:1 pages:8 https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/article/34cdd710beb84e9ba1d9045953d2ab5d kostenfrei https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 8 |
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10.1186/s13000-022-01192-w doi (DE-627)DOAJ034587942 (DE-599)DOAJ34cdd710beb84e9ba1d9045953d2ab5d DE-627 ger DE-627 rakwb eng RB1-214 Dong Sheng verfasserin aut Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. Acinic cell carcinoma Secretory carcinoma Salivary gland LMO2 Pathology Yan Zhang verfasserin aut Tian Xue verfasserin aut Xiao-Yan Zhou verfasserin aut Xiao-Qiu Li verfasserin aut In Diagnostic Pathology BMC, 2005 17(2022), 1, Seite 8 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:17 year:2022 number:1 pages:8 https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/article/34cdd710beb84e9ba1d9045953d2ab5d kostenfrei https://doi.org/10.1186/s13000-022-01192-w kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2022 1 8 |
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Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland |
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Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. |
abstractGer |
Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. |
abstract_unstemmed |
Abstract Background The distinction between acinic cell carcinoma (ACC) and secretory carcinoma (SC) of the salivary gland is hampered by the lack of specific diagnostic markers. It is known the cytoplasm of glandular cells in the salivary gland immunohistochemically expresses LIM Domain Only 2 (LMO2). Herein, we aim to evaluate the expression status of LMO2 in a large cohort of tumors of the salivary gland, with an emphasis on its significance in the distinction of ACC and SC. Methods Immunohistochemical stains were performed to evaluate the expression of LMO2 in normal tissues and tumors of salivary gland. Results LMO2 was expressed in normal serous acinar cells of the salivary gland. We also found the cytoplasmic immunostaining of LMO2 was specific and sensitive for the recognition of ACCs including those with morphological overlaps with SCs, whereas the cytoplasmic expression of LMO2 was not detected in SCs. Conclusions LMO2 is useful for the recognition of ACC and is of potential value in distinguishing ACC from SC. |
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Identification of LMO2 as a new marker for acinic cell carcinoma of salivary gland |
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