Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome
Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACO...
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| Autor*in: |
Jisoo Park, M.D. [verfasserIn] Eun-Kyung Kim, M.D., Ph.D. [verfasserIn] Mi-Ae Kim, M.D., Ph.D. [verfasserIn] Tae-Hyung Kim, M.D., Ph.D. [verfasserIn] Jung Hyun Chang, M.D., Ph.D. [verfasserIn] Yon Ju Ryu, M.D., Ph.D. [verfasserIn] Sei Won Lee, M.D., Ph.D. [verfasserIn] Yeon-Mok Oh, M.D., Ph.D. [verfasserIn] Suk Joong Yong, M.D., Ph.D. [verfasserIn] Won-Il Choi, M.D., Ph.D. [verfasserIn] Kwang Ha Yoo, M.D., Ph.D. [verfasserIn] Ji-Hyun Lee, M.D., Ph.D. [verfasserIn] |
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E-Artikel |
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Englisch |
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2018 |
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In: Tuberculosis and Respiratory Diseases - The Korean Academy of Tuberculosis and Respiratory Diseases, 2018, 81(2018), 4, Seite 289-298 |
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| Übergeordnetes Werk: |
volume:81 ; year:2018 ; number:4 ; pages:289-298 |
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DOAJ034949976 |
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| 520 | |a Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. | ||
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| 700 | 0 | |a Tae-Hyung Kim, M.D., Ph.D. |e verfasserin |4 aut | |
| 700 | 0 | |a Jung Hyun Chang, M.D., Ph.D. |e verfasserin |4 aut | |
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(DE-627)DOAJ034949976 (DE-599)DOAJe274ff0988734fd99e5431d9a9ab688a DE-627 ger DE-627 rakwb eng RC705-779 Jisoo Park, M.D. verfasserin aut Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. asthma pulmonary disease chronic obstructive phenotype Diseases of the respiratory system Eun-Kyung Kim, M.D., Ph.D. verfasserin aut Mi-Ae Kim, M.D., Ph.D. verfasserin aut Tae-Hyung Kim, M.D., Ph.D. verfasserin aut Jung Hyun Chang, M.D., Ph.D. verfasserin aut Yon Ju Ryu, M.D., Ph.D. verfasserin aut Sei Won Lee, M.D., Ph.D. verfasserin aut Yeon-Mok Oh, M.D., Ph.D. verfasserin aut Suk Joong Yong, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Kwang Ha Yoo, M.D., Ph.D. verfasserin aut Ji-Hyun Lee, M.D., Ph.D. verfasserin aut In Tuberculosis and Respiratory Diseases The Korean Academy of Tuberculosis and Respiratory Diseases, 2018 81(2018), 4, Seite 289-298 (DE-627)1760599808 20056184 nnns volume:81 year:2018 number:4 pages:289-298 https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a kostenfrei https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL kostenfrei https://doaj.org/toc/1738-3536 Journal toc kostenfrei https://doaj.org/toc/2005-6184 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 81 2018 4 289-298 |
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(DE-627)DOAJ034949976 (DE-599)DOAJe274ff0988734fd99e5431d9a9ab688a DE-627 ger DE-627 rakwb eng RC705-779 Jisoo Park, M.D. verfasserin aut Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. asthma pulmonary disease chronic obstructive phenotype Diseases of the respiratory system Eun-Kyung Kim, M.D., Ph.D. verfasserin aut Mi-Ae Kim, M.D., Ph.D. verfasserin aut Tae-Hyung Kim, M.D., Ph.D. verfasserin aut Jung Hyun Chang, M.D., Ph.D. verfasserin aut Yon Ju Ryu, M.D., Ph.D. verfasserin aut Sei Won Lee, M.D., Ph.D. verfasserin aut Yeon-Mok Oh, M.D., Ph.D. verfasserin aut Suk Joong Yong, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Kwang Ha Yoo, M.D., Ph.D. verfasserin aut Ji-Hyun Lee, M.D., Ph.D. verfasserin aut In Tuberculosis and Respiratory Diseases The Korean Academy of Tuberculosis and Respiratory Diseases, 2018 81(2018), 4, Seite 289-298 (DE-627)1760599808 20056184 nnns volume:81 year:2018 number:4 pages:289-298 https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a kostenfrei https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL kostenfrei https://doaj.org/toc/1738-3536 Journal toc kostenfrei https://doaj.org/toc/2005-6184 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 81 2018 4 289-298 |
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(DE-627)DOAJ034949976 (DE-599)DOAJe274ff0988734fd99e5431d9a9ab688a DE-627 ger DE-627 rakwb eng RC705-779 Jisoo Park, M.D. verfasserin aut Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. asthma pulmonary disease chronic obstructive phenotype Diseases of the respiratory system Eun-Kyung Kim, M.D., Ph.D. verfasserin aut Mi-Ae Kim, M.D., Ph.D. verfasserin aut Tae-Hyung Kim, M.D., Ph.D. verfasserin aut Jung Hyun Chang, M.D., Ph.D. verfasserin aut Yon Ju Ryu, M.D., Ph.D. verfasserin aut Sei Won Lee, M.D., Ph.D. verfasserin aut Yeon-Mok Oh, M.D., Ph.D. verfasserin aut Suk Joong Yong, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Kwang Ha Yoo, M.D., Ph.D. verfasserin aut Ji-Hyun Lee, M.D., Ph.D. verfasserin aut In Tuberculosis and Respiratory Diseases The Korean Academy of Tuberculosis and Respiratory Diseases, 2018 81(2018), 4, Seite 289-298 (DE-627)1760599808 20056184 nnns volume:81 year:2018 number:4 pages:289-298 https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a kostenfrei https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL kostenfrei https://doaj.org/toc/1738-3536 Journal toc kostenfrei https://doaj.org/toc/2005-6184 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 81 2018 4 289-298 |
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(DE-627)DOAJ034949976 (DE-599)DOAJe274ff0988734fd99e5431d9a9ab688a DE-627 ger DE-627 rakwb eng RC705-779 Jisoo Park, M.D. verfasserin aut Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. asthma pulmonary disease chronic obstructive phenotype Diseases of the respiratory system Eun-Kyung Kim, M.D., Ph.D. verfasserin aut Mi-Ae Kim, M.D., Ph.D. verfasserin aut Tae-Hyung Kim, M.D., Ph.D. verfasserin aut Jung Hyun Chang, M.D., Ph.D. verfasserin aut Yon Ju Ryu, M.D., Ph.D. verfasserin aut Sei Won Lee, M.D., Ph.D. verfasserin aut Yeon-Mok Oh, M.D., Ph.D. verfasserin aut Suk Joong Yong, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Kwang Ha Yoo, M.D., Ph.D. verfasserin aut Ji-Hyun Lee, M.D., Ph.D. verfasserin aut In Tuberculosis and Respiratory Diseases The Korean Academy of Tuberculosis and Respiratory Diseases, 2018 81(2018), 4, Seite 289-298 (DE-627)1760599808 20056184 nnns volume:81 year:2018 number:4 pages:289-298 https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a kostenfrei https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL kostenfrei https://doaj.org/toc/1738-3536 Journal toc kostenfrei https://doaj.org/toc/2005-6184 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 81 2018 4 289-298 |
| allfieldsSound |
(DE-627)DOAJ034949976 (DE-599)DOAJe274ff0988734fd99e5431d9a9ab688a DE-627 ger DE-627 rakwb eng RC705-779 Jisoo Park, M.D. verfasserin aut Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. asthma pulmonary disease chronic obstructive phenotype Diseases of the respiratory system Eun-Kyung Kim, M.D., Ph.D. verfasserin aut Mi-Ae Kim, M.D., Ph.D. verfasserin aut Tae-Hyung Kim, M.D., Ph.D. verfasserin aut Jung Hyun Chang, M.D., Ph.D. verfasserin aut Yon Ju Ryu, M.D., Ph.D. verfasserin aut Sei Won Lee, M.D., Ph.D. verfasserin aut Yeon-Mok Oh, M.D., Ph.D. verfasserin aut Suk Joong Yong, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Won-Il Choi, M.D., Ph.D. verfasserin aut Kwang Ha Yoo, M.D., Ph.D. verfasserin aut Ji-Hyun Lee, M.D., Ph.D. verfasserin aut In Tuberculosis and Respiratory Diseases The Korean Academy of Tuberculosis and Respiratory Diseases, 2018 81(2018), 4, Seite 289-298 (DE-627)1760599808 20056184 nnns volume:81 year:2018 number:4 pages:289-298 https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a kostenfrei https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL kostenfrei https://doaj.org/toc/1738-3536 Journal toc kostenfrei https://doaj.org/toc/2005-6184 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 81 2018 4 289-298 |
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ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. 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Jisoo Park, M.D. |
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RC705-779 Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome asthma pulmonary disease chronic obstructive phenotype |
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Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
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Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
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Jisoo Park, M.D. Eun-Kyung Kim, M.D., Ph.D. Mi-Ae Kim, M.D., Ph.D. Tae-Hyung Kim, M.D., Ph.D. Jung Hyun Chang, M.D., Ph.D. Yon Ju Ryu, M.D., Ph.D. Sei Won Lee, M.D., Ph.D. Yeon-Mok Oh, M.D., Ph.D. Suk Joong Yong, M.D., Ph.D. Won-Il Choi, M.D., Ph.D. Kwang Ha Yoo, M.D., Ph.D. Ji-Hyun Lee, M.D., Ph.D. |
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Jisoo Park, M.D. |
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increased risk of exacerbation in asthma predominant asthma–chronic obstructive pulmonary disease overlap syndrome |
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RC705-779 |
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Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
| abstract |
Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. |
| abstractGer |
Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. |
| abstract_unstemmed |
Background Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. Methods A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled. These patients were divided into asthma-ACOS and COPD-ACOS according to their physician's diagnosis and smoking history of 10 pack-years. Within-group comparisons were made for asthma-ACOS versus COPD-ACOS and light smokers versus heavy smokers. Results Compared to patients with COPD-ACOS, patients with asthma-ACOS experienced exacerbation more often despite their younger age, history of light smoking, and better lung function. While the light-smoking group showed better lung function, they made unscheduled outpatient clinic visits more frequently. On multivariate analysis, asthma-ACOS and poor inhaler compliance were significantly associated with more than two unscheduled clinic visits during the previous year. Conclusion Spirometrically defined ACOS includes heterogeneous subgroups with different clinical features. Phenotyping of ACOS by physician's diagnosis could be significant in predicting future risk of exacerbation. |
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Increased Risk of Exacerbation in Asthma Predominant Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome |
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https://doaj.org/article/e274ff0988734fd99e5431d9a9ab688a https://e-trd.org/search.php?where=aview&id=10.4046/trd.2017.0064&code=0003TRD&vmode=FULL https://doaj.org/toc/1738-3536 https://doaj.org/toc/2005-6184 |
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Eun-Kyung Kim, M.D., Ph.D. Mi-Ae Kim, M.D., Ph.D. Tae-Hyung Kim, M.D., Ph.D. Jung Hyun Chang, M.D., Ph.D. Yon Ju Ryu, M.D., Ph.D. Sei Won Lee, M.D., Ph.D. Yeon-Mok Oh, M.D., Ph.D. Suk Joong Yong, M.D., Ph.D. Won-Il Choi, M.D., Ph.D. Kwang Ha Yoo, M.D., Ph.D. Ji-Hyun Lee, M.D., Ph.D. |
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Eun-Kyung Kim, M.D., Ph.D. Mi-Ae Kim, M.D., Ph.D. Tae-Hyung Kim, M.D., Ph.D. Jung Hyun Chang, M.D., Ph.D. Yon Ju Ryu, M.D., Ph.D. Sei Won Lee, M.D., Ph.D. Yeon-Mok Oh, M.D., Ph.D. Suk Joong Yong, M.D., Ph.D. Won-Il Choi, M.D., Ph.D. Kwang Ha Yoo, M.D., Ph.D. Ji-Hyun Lee, M.D., Ph.D. |
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