Cross-cell DNA methylation annotation and analysis for pan-cancer study

Pan-cancer study can uncover cell- and tissue-specific genomic loci and regions with underlying biological functions, as one of fundamental procedures toward precision medicine. We utilized the online curated resource of DNA methylation annotation knowledgebase, to implement the cross-cell interroga...
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Gespeichert in:

Autor*in:	Binhua Tang [verfasserIn] Weiliang Zhu [verfasserIn] Changping Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	DNA methylation Pan-cancer

Übergeordnetes Werk:	In: Bangladesh Journal of Pharmacology - Bangladesh Pharmacological Society, 2016, 11(2016), S1
Übergeordnetes Werk:	volume:11 ; year:2016 ; number:S1

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ034959815

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callnumber-first	R - Medicine
author	Binhua Tang
spellingShingle	Binhua Tang misc RM1-950 misc DNA methylation misc Pan-cancer misc Therapeutics. Pharmacology Cross-cell DNA methylation annotation and analysis for pan-cancer study
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topic_title	RM1-950 Cross-cell DNA methylation annotation and analysis for pan-cancer study DNA methylation Pan-cancer
topic	misc RM1-950 misc DNA methylation misc Pan-cancer misc Therapeutics. Pharmacology
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title	Cross-cell DNA methylation annotation and analysis for pan-cancer study
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title_full	Cross-cell DNA methylation annotation and analysis for pan-cancer study
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title_sort	cross-cell dna methylation annotation and analysis for pan-cancer study
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title_auth	Cross-cell DNA methylation annotation and analysis for pan-cancer study
abstract	Pan-cancer study can uncover cell- and tissue-specific genomic loci and regions with underlying biological functions, as one of fundamental procedures toward precision medicine. We utilized the online curated resource of DNA methylation annotation knowledgebase, to implement the cross-cell interrogation of pan-cancer study of breast cancer. The study revealed genome-wide differentially-methylated loci and regions by the reduced representation bisulfite sequencing profiling. The knowledgebase contains three level of curated information across multiple cancer and normal cells from the ENCODE Consortium. The reference base covers all identified differentially-methylation CpG sites and regions of interest, further annotated gene information, together with tumor suppressor gene and methylation level. Lastly, it includes the inferred functional association network and related Gene Ontology analysis results based on all the tumor suppressor genes identified from the differentially-methylated regions of interest. Our knowledgebase and analysis results provide a thorough reference source for biomedical researchers and clinicians. The cross-cell analysis results are deposited at: http://github.com/gladex/DMAK.
abstractGer	Pan-cancer study can uncover cell- and tissue-specific genomic loci and regions with underlying biological functions, as one of fundamental procedures toward precision medicine. We utilized the online curated resource of DNA methylation annotation knowledgebase, to implement the cross-cell interrogation of pan-cancer study of breast cancer. The study revealed genome-wide differentially-methylated loci and regions by the reduced representation bisulfite sequencing profiling. The knowledgebase contains three level of curated information across multiple cancer and normal cells from the ENCODE Consortium. The reference base covers all identified differentially-methylation CpG sites and regions of interest, further annotated gene information, together with tumor suppressor gene and methylation level. Lastly, it includes the inferred functional association network and related Gene Ontology analysis results based on all the tumor suppressor genes identified from the differentially-methylated regions of interest. Our knowledgebase and analysis results provide a thorough reference source for biomedical researchers and clinicians. The cross-cell analysis results are deposited at: http://github.com/gladex/DMAK.
abstract_unstemmed	Pan-cancer study can uncover cell- and tissue-specific genomic loci and regions with underlying biological functions, as one of fundamental procedures toward precision medicine. We utilized the online curated resource of DNA methylation annotation knowledgebase, to implement the cross-cell interrogation of pan-cancer study of breast cancer. The study revealed genome-wide differentially-methylated loci and regions by the reduced representation bisulfite sequencing profiling. The knowledgebase contains three level of curated information across multiple cancer and normal cells from the ENCODE Consortium. The reference base covers all identified differentially-methylation CpG sites and regions of interest, further annotated gene information, together with tumor suppressor gene and methylation level. Lastly, it includes the inferred functional association network and related Gene Ontology analysis results based on all the tumor suppressor genes identified from the differentially-methylated regions of interest. Our knowledgebase and analysis results provide a thorough reference source for biomedical researchers and clinicians. The cross-cell analysis results are deposited at: http://github.com/gladex/DMAK.
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title_short	Cross-cell DNA methylation annotation and analysis for pan-cancer study
url	https://doaj.org/article/2057bcbe5f4c442390ede539893215e4 https://www.banglajol.info/index.php/BJP/article/view/26851 https://doaj.org/toc/1991-0088
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