Relationship of neurite architecture to brain activity during task-based fMRI

Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast...
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Autor*in:	Christin Schifani [verfasserIn] Colin Hawco [verfasserIn] Arash Nazeri [verfasserIn] Aristotle N. Voineskos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Gray matter microstructure diffusion-weighted MRI NODDI functional activity task-related fMRI

Übergeordnetes Werk:	In: NeuroImage - Elsevier, 2020, 262(2022), Seite 119575-
Übergeordnetes Werk:	volume:262 ; year:2022 ; pages:119575-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.neuroimage.2022.119575

Katalog-ID:	DOAJ035011386

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allfieldsGer	10.1016/j.neuroimage.2022.119575 doi (DE-627)DOAJ035011386 (DE-599)DOAJ683f173e3eda4ea2b567c42c1e852401 DE-627 ger DE-627 rakwb eng RC321-571 Christin Schifani verfasserin aut Relationship of neurite architecture to brain activity during task-based fMRI 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation. Gray matter microstructure diffusion-weighted MRI NODDI functional activity task-related fMRI Neurosciences. Biological psychiatry. Neuropsychiatry Colin Hawco verfasserin aut Arash Nazeri verfasserin aut Aristotle N. Voineskos verfasserin aut In NeuroImage Elsevier, 2020 262(2022), Seite 119575- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:262 year:2022 pages:119575- https://doi.org/10.1016/j.neuroimage.2022.119575 kostenfrei https://doaj.org/article/683f173e3eda4ea2b567c42c1e852401 kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811922006905 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 262 2022 119575-
allfieldsSound	10.1016/j.neuroimage.2022.119575 doi (DE-627)DOAJ035011386 (DE-599)DOAJ683f173e3eda4ea2b567c42c1e852401 DE-627 ger DE-627 rakwb eng RC321-571 Christin Schifani verfasserin aut Relationship of neurite architecture to brain activity during task-based fMRI 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation. Gray matter microstructure diffusion-weighted MRI NODDI functional activity task-related fMRI Neurosciences. Biological psychiatry. Neuropsychiatry Colin Hawco verfasserin aut Arash Nazeri verfasserin aut Aristotle N. Voineskos verfasserin aut In NeuroImage Elsevier, 2020 262(2022), Seite 119575- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:262 year:2022 pages:119575- https://doi.org/10.1016/j.neuroimage.2022.119575 kostenfrei https://doaj.org/article/683f173e3eda4ea2b567c42c1e852401 kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811922006905 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 262 2022 119575-
language	English
source	In NeuroImage 262(2022), Seite 119575- volume:262 year:2022 pages:119575-
sourceStr	In NeuroImage 262(2022), Seite 119575- volume:262 year:2022 pages:119575-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Gray matter microstructure diffusion-weighted MRI NODDI functional activity task-related fMRI Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	NeuroImage
authorswithroles_txt_mv	Christin Schifani @@aut@@ Colin Hawco @@aut@@ Arash Nazeri @@aut@@ Aristotle N. Voineskos @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	268125503
id	DOAJ035011386
language_de	englisch
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callnumber-first	R - Medicine
author	Christin Schifani
spellingShingle	Christin Schifani misc RC321-571 misc Gray matter microstructure misc diffusion-weighted MRI misc NODDI misc functional activity misc task-related fMRI misc Neurosciences. Biological psychiatry. Neuropsychiatry Relationship of neurite architecture to brain activity during task-based fMRI
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topic_title	RC321-571 Relationship of neurite architecture to brain activity during task-based fMRI Gray matter microstructure diffusion-weighted MRI NODDI functional activity task-related fMRI
topic	misc RC321-571 misc Gray matter microstructure misc diffusion-weighted MRI misc NODDI misc functional activity misc task-related fMRI misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Gray matter microstructure misc diffusion-weighted MRI misc NODDI misc functional activity misc task-related fMRI misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Gray matter microstructure misc diffusion-weighted MRI misc NODDI misc functional activity misc task-related fMRI misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Relationship of neurite architecture to brain activity during task-based fMRI
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title_full	Relationship of neurite architecture to brain activity during task-based fMRI
author_sort	Christin Schifani
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author_browse	Christin Schifani Colin Hawco Arash Nazeri Aristotle N. Voineskos
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title_sort	relationship of neurite architecture to brain activity during task-based fmri
callnumber	RC321-571
title_auth	Relationship of neurite architecture to brain activity during task-based fMRI
abstract	Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation.
abstractGer	Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation.
abstract_unstemmed	Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation.
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title_short	Relationship of neurite architecture to brain activity during task-based fMRI
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Relationship of neurite architecture to brain activity during task-based fMRI

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