Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species

Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of s...
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Autor*in:	Zhong Peng [verfasserIn] Wan Liang [verfasserIn] Fei Wang [verfasserIn] Zhuofei Xu [verfasserIn] Zhihao Xie [verfasserIn] Zhenghan Lian [verfasserIn] Lin Hua [verfasserIn] Rui Zhou [verfasserIn] Huanchun Chen [verfasserIn] Bin Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny

Übergeordnetes Werk:	In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmicb.2018.01408

Katalog-ID:	DOAJ035038349

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allfields	10.3389/fmicb.2018.01408 doi (DE-627)DOAJ035038349 (DE-599)DOAJ17070ddc2a8e41db86d0b9ceb6c46a14 DE-627 ger DE-627 rakwb eng QR1-502 Zhong Peng verfasserin aut Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny. Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology Zhong Peng verfasserin aut Zhong Peng verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Zhuofei Xu verfasserin aut Zhuofei Xu verfasserin aut Zhihao Xie verfasserin aut Zhenghan Lian verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 9(2018) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:9 year:2018 https://doi.org/10.3389/fmicb.2018.01408 kostenfrei https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
spelling	10.3389/fmicb.2018.01408 doi (DE-627)DOAJ035038349 (DE-599)DOAJ17070ddc2a8e41db86d0b9ceb6c46a14 DE-627 ger DE-627 rakwb eng QR1-502 Zhong Peng verfasserin aut Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny. Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology Zhong Peng verfasserin aut Zhong Peng verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Zhuofei Xu verfasserin aut Zhuofei Xu verfasserin aut Zhihao Xie verfasserin aut Zhenghan Lian verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 9(2018) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:9 year:2018 https://doi.org/10.3389/fmicb.2018.01408 kostenfrei https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfields_unstemmed	10.3389/fmicb.2018.01408 doi (DE-627)DOAJ035038349 (DE-599)DOAJ17070ddc2a8e41db86d0b9ceb6c46a14 DE-627 ger DE-627 rakwb eng QR1-502 Zhong Peng verfasserin aut Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny. Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology Zhong Peng verfasserin aut Zhong Peng verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Zhuofei Xu verfasserin aut Zhuofei Xu verfasserin aut Zhihao Xie verfasserin aut Zhenghan Lian verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 9(2018) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:9 year:2018 https://doi.org/10.3389/fmicb.2018.01408 kostenfrei https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsGer	10.3389/fmicb.2018.01408 doi (DE-627)DOAJ035038349 (DE-599)DOAJ17070ddc2a8e41db86d0b9ceb6c46a14 DE-627 ger DE-627 rakwb eng QR1-502 Zhong Peng verfasserin aut Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny. Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology Zhong Peng verfasserin aut Zhong Peng verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Zhuofei Xu verfasserin aut Zhuofei Xu verfasserin aut Zhihao Xie verfasserin aut Zhenghan Lian verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 9(2018) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:9 year:2018 https://doi.org/10.3389/fmicb.2018.01408 kostenfrei https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsSound	10.3389/fmicb.2018.01408 doi (DE-627)DOAJ035038349 (DE-599)DOAJ17070ddc2a8e41db86d0b9ceb6c46a14 DE-627 ger DE-627 rakwb eng QR1-502 Zhong Peng verfasserin aut Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny. Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology Zhong Peng verfasserin aut Zhong Peng verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Wan Liang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Fei Wang verfasserin aut Zhuofei Xu verfasserin aut Zhuofei Xu verfasserin aut Zhihao Xie verfasserin aut Zhenghan Lian verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Lin Hua verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Rui Zhou verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Huanchun Chen verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut Bin Wu verfasserin aut In Frontiers in Microbiology Frontiers Media S.A., 2011 9(2018) (DE-627)642889384 (DE-600)2587354-4 1664302X nnns volume:9 year:2018 https://doi.org/10.3389/fmicb.2018.01408 kostenfrei https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 kostenfrei https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full kostenfrei https://doaj.org/toc/1664-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
language	English
source	In Frontiers in Microbiology 9(2018) volume:9 year:2018
sourceStr	In Frontiers in Microbiology 9(2018) volume:9 year:2018
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny Microbiology
isfreeaccess_bool	true
container_title	Frontiers in Microbiology
authorswithroles_txt_mv	Zhong Peng @@aut@@ Wan Liang @@aut@@ Fei Wang @@aut@@ Zhuofei Xu @@aut@@ Zhihao Xie @@aut@@ Zhenghan Lian @@aut@@ Lin Hua @@aut@@ Rui Zhou @@aut@@ Huanchun Chen @@aut@@ Bin Wu @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	642889384
id	DOAJ035038349
language_de	englisch
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callnumber-first	Q - Science
author	Zhong Peng
spellingShingle	Zhong Peng misc QR1-502 misc Pasteurella multocida misc different host species misc genetic characteristics misc comparative genomics analysis misc phylogeny misc Microbiology Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species
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topic_title	QR1-502 Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species Pasteurella multocida different host species genetic characteristics comparative genomics analysis phylogeny
topic	misc QR1-502 misc Pasteurella multocida misc different host species misc genetic characteristics misc comparative genomics analysis misc phylogeny misc Microbiology
topic_unstemmed	misc QR1-502 misc Pasteurella multocida misc different host species misc genetic characteristics misc comparative genomics analysis misc phylogeny misc Microbiology
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title	Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species
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title_full	Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species
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author_browse	Zhong Peng Wan Liang Fei Wang Zhuofei Xu Zhihao Xie Zhenghan Lian Lin Hua Rui Zhou Huanchun Chen Bin Wu
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title_sort	genetic and phylogenetic characteristics of pasteurella multocida isolates from different host species
callnumber	QR1-502
title_auth	Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species
abstract	Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny.
abstractGer	Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny.
abstract_unstemmed	Pasteurella multocida is a leading cause of respiratory diseases in many host species. To understand the genetic characteristics of P. multocida strains isolated from different host species, we sequenced the genomic DNA of P. multocida isolated from pigs and analyzed the genetic characteristics of strains from avian species, bovine species, pigs, and rabbits using whole genome sequence (WGS) data. Our results found that a capsular: lipopolysaccharide (LPS): multilocus sequence typing (MLST) genotype A: L1: ST129 (43.75%) was predominant in avian P. multocida; while genotypes B: L2: ST122 (60.00%) and A: L3: ST79 (30.00%) were predominate in bovine P. multocida; genotype D: L6: ST50 (37.50%) in porcine P. multocida; and genotype A: L3: ST9 (76.47%) in rabbit P. multocida. Comparative genomic analysis of P. multocida from different host species found that there are no genes in the P. multocida genome that are specific to any type of host. Phylogenetic analysis using either whole-genome single nucleotide polymorphisms (SNPs) or the set of SNPs present in all single-copy core genes across genomes showed that P. multocida strains with the same LPS genotype and MLST genotype were clustered together, suggesting the combining both the LPS and MLST typing schemes better explained the topology seen in the P. multocida phylogeny.
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title_short	Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species
url	https://doi.org/10.3389/fmicb.2018.01408 https://doaj.org/article/17070ddc2a8e41db86d0b9ceb6c46a14 https://www.frontiersin.org/article/10.3389/fmicb.2018.01408/full https://doaj.org/toc/1664-302X
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author2	Zhong Peng Wan Liang Fei Wang Zhuofei Xu Zhihao Xie Zhenghan Lian Lin Hua Rui Zhou Huanchun Chen Bin Wu
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Genetic and Phylogenetic Characteristics of Pasteurella multocida Isolates From Different Host Species

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