Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI
The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 2...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
E. V. Sorokina [verfasserIn] N. K. Akhmatova [verfasserIn] N. B. Egorova [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Журнал микробиологии, эпидемиологии и иммунобиологии - Central Research Institute for Epidemiology, 2020, (2019), 3, Seite 69-76 |
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| Übergeordnetes Werk: |
year:2019 ; number:3 ; pages:69-76 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.36233/0372-9311-2019-3-69-76 |
|---|
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DOAJ035161116 |
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| 520 | |a The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. | ||
| 650 | 4 | |a erythemas | |
| 650 | 4 | |a erythema multiforme | |
| 650 | 4 | |a fixed erythema | |
| 650 | 4 | |a erythema migrans | |
| 650 | 4 | |a erythema annular centrifugal | |
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10.36233/0372-9311-2019-3-69-76 doi (DE-627)DOAJ035161116 (DE-599)DOAJ1ffea6bc34a648f2bed5bf2fd7197124 DE-627 ger DE-627 rakwb rus QR1-502 E. V. Sorokina verfasserin aut Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri Microbiology N. K. Akhmatova verfasserin aut N. B. Egorova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 (2019), 3, Seite 69-76 (DE-627)1760649171 26867613 nnns year:2019 number:3 pages:69-76 https://doi.org/10.36233/0372-9311-2019-3-69-76 kostenfrei https://doaj.org/article/1ffea6bc34a648f2bed5bf2fd7197124 kostenfrei https://microbiol.elpub.ru/jour/article/view/367 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2019 3 69-76 |
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10.36233/0372-9311-2019-3-69-76 doi (DE-627)DOAJ035161116 (DE-599)DOAJ1ffea6bc34a648f2bed5bf2fd7197124 DE-627 ger DE-627 rakwb rus QR1-502 E. V. Sorokina verfasserin aut Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri Microbiology N. K. Akhmatova verfasserin aut N. B. Egorova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 (2019), 3, Seite 69-76 (DE-627)1760649171 26867613 nnns year:2019 number:3 pages:69-76 https://doi.org/10.36233/0372-9311-2019-3-69-76 kostenfrei https://doaj.org/article/1ffea6bc34a648f2bed5bf2fd7197124 kostenfrei https://microbiol.elpub.ru/jour/article/view/367 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2019 3 69-76 |
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10.36233/0372-9311-2019-3-69-76 doi (DE-627)DOAJ035161116 (DE-599)DOAJ1ffea6bc34a648f2bed5bf2fd7197124 DE-627 ger DE-627 rakwb rus QR1-502 E. V. Sorokina verfasserin aut Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri Microbiology N. K. Akhmatova verfasserin aut N. B. Egorova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 (2019), 3, Seite 69-76 (DE-627)1760649171 26867613 nnns year:2019 number:3 pages:69-76 https://doi.org/10.36233/0372-9311-2019-3-69-76 kostenfrei https://doaj.org/article/1ffea6bc34a648f2bed5bf2fd7197124 kostenfrei https://microbiol.elpub.ru/jour/article/view/367 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2019 3 69-76 |
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10.36233/0372-9311-2019-3-69-76 doi (DE-627)DOAJ035161116 (DE-599)DOAJ1ffea6bc34a648f2bed5bf2fd7197124 DE-627 ger DE-627 rakwb rus QR1-502 E. V. Sorokina verfasserin aut Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri Microbiology N. K. Akhmatova verfasserin aut N. B. Egorova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 (2019), 3, Seite 69-76 (DE-627)1760649171 26867613 nnns year:2019 number:3 pages:69-76 https://doi.org/10.36233/0372-9311-2019-3-69-76 kostenfrei https://doaj.org/article/1ffea6bc34a648f2bed5bf2fd7197124 kostenfrei https://microbiol.elpub.ru/jour/article/view/367 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2019 3 69-76 |
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10.36233/0372-9311-2019-3-69-76 doi (DE-627)DOAJ035161116 (DE-599)DOAJ1ffea6bc34a648f2bed5bf2fd7197124 DE-627 ger DE-627 rakwb rus QR1-502 E. V. Sorokina verfasserin aut Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri Microbiology N. K. Akhmatova verfasserin aut N. B. Egorova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 (2019), 3, Seite 69-76 (DE-627)1760649171 26867613 nnns year:2019 number:3 pages:69-76 https://doi.org/10.36233/0372-9311-2019-3-69-76 kostenfrei https://doaj.org/article/1ffea6bc34a648f2bed5bf2fd7197124 kostenfrei https://microbiol.elpub.ru/jour/article/view/367 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR 2019 3 69-76 |
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E. V. Sorokina |
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E. V. Sorokina misc QR1-502 misc erythemas misc erythema multiforme misc fixed erythema misc erythema migrans misc erythema annular centrifugal misc toll-like receptors misc polycomponent vaccine misc mnri misc Microbiology Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI |
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QR1-502 Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI erythemas erythema multiforme fixed erythema erythema migrans erythema annular centrifugal toll-like receptors polycomponent vaccine mnri |
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misc QR1-502 misc erythemas misc erythema multiforme misc fixed erythema misc erythema migrans misc erythema annular centrifugal misc toll-like receptors misc polycomponent vaccine misc mnri misc Microbiology |
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Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI |
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Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI |
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Журнал микробиологии, эпидемиологии и иммунобиологии |
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efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and mnri |
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QR1-502 |
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Efficiency of combined therapy of figuratum and parainfectious erythemas with the use of immunomodulators of different origins and MNRI |
| abstract |
The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. |
| abstractGer |
The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. |
| abstract_unstemmed |
The aim of the study was to study the etiopathogenesis of erythema, comparative study of the clinical efficacy of combination therapy with the use of immunomodulators in erythema, the study of the dynamics of immunological parameters as a result of therapy.Materials and methods. The study included 215 adult patients with erythema. Before treatment and 1.5 months after therapy in patients have been studied: the expression of TLRs on MLPC and skin cells by flow cytometry with the use of the mat for TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9 (Caltag Laboratories, USA) using a flow cytometer FC-500 (Beckman Coulter, USA); the subpopulation composition of peripheral blood lymphocytes; the levels of pro-inflammatory and regulatory cytokines in the serum by the method of solid-phase ELISA using test systems company «Biosource» (Austria); the main classes of immunoglobulins (IgG, IgM, IgA) in serum.Results. It was shown that these pathogenetic and diagnostic significance of viruses of the family nerpesviri-dae, bacterial contamination by different types of microorganisms (Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus spp., Proteus vulgaris). A substance containing antigens of conditionally pathogenic microorganisms, and the use of neuro sensorimotor reflex integration (MNRI) contributed to the decline in the number and severity of recurrences of erythema, the extension of the range expressed Toll-like receptors; increase of lymphocytes with immunophenotype CD3+, CD4+, CD25+, CD95+; increase in IFN-y, decreased IL-4; largely reduced the level of total IgE than other types of therapy.Conclusion. The inclusion in therapy of patients with erythema, immunomodulator of bacterial origin and MNRI promotes increase of clinical efficiency and correlates with the correction of immunological disorders. |
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