Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma

<p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available...
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Autor*in:	Yin Zhengfeng [verfasserIn] Xu Donghui [verfasserIn] Li Bin [verfasserIn] Zhao Yanfang [verfasserIn] Zhou Yanming [verfasserIn] Xie Feng [verfasserIn] Yang Jiamei [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Übergeordnetes Werk:	In: BMC Gastroenterology - BMC, 2003, 10(2010), 1, p 78
Übergeordnetes Werk:	volume:10 ; year:2010 ; number:1, p 78

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-230X-10-78

Katalog-ID:	DOAJ035162058

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p<
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matchkey_str	article:1471230X:2010----::eanlssfaifeunybainesseairscinosal
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publishDate	2010
allfields	10.1186/1471-230X-10-78 doi (DE-627)DOAJ035162058 (DE-599)DOAJ9be97b12d82b4586990da081aa9cd57e DE-627 ger DE-627 rakwb eng RC799-869 Yin Zhengfeng verfasserin aut Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p< Diseases of the digestive system. Gastroenterology Xu Donghui verfasserin aut Li Bin verfasserin aut Zhao Yanfang verfasserin aut Zhou Yanming verfasserin aut Xie Feng verfasserin aut Yang Jiamei verfasserin aut In BMC Gastroenterology BMC, 2003 10(2010), 1, p 78 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:10 year:2010 number:1, p 78 https://doi.org/10.1186/1471-230X-10-78 kostenfrei https://doaj.org/article/9be97b12d82b4586990da081aa9cd57e kostenfrei http://www.biomedcentral.com/1471-230X/10/78 kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1, p 78
spelling	10.1186/1471-230X-10-78 doi (DE-627)DOAJ035162058 (DE-599)DOAJ9be97b12d82b4586990da081aa9cd57e DE-627 ger DE-627 rakwb eng RC799-869 Yin Zhengfeng verfasserin aut Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p< Diseases of the digestive system. Gastroenterology Xu Donghui verfasserin aut Li Bin verfasserin aut Zhao Yanfang verfasserin aut Zhou Yanming verfasserin aut Xie Feng verfasserin aut Yang Jiamei verfasserin aut In BMC Gastroenterology BMC, 2003 10(2010), 1, p 78 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:10 year:2010 number:1, p 78 https://doi.org/10.1186/1471-230X-10-78 kostenfrei https://doaj.org/article/9be97b12d82b4586990da081aa9cd57e kostenfrei http://www.biomedcentral.com/1471-230X/10/78 kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1, p 78
allfields_unstemmed	10.1186/1471-230X-10-78 doi (DE-627)DOAJ035162058 (DE-599)DOAJ9be97b12d82b4586990da081aa9cd57e DE-627 ger DE-627 rakwb eng RC799-869 Yin Zhengfeng verfasserin aut Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p< Diseases of the digestive system. Gastroenterology Xu Donghui verfasserin aut Li Bin verfasserin aut Zhao Yanfang verfasserin aut Zhou Yanming verfasserin aut Xie Feng verfasserin aut Yang Jiamei verfasserin aut In BMC Gastroenterology BMC, 2003 10(2010), 1, p 78 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:10 year:2010 number:1, p 78 https://doi.org/10.1186/1471-230X-10-78 kostenfrei https://doaj.org/article/9be97b12d82b4586990da081aa9cd57e kostenfrei http://www.biomedcentral.com/1471-230X/10/78 kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1, p 78
allfieldsGer	10.1186/1471-230X-10-78 doi (DE-627)DOAJ035162058 (DE-599)DOAJ9be97b12d82b4586990da081aa9cd57e DE-627 ger DE-627 rakwb eng RC799-869 Yin Zhengfeng verfasserin aut Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p< Diseases of the digestive system. Gastroenterology Xu Donghui verfasserin aut Li Bin verfasserin aut Zhao Yanfang verfasserin aut Zhou Yanming verfasserin aut Xie Feng verfasserin aut Yang Jiamei verfasserin aut In BMC Gastroenterology BMC, 2003 10(2010), 1, p 78 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:10 year:2010 number:1, p 78 https://doi.org/10.1186/1471-230X-10-78 kostenfrei https://doaj.org/article/9be97b12d82b4586990da081aa9cd57e kostenfrei http://www.biomedcentral.com/1471-230X/10/78 kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1, p 78
allfieldsSound	10.1186/1471-230X-10-78 doi (DE-627)DOAJ035162058 (DE-599)DOAJ9be97b12d82b4586990da081aa9cd57e DE-627 ger DE-627 rakwb eng RC799-869 Yin Zhengfeng verfasserin aut Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p< Diseases of the digestive system. Gastroenterology Xu Donghui verfasserin aut Li Bin verfasserin aut Zhao Yanfang verfasserin aut Zhou Yanming verfasserin aut Xie Feng verfasserin aut Yang Jiamei verfasserin aut In BMC Gastroenterology BMC, 2003 10(2010), 1, p 78 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:10 year:2010 number:1, p 78 https://doi.org/10.1186/1471-230X-10-78 kostenfrei https://doaj.org/article/9be97b12d82b4586990da081aa9cd57e kostenfrei http://www.biomedcentral.com/1471-230X/10/78 kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2010 1, p 78
language	English
source	In BMC Gastroenterology 10(2010), 1, p 78 volume:10 year:2010 number:1, p 78
sourceStr	In BMC Gastroenterology 10(2010), 1, p 78 volume:10 year:2010 number:1, p 78
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Diseases of the digestive system. Gastroenterology
isfreeaccess_bool	true
container_title	BMC Gastroenterology
authorswithroles_txt_mv	Yin Zhengfeng @@aut@@ Xu Donghui @@aut@@ Li Bin @@aut@@ Zhao Yanfang @@aut@@ Zhou Yanming @@aut@@ Xie Feng @@aut@@ Yang Jiamei @@aut@@
publishDateDaySort_date	2010-01-01T00:00:00Z
hierarchy_top_id	326643702
id	DOAJ035162058
language_de	englisch
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callnumber-first	R - Medicine
author	Yin Zhengfeng
spellingShingle	Yin Zhengfeng misc RC799-869 misc Diseases of the digestive system. Gastroenterology Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
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topic_title	RC799-869 Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
topic	misc RC799-869 misc Diseases of the digestive system. Gastroenterology
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title	Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
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title_full	Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
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author_browse	Yin Zhengfeng Xu Donghui Li Bin Zhao Yanfang Zhou Yanming Xie Feng Yang Jiamei
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format_se	Elektronische Aufsätze
author-letter	Yin Zhengfeng
doi_str_mv	10.1186/1471-230X-10-78
author2-role	verfasserin
title_sort	meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
callnumber	RC799-869
title_auth	Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
abstract	<p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<There is no clear consensus on the better therapy [radiofrequency ablation (RFA) versus hepatic resection (HR)] for small hepatocellular carcinoma (HCC) eligible for surgical treatments. This study is a meta-analysis of the available evidence.</p< <p<Methods</p< <p<Systematic review and meta-analysis of trials comparing RFA with HR for small HCC published from 1997 to 2009 in PubMed and Medline. Pooled odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects model.</p< <p<Results</p< <p<One randomized controlled trial, and 9 nonrandomized controlled trials studies were included in this analysis. These studies included a total of 1411 patients: 744 treated with RFA and 667 treated with HR. The overall survival was significantly higher in patients treated with HR than in those treated with RFA at 3 years (OR: 0.56, 95% CI: 0.44-0.71), and at 5 year (OR: 0.60, 95% CI: 0.36-1.01). RFA has a higher rates of local intrahepatic recurrence compared to HR (OR: 4.50, 95% CI: 2.45-8.27). In the HR group the 1, 3, and 5 years disease -free survival rates were significantly better than in the HR-treated patients (respectively: OR: 0.54, 95% CI: 0.35-0.84; OR: 0.44, 95% CI: 0.28-0.68; OR: 0.64, 95% CI: 0.42-0.99). The postoperative morbidity was higher with HR (OR: 0.29, 95% CI: 0.13-0.65), but no significant differences were found concerning mortality. For tumors ≤ 3 cm HR did not differ significantly from RFA for survival, as reported in three NRCTs .</p< <p<Conclusions</p< <p<HR was superior to RFA in the treatment of patients with small HCC eligible for surgical treatments, particularly for tumors < 3 cm. However, the findings have to be carefully interpreted due to the lower level of evidence.</p<
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title_short	Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma
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