Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.

Gespeichert in:

Autor*in:	Yan Tang [verfasserIn] David J. Kwiatkowski [verfasserIn] Elizabeth P. Henske [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 13(2022), 1, Seite 22
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:22

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-022-32673-7

Katalog-ID:	DOAJ035221607

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author	Yan Tang
spellingShingle	Yan Tang misc Science misc Q Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
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topic_title	Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
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title	Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
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title_full	Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
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title_sort	midkine expression by stem-like tumor cells drives persistence to mtor inhibition and an immune-suppressive microenvironment
title_auth	Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
abstract	The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.
abstractGer	The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.
abstract_unstemmed	The tumour microenvironment in mTORC1 hyperactive cancers remains poorly characterised. Here, integrative analysis in tuberous sclerosis complex tumours with mTORC1 hyperactivity suggests distinct cell states associated with rapamycin resistance and immune modulation.
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title_short	Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
url	https://doi.org/10.1038/s41467-022-32673-7 https://doaj.org/article/c7618ced00e3494296ba20b027e046e6 https://doaj.org/toc/2041-1723
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