PKM2, function and expression and regulation

Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the dee...
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Autor*in:	Ze Zhang [verfasserIn] Xinyue Deng [verfasserIn] Yuanda Liu [verfasserIn] Yahui Liu [verfasserIn] Liankun Sun [verfasserIn] Fangfang Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Cancer metabolism Glycolysis Pyruvate kinase Warburg effect

Übergeordnetes Werk:	In: Cell & Bioscience - BMC, 2011, 9(2019), 1, Seite 25
Übergeordnetes Werk:	volume:9 ; year:2019 ; number:1 ; pages:25

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13578-019-0317-8

Katalog-ID:	DOAJ035398175

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520			\|a Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points.
650		4	\|a Cancer metabolism
650		4	\|a Glycolysis
650		4	\|a Pyruvate kinase
650		4	\|a Warburg effect
653		0	\|a Biotechnology
653		0	\|a Biology (General)
653		0	\|a Biochemistry
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700	0		\|a Liankun Sun \|e verfasserin \|4 aut
700	0		\|a Fangfang Chen \|e verfasserin \|4 aut
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allfields	10.1186/s13578-019-0317-8 doi (DE-627)DOAJ035398175 (DE-599)DOAJ5583e1415c8c4bd1821d38a1e2291232 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Ze Zhang verfasserin aut PKM2, function and expression and regulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points. Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry Xinyue Deng verfasserin aut Yuanda Liu verfasserin aut Yahui Liu verfasserin aut Liankun Sun verfasserin aut Fangfang Chen verfasserin aut In Cell & Bioscience BMC, 2011 9(2019), 1, Seite 25 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:9 year:2019 number:1 pages:25 https://doi.org/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 kostenfrei http://link.springer.com/article/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 1 25
spelling	10.1186/s13578-019-0317-8 doi (DE-627)DOAJ035398175 (DE-599)DOAJ5583e1415c8c4bd1821d38a1e2291232 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Ze Zhang verfasserin aut PKM2, function and expression and regulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points. Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry Xinyue Deng verfasserin aut Yuanda Liu verfasserin aut Yahui Liu verfasserin aut Liankun Sun verfasserin aut Fangfang Chen verfasserin aut In Cell & Bioscience BMC, 2011 9(2019), 1, Seite 25 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:9 year:2019 number:1 pages:25 https://doi.org/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 kostenfrei http://link.springer.com/article/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 1 25
allfields_unstemmed	10.1186/s13578-019-0317-8 doi (DE-627)DOAJ035398175 (DE-599)DOAJ5583e1415c8c4bd1821d38a1e2291232 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Ze Zhang verfasserin aut PKM2, function and expression and regulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points. Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry Xinyue Deng verfasserin aut Yuanda Liu verfasserin aut Yahui Liu verfasserin aut Liankun Sun verfasserin aut Fangfang Chen verfasserin aut In Cell & Bioscience BMC, 2011 9(2019), 1, Seite 25 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:9 year:2019 number:1 pages:25 https://doi.org/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 kostenfrei http://link.springer.com/article/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 1 25
allfieldsGer	10.1186/s13578-019-0317-8 doi (DE-627)DOAJ035398175 (DE-599)DOAJ5583e1415c8c4bd1821d38a1e2291232 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Ze Zhang verfasserin aut PKM2, function and expression and regulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points. Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry Xinyue Deng verfasserin aut Yuanda Liu verfasserin aut Yahui Liu verfasserin aut Liankun Sun verfasserin aut Fangfang Chen verfasserin aut In Cell & Bioscience BMC, 2011 9(2019), 1, Seite 25 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:9 year:2019 number:1 pages:25 https://doi.org/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 kostenfrei http://link.springer.com/article/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 1 25
allfieldsSound	10.1186/s13578-019-0317-8 doi (DE-627)DOAJ035398175 (DE-599)DOAJ5583e1415c8c4bd1821d38a1e2291232 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Ze Zhang verfasserin aut PKM2, function and expression and regulation 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points. Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry Xinyue Deng verfasserin aut Yuanda Liu verfasserin aut Yahui Liu verfasserin aut Liankun Sun verfasserin aut Fangfang Chen verfasserin aut In Cell & Bioscience BMC, 2011 9(2019), 1, Seite 25 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:9 year:2019 number:1 pages:25 https://doi.org/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 kostenfrei http://link.springer.com/article/10.1186/s13578-019-0317-8 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 1 25
language	English
source	In Cell & Bioscience 9(2019), 1, Seite 25 volume:9 year:2019 number:1 pages:25
sourceStr	In Cell & Bioscience 9(2019), 1, Seite 25 volume:9 year:2019 number:1 pages:25
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cancer metabolism Glycolysis Pyruvate kinase Warburg effect Biotechnology Biology (General) Biochemistry
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container_title	Cell & Bioscience
authorswithroles_txt_mv	Ze Zhang @@aut@@ Xinyue Deng @@aut@@ Yuanda Liu @@aut@@ Yahui Liu @@aut@@ Liankun Sun @@aut@@ Fangfang Chen @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
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callnumber-first	T - Technology
author	Ze Zhang
spellingShingle	Ze Zhang misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc Cancer metabolism misc Glycolysis misc Pyruvate kinase misc Warburg effect misc Biotechnology misc Biology (General) misc Biochemistry PKM2, function and expression and regulation
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topic_title	TP248.13-248.65 QH301-705.5 QD415-436 PKM2, function and expression and regulation Cancer metabolism Glycolysis Pyruvate kinase Warburg effect
topic	misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc Cancer metabolism misc Glycolysis misc Pyruvate kinase misc Warburg effect misc Biotechnology misc Biology (General) misc Biochemistry
topic_unstemmed	misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc Cancer metabolism misc Glycolysis misc Pyruvate kinase misc Warburg effect misc Biotechnology misc Biology (General) misc Biochemistry
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title	PKM2, function and expression and regulation
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title_full	PKM2, function and expression and regulation
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title_sort	pkm2, function and expression and regulation
callnumber	TP248.13-248.65
title_auth	PKM2, function and expression and regulation
abstract	Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points.
abstractGer	Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points.
abstract_unstemmed	Abstract Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has received increasing attention. PKM2 can be aggregated into tetrameric and dimeric forms, PKM2 in the dimer state can enter the nuclear to regulate gene expression, the transformation between them can play an important role in tumor cell energy supply, epithelial–mesenchymal transition (EMT), invasion and metastasis and cell proliferation. We will use the switching effect of PKM2 in glucose metabolism as the entry point to expand and enrich the Warburg effect. In addition, PKM2 can also regulate each other with various proteins by phosphorylation, acetylation and other modifications, mediate the different intracellular localization of PKM2 and then exert specific biological functions. In this paper, we will illustrate each of these points.
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title_short	PKM2, function and expression and regulation
url	https://doi.org/10.1186/s13578-019-0317-8 https://doaj.org/article/5583e1415c8c4bd1821d38a1e2291232 http://link.springer.com/article/10.1186/s13578-019-0317-8 https://doaj.org/toc/2045-3701
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doi_str	10.1186/s13578-019-0317-8
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up_date	2024-07-03T14:43:50.175Z
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