Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules
Objective(s): The aim of this study was to determine the important molecules involved in apoptosopium in Jurkat opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecul...
Full description
| Author: |
Mohammad Kazemi Arababadi [VerfasserIn] Gholamreza Asadikaram [VerfasserIn] |
|---|
| Format: |
Electronic Article |
|---|---|
| Language: |
English |
| Published: |
2016 |
|---|
| Subjects: |
|---|
| Containing Work: |
In: Iranian Journal of Basic Medical Sciences - Mashhad University of Medical Sciences, 2009, 19(2016), 2, Seite 215-220 |
|---|---|
| Containing Work: |
volume:19 ; year:2016 ; number:2 ; pages:215-220 |
| Links: |
https://doaj.org/article/f03743e6f2b64feb88c6b7cbab70fe14 [Kostenfrei] http://ijbms.mums.ac.ir/article_6548_d86a2aff9940d220b1630eac8b0f50a6.pdf [Kostenfrei] Journal toc [Kostenfrei] Journal toc [Kostenfrei] |
|---|
| Catalog id: |
DOAJ03558274X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ03558274X | ||
| 003 | DE-627 | ||
| 005 | 20210211131827.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200520s2016 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)DOAJ03558274X | ||
| 035 | |a (DE-599)DOAJf03743e6f2b64feb88c6b7cbab70fe14 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a Mohammad Kazemi Arababadi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Opium induces apoptosis in Jurkat cells via promotion of pro-apoptotic and inhibition of anti-apoptotic molecules |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Objective(s): The aim of this study was to determine the important molecules involved in apoptosopium in Jurkat opium in Jurkat cell line. Materials and Methods: Jurkat cells were incubated 48 hrs with2.86×10-5 g/ml concentration of opium and apoptosis as well as expression levels of related molecules weremeasured. Results: Our results demonstrated that 50.3±0.2 percent of opium treated Jurkat cells were revealed apoptotic features. The levels of mRNA of several pro-apoptotic and anti-apoptotic molecules were increased and decreased, respectively, in the opium treated cells. The results also demonstrated that expression levels of BCL2, DFFA and NOL3 as anti-apoptotic molecules were increased in the opium treated cells. Conclusion: It seems that opium induces apoptosis in Jurkat cells via both intrinsic and extrinsic pathways. Although opium induces apoptosis in the cells but increased expression of some anti-apoptotic molecules may be a normal resistance of the cell for death. | ||
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Jurkat cells | |
| 650 | 4 | |a PCR array | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 700 | 0 | |a Gholamreza Asadikaram |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Iranian Journal of Basic Medical Sciences |d Mashhad University of Medical Sciences, 2009 |g 19(2016), 2, Seite 215-220 |w (DE-627)DOAJ00006212X |x 20083874 |7 |||s |
| 773 | 1 | 8 | |g volume:19 |g year:2016 |g number:2 |g pages:215-220 |
| 856 | 4 | 0 | |u https://doaj.org/article/f03743e6f2b64feb88c6b7cbab70fe14 |z Kostenfrei |
| 856 | 4 | 0 | |u http://ijbms.mums.ac.ir/article_6548_d86a2aff9940d220b1630eac8b0f50a6.pdf |z Kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2008-3866 |y Journal toc |z Kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2008-3874 |y Journal toc |z Kostenfrei |
| 912 | |a GBV_DOAJ | ||
| 936 | u | w | |d 19 |j 2016 |e 2 |h 215-220 |
| 951 | |a AR | ||
| 952 | |d 19 |j 2016 |e 2 |h 215-220 | ||