Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with you...
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Autor*in:	Se-Ran Jun [verfasserIn] Amrita Cheema [verfasserIn] Chhanda Bose [verfasserIn] Marjan Boerma [verfasserIn] Philip T. Palade [verfasserIn] Eugenia Carvalho [verfasserIn] Sanjay Awasthi [verfasserIn] Sharda P. Singh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	aging sulforaphane gut microbiome metabolome biomarkers

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 8(2020), 10, p 1500
Übergeordnetes Werk:	volume:8 ; year:2020 ; number:10, p 1500

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms8101500

Katalog-ID:	DOAJ035656395

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spelling	10.3390/microorganisms8101500 doi (DE-627)DOAJ035656395 (DE-599)DOAJ05088a60266f4873bccc338f353f7b0b DE-627 ger DE-627 rakwb eng QH301-705.5 Se-Ran Jun verfasserin aut Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6–8 weeks) and old (21–22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, <i<Oscillospira</i<, <i<Ruminococcus</i<, and <i<Allobaculum</i<. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging. aging sulforaphane gut microbiome metabolome biomarkers Biology (General) Amrita Cheema verfasserin aut Chhanda Bose verfasserin aut Marjan Boerma verfasserin aut Philip T. Palade verfasserin aut Eugenia Carvalho verfasserin aut Sanjay Awasthi verfasserin aut Sharda P. Singh verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1500 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1500 https://doi.org/10.3390/microorganisms8101500 kostenfrei https://doaj.org/article/05088a60266f4873bccc338f353f7b0b kostenfrei https://www.mdpi.com/2076-2607/8/10/1500 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1500
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allfieldsSound	10.3390/microorganisms8101500 doi (DE-627)DOAJ035656395 (DE-599)DOAJ05088a60266f4873bccc338f353f7b0b DE-627 ger DE-627 rakwb eng QH301-705.5 Se-Ran Jun verfasserin aut Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6–8 weeks) and old (21–22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, <i<Oscillospira</i<, <i<Ruminococcus</i<, and <i<Allobaculum</i<. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging. aging sulforaphane gut microbiome metabolome biomarkers Biology (General) Amrita Cheema verfasserin aut Chhanda Bose verfasserin aut Marjan Boerma verfasserin aut Philip T. Palade verfasserin aut Eugenia Carvalho verfasserin aut Sanjay Awasthi verfasserin aut Sharda P. Singh verfasserin aut In Microorganisms MDPI AG, 2013 8(2020), 10, p 1500 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:8 year:2020 number:10, p 1500 https://doi.org/10.3390/microorganisms8101500 kostenfrei https://doaj.org/article/05088a60266f4873bccc338f353f7b0b kostenfrei https://www.mdpi.com/2076-2607/8/10/1500 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2020 10, p 1500
language	English
source	In Microorganisms 8(2020), 10, p 1500 volume:8 year:2020 number:10, p 1500
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authorswithroles_txt_mv	Se-Ran Jun @@aut@@ Amrita Cheema @@aut@@ Chhanda Bose @@aut@@ Marjan Boerma @@aut@@ Philip T. Palade @@aut@@ Eugenia Carvalho @@aut@@ Sanjay Awasthi @@aut@@ Sharda P. Singh @@aut@@
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callnumber-first	Q - Science
author	Se-Ran Jun
spellingShingle	Se-Ran Jun misc QH301-705.5 misc aging misc sulforaphane misc gut microbiome misc metabolome misc biomarkers misc Biology (General) Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
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topic_title	QH301-705.5 Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice aging sulforaphane gut microbiome metabolome biomarkers
topic	misc QH301-705.5 misc aging misc sulforaphane misc gut microbiome misc metabolome misc biomarkers misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc aging misc sulforaphane misc gut microbiome misc metabolome misc biomarkers misc Biology (General)
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title	Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
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title_full	Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
author_sort	Se-Ran Jun
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author_browse	Se-Ran Jun Amrita Cheema Chhanda Bose Marjan Boerma Philip T. Palade Eugenia Carvalho Sanjay Awasthi Sharda P. Singh
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title_sort	multi-omic analysis reveals different effects of sulforaphane on the microbiome and metabolome in old compared to young mice
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title_auth	Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
abstract	Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6–8 weeks) and old (21–22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, <i<Oscillospira</i<, <i<Ruminococcus</i<, and <i<Allobaculum</i<. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging.
abstractGer	Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6–8 weeks) and old (21–22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, <i<Oscillospira</i<, <i<Ruminococcus</i<, and <i<Allobaculum</i<. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging.
abstract_unstemmed	Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut microbiome and metabolome in old mouse model compared with young mice. Young (6–8 weeks) and old (21–22 months) male C57BL/6J mice were provided regular rodent chow ± SFN for 2 months. We collected fecal samples before and after SFN administration and profiled the microbiome and metabolome. Multi-omics datasets were analyzed individually and integrated to investigate the relationship between SFN diet, the gut microbiome, and metabolome. The SFN diet restored the gut microbiome in old mice to mimic that in young mice, enriching bacteria known to be associated with an improved intestinal barrier function and the production of anti-inflammatory compounds. The tricarboxylic acid cycle decreased and amino acid metabolism-related pathways increased. Integration of multi-omic datasets revealed SFN diet-induced metabolite biomarkers in old mice associated principally with the genera, <i<Oscillospira</i<, <i<Ruminococcus</i<, and <i<Allobaculum</i<. Collectively, our results support a hypothesis that SFN diet exerts anti-aging effects in part by influencing the gut microbiome and metabolome. Modulating the gut microbiome by SFN may have the potential to promote healthier aging.
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title_short	Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
url	https://doi.org/10.3390/microorganisms8101500 https://doaj.org/article/05088a60266f4873bccc338f353f7b0b https://www.mdpi.com/2076-2607/8/10/1500 https://doaj.org/toc/2076-2607
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author2	Amrita Cheema Chhanda Bose Marjan Boerma Philip T. Palade Eugenia Carvalho Sanjay Awasthi Sharda P. Singh
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Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice

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