Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study

Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study wa...
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Autor*in:	Sivasankari Thirunavukarasu [verfasserIn] Philips Mathew [verfasserIn] Ravi David Austin [verfasserIn] Kumar Chandan Srivastava [verfasserIn] S Ramasamy [verfasserIn] V Usha [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue

Übergeordnetes Werk:	In: Journal of Indian Academy of Oral Medicine and Radiology - Wolters Kluwer Medknow Publications, 2017, 32(2020), 3, Seite 253-258
Übergeordnetes Werk:	volume:32 ; year:2020 ; number:3 ; pages:253-258

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.4103/jiaomr.jiaomr_22_20

Katalog-ID:	DOAJ035700157

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245	1	0	\|a Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
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520			\|a Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low.
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653		0	\|a Medical physics. Medical radiology. Nuclear medicine
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700	0		\|a V Usha \|e verfasserin \|4 aut
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allfields	10.4103/jiaomr.jiaomr_22_20 doi (DE-627)DOAJ035700157 (DE-599)DOAJ0498ed0fa02148779a85f89106478a96 DE-627 ger DE-627 rakwb eng RK1-715 R895-920 Sivasankari Thirunavukarasu verfasserin aut Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low. lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue Dentistry Medical physics. Medical radiology. Nuclear medicine Philips Mathew verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut S Ramasamy verfasserin aut V Usha verfasserin aut In Journal of Indian Academy of Oral Medicine and Radiology Wolters Kluwer Medknow Publications, 2017 32(2020), 3, Seite 253-258 (DE-627)1034695436 09751572 nnns volume:32 year:2020 number:3 pages:253-258 https://doi.org/10.4103/jiaomr.jiaomr_22_20 kostenfrei https://doaj.org/article/0498ed0fa02148779a85f89106478a96 kostenfrei http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu kostenfrei https://doaj.org/toc/0972-1363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2020 3 253-258
spelling	10.4103/jiaomr.jiaomr_22_20 doi (DE-627)DOAJ035700157 (DE-599)DOAJ0498ed0fa02148779a85f89106478a96 DE-627 ger DE-627 rakwb eng RK1-715 R895-920 Sivasankari Thirunavukarasu verfasserin aut Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low. lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue Dentistry Medical physics. Medical radiology. Nuclear medicine Philips Mathew verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut S Ramasamy verfasserin aut V Usha verfasserin aut In Journal of Indian Academy of Oral Medicine and Radiology Wolters Kluwer Medknow Publications, 2017 32(2020), 3, Seite 253-258 (DE-627)1034695436 09751572 nnns volume:32 year:2020 number:3 pages:253-258 https://doi.org/10.4103/jiaomr.jiaomr_22_20 kostenfrei https://doaj.org/article/0498ed0fa02148779a85f89106478a96 kostenfrei http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu kostenfrei https://doaj.org/toc/0972-1363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2020 3 253-258
allfields_unstemmed	10.4103/jiaomr.jiaomr_22_20 doi (DE-627)DOAJ035700157 (DE-599)DOAJ0498ed0fa02148779a85f89106478a96 DE-627 ger DE-627 rakwb eng RK1-715 R895-920 Sivasankari Thirunavukarasu verfasserin aut Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low. lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue Dentistry Medical physics. Medical radiology. Nuclear medicine Philips Mathew verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut S Ramasamy verfasserin aut V Usha verfasserin aut In Journal of Indian Academy of Oral Medicine and Radiology Wolters Kluwer Medknow Publications, 2017 32(2020), 3, Seite 253-258 (DE-627)1034695436 09751572 nnns volume:32 year:2020 number:3 pages:253-258 https://doi.org/10.4103/jiaomr.jiaomr_22_20 kostenfrei https://doaj.org/article/0498ed0fa02148779a85f89106478a96 kostenfrei http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu kostenfrei https://doaj.org/toc/0972-1363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2020 3 253-258
allfieldsGer	10.4103/jiaomr.jiaomr_22_20 doi (DE-627)DOAJ035700157 (DE-599)DOAJ0498ed0fa02148779a85f89106478a96 DE-627 ger DE-627 rakwb eng RK1-715 R895-920 Sivasankari Thirunavukarasu verfasserin aut Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low. lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue Dentistry Medical physics. Medical radiology. Nuclear medicine Philips Mathew verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut S Ramasamy verfasserin aut V Usha verfasserin aut In Journal of Indian Academy of Oral Medicine and Radiology Wolters Kluwer Medknow Publications, 2017 32(2020), 3, Seite 253-258 (DE-627)1034695436 09751572 nnns volume:32 year:2020 number:3 pages:253-258 https://doi.org/10.4103/jiaomr.jiaomr_22_20 kostenfrei https://doaj.org/article/0498ed0fa02148779a85f89106478a96 kostenfrei http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu kostenfrei https://doaj.org/toc/0972-1363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2020 3 253-258
allfieldsSound	10.4103/jiaomr.jiaomr_22_20 doi (DE-627)DOAJ035700157 (DE-599)DOAJ0498ed0fa02148779a85f89106478a96 DE-627 ger DE-627 rakwb eng RK1-715 R895-920 Sivasankari Thirunavukarasu verfasserin aut Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low. lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue Dentistry Medical physics. Medical radiology. Nuclear medicine Philips Mathew verfasserin aut Ravi David Austin verfasserin aut Kumar Chandan Srivastava verfasserin aut S Ramasamy verfasserin aut V Usha verfasserin aut In Journal of Indian Academy of Oral Medicine and Radiology Wolters Kluwer Medknow Publications, 2017 32(2020), 3, Seite 253-258 (DE-627)1034695436 09751572 nnns volume:32 year:2020 number:3 pages:253-258 https://doi.org/10.4103/jiaomr.jiaomr_22_20 kostenfrei https://doaj.org/article/0498ed0fa02148779a85f89106478a96 kostenfrei http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu kostenfrei https://doaj.org/toc/0972-1363 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 32 2020 3 253-258
language	English
source	In Journal of Indian Academy of Oral Medicine and Radiology 32(2020), 3, Seite 253-258 volume:32 year:2020 number:3 pages:253-258
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callnumber-first	R - Medicine
author	Sivasankari Thirunavukarasu
spellingShingle	Sivasankari Thirunavukarasu misc RK1-715 misc R895-920 misc lugols iodine misc oral leukoplakia misc oral lichen planus misc sensitivity and specificity misc toluidine blue misc Dentistry misc Medical physics. Medical radiology. Nuclear medicine Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
authorStr	Sivasankari Thirunavukarasu
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topic_title	RK1-715 R895-920 Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study lugols iodine oral leukoplakia oral lichen planus sensitivity and specificity toluidine blue
topic	misc RK1-715 misc R895-920 misc lugols iodine misc oral leukoplakia misc oral lichen planus misc sensitivity and specificity misc toluidine blue misc Dentistry misc Medical physics. Medical radiology. Nuclear medicine
topic_unstemmed	misc RK1-715 misc R895-920 misc lugols iodine misc oral leukoplakia misc oral lichen planus misc sensitivity and specificity misc toluidine blue misc Dentistry misc Medical physics. Medical radiology. Nuclear medicine
topic_browse	misc RK1-715 misc R895-920 misc lugols iodine misc oral leukoplakia misc oral lichen planus misc sensitivity and specificity misc toluidine blue misc Dentistry misc Medical physics. Medical radiology. Nuclear medicine
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title	Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
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title_full	Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
author_sort	Sivasankari Thirunavukarasu
journal	Journal of Indian Academy of Oral Medicine and Radiology
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author_browse	Sivasankari Thirunavukarasu Philips Mathew Ravi David Austin Kumar Chandan Srivastava S Ramasamy V Usha
container_volume	32
class	RK1-715 R895-920
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author-letter	Sivasankari Thirunavukarasu
doi_str_mv	10.4103/jiaomr.jiaomr_22_20
author2-role	verfasserin
title_sort	efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of leukoplakia and erosive lichen planus – a cross-sectional study
callnumber	RK1-715
title_auth	Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
abstract	Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low.
abstractGer	Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low.
abstract_unstemmed	Background and Objectives: Early detection and treatment of oral cancer will significantly improve the survival rate and prognosis of the patients. Adjunctive diagnostic aids such as vital staining have been developed to supplement clinical examination and improve the diagnosis. The current study was conducted to evaluate the diagnostic efficacy of acetic acid (2%) (AA), lugol's iodine (3% dilution) (LIS), and toluidine blue (1%) (TBS) in oral leukoplakia (OL) and erosive variant of oral lichen planus (OLP). Materials and Methods: A hospital-based, cross-sectional study was conducted with 30 randomly selected subjects having clinically proven cases of OL and erosive OLP. Every patient underwent AA, LIS, and TBS application to their oral lesions in a sequential manner. Subsequently, clinical and histopathologic diagnosis was compared with staining results of each. Cases which were diagnosed as epithelial hyperplasia were considered as a control group. Data are presented in numbers and percentages. Chi-square test was used to compare between TBS, LIS and AA. Diagnostic efficiency and reliability was calculated by sensitivity and specificity test in terms of its utility in predicting the dysplastic nature of the lesion. Results: Sensitivity of both TBS and LIS staining was calculated as 90.48% whereas the specificity of the former test was 22.22% and latter was 11.11%. AA test showed a sensitivity of 57.14% and specificity of 33.33%. Multiple comparisons of staining with three agents and the histopathologic variants did not show any statistically significant difference. Conclusion: TBS and LIS staining showed high sensitivity in diagnosing OL and erosive OLP compared to AA. The specificity of all three modalities used was low.
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title_short	Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study
url	https://doi.org/10.4103/jiaomr.jiaomr_22_20 https://doaj.org/article/0498ed0fa02148779a85f89106478a96 http://www.jiaomr.in/article.asp?issn=0972-1363;year=2020;volume=32;issue=3;spage=253;epage=258;aulast=Thirunavukarasu https://doaj.org/toc/0972-1363
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author2	Philips Mathew Ravi David Austin Kumar Chandan Srivastava S Ramasamy V Usha
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up_date	2024-07-03T16:30:20.827Z
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Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia and erosive lichen planus – A cross-sectional study

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