Bowel “Dissection” in Microvillus Inclusion Disease

A preterm male neonate was diagnosed as having microvillus inclusion disease based on the characteristics of histological and ultrastructural findings. The peripheral blood sample also revealed MYO5B mutation. He had been on long-term parenteral nutrition. However, a bowel segment was seen in the ba...
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Autor*in:	Ming-Chou Chiang [verfasserIn] Jen-Fu Hsu [verfasserIn] Chuen Hsueh [verfasserIn] Hsun-Chin Chao [verfasserIn] Tzu-Hao Wang [verfasserIn] Chih-Ping Chen [verfasserIn] Ming-Wei Lai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	antenatal intestinal obstruction diarrhea dissection microvillus inclusion disease (MVID)

Übergeordnetes Werk:	In: Pediatrics and Neonatology - Elsevier, 2017, 56(2015), 2, Seite 129-131
Übergeordnetes Werk:	volume:56 ; year:2015 ; number:2 ; pages:129-131

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.pedneo.2013.03.004

Katalog-ID:	DOAJ035796553

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520			\|a A preterm male neonate was diagnosed as having microvillus inclusion disease based on the characteristics of histological and ultrastructural findings. The peripheral blood sample also revealed MYO5B mutation. He had been on long-term parenteral nutrition. However, a bowel segment was seen in the baby's diaper during hospitalization when he was 5 months old. Serial abdominal ultrasound demonstrated progressive dissection of the bowel wall with detached mucosa in real-time. Small intestinal epithelia were seen on the histology of the detached bowel segment. He died 2 weeks after the episode; postmortem autopsy showed diffuse detachment of mucosa of small bowels without perforation. This is the first report of an infant with microvillus inclusion disease that presented with bowel “dissection”. Weakened adhesion and integrity of intestinal epithelial cells caused by MYO5B mutation was speculated to result in the dissection and detachment of the epithelia of the gastrointestinal tract.
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authorswithroles_txt_mv	Ming-Chou Chiang @@aut@@ Jen-Fu Hsu @@aut@@ Chuen Hsueh @@aut@@ Hsun-Chin Chao @@aut@@ Tzu-Hao Wang @@aut@@ Chih-Ping Chen @@aut@@ Ming-Wei Lai @@aut@@
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callnumber-first	R - Medicine
author	Ming-Chou Chiang
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topic	misc RJ1-570 misc antenatal intestinal obstruction misc diarrhea misc dissection misc microvillus inclusion disease (MVID) misc Pediatrics
topic_unstemmed	misc RJ1-570 misc antenatal intestinal obstruction misc diarrhea misc dissection misc microvillus inclusion disease (MVID) misc Pediatrics
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title	Bowel “Dissection” in Microvillus Inclusion Disease
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title_full	Bowel “Dissection” in Microvillus Inclusion Disease
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title_sort	bowel “dissection” in microvillus inclusion disease
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title_auth	Bowel “Dissection” in Microvillus Inclusion Disease
abstract	A preterm male neonate was diagnosed as having microvillus inclusion disease based on the characteristics of histological and ultrastructural findings. The peripheral blood sample also revealed MYO5B mutation. He had been on long-term parenteral nutrition. However, a bowel segment was seen in the baby's diaper during hospitalization when he was 5 months old. Serial abdominal ultrasound demonstrated progressive dissection of the bowel wall with detached mucosa in real-time. Small intestinal epithelia were seen on the histology of the detached bowel segment. He died 2 weeks after the episode; postmortem autopsy showed diffuse detachment of mucosa of small bowels without perforation. This is the first report of an infant with microvillus inclusion disease that presented with bowel “dissection”. Weakened adhesion and integrity of intestinal epithelial cells caused by MYO5B mutation was speculated to result in the dissection and detachment of the epithelia of the gastrointestinal tract.
abstractGer	A preterm male neonate was diagnosed as having microvillus inclusion disease based on the characteristics of histological and ultrastructural findings. The peripheral blood sample also revealed MYO5B mutation. He had been on long-term parenteral nutrition. However, a bowel segment was seen in the baby's diaper during hospitalization when he was 5 months old. Serial abdominal ultrasound demonstrated progressive dissection of the bowel wall with detached mucosa in real-time. Small intestinal epithelia were seen on the histology of the detached bowel segment. He died 2 weeks after the episode; postmortem autopsy showed diffuse detachment of mucosa of small bowels without perforation. This is the first report of an infant with microvillus inclusion disease that presented with bowel “dissection”. Weakened adhesion and integrity of intestinal epithelial cells caused by MYO5B mutation was speculated to result in the dissection and detachment of the epithelia of the gastrointestinal tract.
abstract_unstemmed	A preterm male neonate was diagnosed as having microvillus inclusion disease based on the characteristics of histological and ultrastructural findings. The peripheral blood sample also revealed MYO5B mutation. He had been on long-term parenteral nutrition. However, a bowel segment was seen in the baby's diaper during hospitalization when he was 5 months old. Serial abdominal ultrasound demonstrated progressive dissection of the bowel wall with detached mucosa in real-time. Small intestinal epithelia were seen on the histology of the detached bowel segment. He died 2 weeks after the episode; postmortem autopsy showed diffuse detachment of mucosa of small bowels without perforation. This is the first report of an infant with microvillus inclusion disease that presented with bowel “dissection”. Weakened adhesion and integrity of intestinal epithelial cells caused by MYO5B mutation was speculated to result in the dissection and detachment of the epithelia of the gastrointestinal tract.
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title_short	Bowel “Dissection” in Microvillus Inclusion Disease
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