Genome-wide Survey of Ribosome Collision

Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of pro...
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Autor*in:	Peixun Han [verfasserIn] Yuichi Shichino [verfasserIn] Tilman Schneider-Poetsch [verfasserIn] Mari Mito [verfasserIn] Satoshi Hashimoto [verfasserIn] Tsuyoshi Udagawa [verfasserIn] Kenji Kohno [verfasserIn] Minoru Yoshida [verfasserIn] Yuichiro Mishima [verfasserIn] Toshifumi Inada [verfasserIn] Shintaro Iwasaki [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	translation ribosome ribosome profiling disome disome profiling ribosome collision

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 31(2020), 5, Seite -
Übergeordnetes Werk:	volume:31 ; year:2020 ; number:5 ; pages:-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2020.107610

Katalog-ID:	DOAJ035815140

Internformat


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520			\|a Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes.
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650		4	\|a ribosome collision
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700	0		\|a Tilman Schneider-Poetsch \|e verfasserin \|4 aut
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700	0		\|a Satoshi Hashimoto \|e verfasserin \|4 aut
700	0		\|a Tsuyoshi Udagawa \|e verfasserin \|4 aut
700	0		\|a Kenji Kohno \|e verfasserin \|4 aut
700	0		\|a Minoru Yoshida \|e verfasserin \|4 aut
700	0		\|a Yuichiro Mishima \|e verfasserin \|4 aut
700	0		\|a Toshifumi Inada \|e verfasserin \|4 aut
700	0		\|a Shintaro Iwasaki \|e verfasserin \|4 aut
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Indexfelder

author_variant	p h ph y s ys t s p tsp m m mm s h sh t u tu k k kk m y my y m ym t i ti s i si
matchkey_str	article:22111247:2020----::eoeieuvyfioo
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publishDate	2020
allfields	10.1016/j.celrep.2020.107610 doi (DE-627)DOAJ035815140 (DE-599)DOAJ931f5d3326cc4313b94bc11e5a4171bb DE-627 ger DE-627 rakwb eng QH301-705.5 Peixun Han verfasserin aut Genome-wide Survey of Ribosome Collision 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes. translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General) Yuichi Shichino verfasserin aut Tilman Schneider-Poetsch verfasserin aut Mari Mito verfasserin aut Satoshi Hashimoto verfasserin aut Tsuyoshi Udagawa verfasserin aut Kenji Kohno verfasserin aut Minoru Yoshida verfasserin aut Yuichiro Mishima verfasserin aut Toshifumi Inada verfasserin aut Shintaro Iwasaki verfasserin aut In Cell Reports Elsevier, 2015 31(2020), 5, Seite - (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:31 year:2020 number:5 pages:- https://doi.org/10.1016/j.celrep.2020.107610 kostenfrei https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720305593 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 31 2020 5 -
spelling	10.1016/j.celrep.2020.107610 doi (DE-627)DOAJ035815140 (DE-599)DOAJ931f5d3326cc4313b94bc11e5a4171bb DE-627 ger DE-627 rakwb eng QH301-705.5 Peixun Han verfasserin aut Genome-wide Survey of Ribosome Collision 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes. translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General) Yuichi Shichino verfasserin aut Tilman Schneider-Poetsch verfasserin aut Mari Mito verfasserin aut Satoshi Hashimoto verfasserin aut Tsuyoshi Udagawa verfasserin aut Kenji Kohno verfasserin aut Minoru Yoshida verfasserin aut Yuichiro Mishima verfasserin aut Toshifumi Inada verfasserin aut Shintaro Iwasaki verfasserin aut In Cell Reports Elsevier, 2015 31(2020), 5, Seite - (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:31 year:2020 number:5 pages:- https://doi.org/10.1016/j.celrep.2020.107610 kostenfrei https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720305593 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 31 2020 5 -
allfields_unstemmed	10.1016/j.celrep.2020.107610 doi (DE-627)DOAJ035815140 (DE-599)DOAJ931f5d3326cc4313b94bc11e5a4171bb DE-627 ger DE-627 rakwb eng QH301-705.5 Peixun Han verfasserin aut Genome-wide Survey of Ribosome Collision 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes. translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General) Yuichi Shichino verfasserin aut Tilman Schneider-Poetsch verfasserin aut Mari Mito verfasserin aut Satoshi Hashimoto verfasserin aut Tsuyoshi Udagawa verfasserin aut Kenji Kohno verfasserin aut Minoru Yoshida verfasserin aut Yuichiro Mishima verfasserin aut Toshifumi Inada verfasserin aut Shintaro Iwasaki verfasserin aut In Cell Reports Elsevier, 2015 31(2020), 5, Seite - (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:31 year:2020 number:5 pages:- https://doi.org/10.1016/j.celrep.2020.107610 kostenfrei https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720305593 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 31 2020 5 -
allfieldsGer	10.1016/j.celrep.2020.107610 doi (DE-627)DOAJ035815140 (DE-599)DOAJ931f5d3326cc4313b94bc11e5a4171bb DE-627 ger DE-627 rakwb eng QH301-705.5 Peixun Han verfasserin aut Genome-wide Survey of Ribosome Collision 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes. translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General) Yuichi Shichino verfasserin aut Tilman Schneider-Poetsch verfasserin aut Mari Mito verfasserin aut Satoshi Hashimoto verfasserin aut Tsuyoshi Udagawa verfasserin aut Kenji Kohno verfasserin aut Minoru Yoshida verfasserin aut Yuichiro Mishima verfasserin aut Toshifumi Inada verfasserin aut Shintaro Iwasaki verfasserin aut In Cell Reports Elsevier, 2015 31(2020), 5, Seite - (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:31 year:2020 number:5 pages:- https://doi.org/10.1016/j.celrep.2020.107610 kostenfrei https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720305593 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 31 2020 5 -
allfieldsSound	10.1016/j.celrep.2020.107610 doi (DE-627)DOAJ035815140 (DE-599)DOAJ931f5d3326cc4313b94bc11e5a4171bb DE-627 ger DE-627 rakwb eng QH301-705.5 Peixun Han verfasserin aut Genome-wide Survey of Ribosome Collision 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes. translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General) Yuichi Shichino verfasserin aut Tilman Schneider-Poetsch verfasserin aut Mari Mito verfasserin aut Satoshi Hashimoto verfasserin aut Tsuyoshi Udagawa verfasserin aut Kenji Kohno verfasserin aut Minoru Yoshida verfasserin aut Yuichiro Mishima verfasserin aut Toshifumi Inada verfasserin aut Shintaro Iwasaki verfasserin aut In Cell Reports Elsevier, 2015 31(2020), 5, Seite - (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:31 year:2020 number:5 pages:- https://doi.org/10.1016/j.celrep.2020.107610 kostenfrei https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720305593 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 31 2020 5 -
language	English
source	In Cell Reports 31(2020), 5, Seite - volume:31 year:2020 number:5 pages:-
sourceStr	In Cell Reports 31(2020), 5, Seite - volume:31 year:2020 number:5 pages:-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	translation ribosome ribosome profiling disome disome profiling ribosome collision Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Peixun Han @@aut@@ Yuichi Shichino @@aut@@ Tilman Schneider-Poetsch @@aut@@ Mari Mito @@aut@@ Satoshi Hashimoto @@aut@@ Tsuyoshi Udagawa @@aut@@ Kenji Kohno @@aut@@ Minoru Yoshida @@aut@@ Yuichiro Mishima @@aut@@ Toshifumi Inada @@aut@@ Shintaro Iwasaki @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ035815140
language_de	englisch
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callnumber-first	Q - Science
author	Peixun Han
spellingShingle	Peixun Han misc QH301-705.5 misc translation misc ribosome misc ribosome profiling misc disome misc disome profiling misc ribosome collision misc Biology (General) Genome-wide Survey of Ribosome Collision
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topic_title	QH301-705.5 Genome-wide Survey of Ribosome Collision translation ribosome ribosome profiling disome disome profiling ribosome collision
topic	misc QH301-705.5 misc translation misc ribosome misc ribosome profiling misc disome misc disome profiling misc ribosome collision misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc translation misc ribosome misc ribosome profiling misc disome misc disome profiling misc ribosome collision misc Biology (General)
topic_browse	misc QH301-705.5 misc translation misc ribosome misc ribosome profiling misc disome misc disome profiling misc ribosome collision misc Biology (General)
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title	Genome-wide Survey of Ribosome Collision
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title_full	Genome-wide Survey of Ribosome Collision
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author_browse	Peixun Han Yuichi Shichino Tilman Schneider-Poetsch Mari Mito Satoshi Hashimoto Tsuyoshi Udagawa Kenji Kohno Minoru Yoshida Yuichiro Mishima Toshifumi Inada Shintaro Iwasaki
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author-letter	Peixun Han
doi_str_mv	10.1016/j.celrep.2020.107610
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title_sort	genome-wide survey of ribosome collision
callnumber	QH301-705.5
title_auth	Genome-wide Survey of Ribosome Collision
abstract	Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes.
abstractGer	Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes.
abstract_unstemmed	Summary: Ribosome movement is not always smooth and is rather often impeded. For ribosome pauses, fundamental issues remain to be addressed, including where ribosomes pause on mRNAs, what kind of RNA/amino acid sequence causes this pause, and the physiological significance of this attenuation of protein synthesis. Here, we survey the positions of ribosome collisions caused by ribosome pauses in humans and zebrafish using modified ribosome profiling. Collided ribosomes, i.e., disomes, emerge at various sites: Pro-Pro/Gly/Asp motifs; Arg-X-Lys motifs; stop codons; and 3′ untranslated regions. The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites. In particular, XBP1u, a precursor of endoplasmic reticulum (ER)-stress-responsive transcription factor, shows striking queues of collided ribosomes and thus acts as a degradation substrate by ribosome-associated quality control. Our results provide insight into the causes and consequences of ribosome pause by dissecting collided ribosomes.
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container_issue	5
title_short	Genome-wide Survey of Ribosome Collision
url	https://doi.org/10.1016/j.celrep.2020.107610 https://doaj.org/article/931f5d3326cc4313b94bc11e5a4171bb http://www.sciencedirect.com/science/article/pii/S2211124720305593 https://doaj.org/toc/2211-1247
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author2	Yuichi Shichino Tilman Schneider-Poetsch Mari Mito Satoshi Hashimoto Tsuyoshi Udagawa Kenji Kohno Minoru Yoshida Yuichiro Mishima Toshifumi Inada Shintaro Iwasaki
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up_date	2024-07-03T17:07:40.299Z
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score	7.402236

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