Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study

Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kumar Chandan Srivastava [verfasserIn] Ravi David Austin [verfasserIn] Deepti Shrivastava [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Antioxidants lipid peroxidation oral cancer oxidative stress

Übergeordnetes Werk:	In: Dental Research Journal - Wolters Kluwer Medknow Publications, 2008, 13(2016), 2, Seite 181-187
Übergeordnetes Werk:	volume:13 ; year:2016 ; number:2 ; pages:181-187

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/1735-3327.178210

Katalog-ID:	DOAJ035856653

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520			\|a Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker.
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spelling	10.4103/1735-3327.178210 doi (DE-627)DOAJ035856653 (DE-599)DOAJc3f04f4c9e98435e83ae4a84f4fea732 DE-627 ger DE-627 rakwb eng RK1-715 Kumar Chandan Srivastava verfasserin aut Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker. Antioxidants lipid peroxidation oral cancer oxidative stress Dentistry Ravi David Austin verfasserin aut Deepti Shrivastava verfasserin aut In Dental Research Journal Wolters Kluwer Medknow Publications, 2008 13(2016), 2, Seite 181-187 (DE-627)561316473 (DE-600)2418290-4 20080255 nnns volume:13 year:2016 number:2 pages:181-187 https://doi.org/10.4103/1735-3327.178210 kostenfrei https://doaj.org/article/c3f04f4c9e98435e83ae4a84f4fea732 kostenfrei http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=181;epage=187;aulast=Srivastava kostenfrei https://doaj.org/toc/1735-3327 Journal toc kostenfrei https://doaj.org/toc/2008-0255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 2 181-187
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allfieldsGer	10.4103/1735-3327.178210 doi (DE-627)DOAJ035856653 (DE-599)DOAJc3f04f4c9e98435e83ae4a84f4fea732 DE-627 ger DE-627 rakwb eng RK1-715 Kumar Chandan Srivastava verfasserin aut Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker. Antioxidants lipid peroxidation oral cancer oxidative stress Dentistry Ravi David Austin verfasserin aut Deepti Shrivastava verfasserin aut In Dental Research Journal Wolters Kluwer Medknow Publications, 2008 13(2016), 2, Seite 181-187 (DE-627)561316473 (DE-600)2418290-4 20080255 nnns volume:13 year:2016 number:2 pages:181-187 https://doi.org/10.4103/1735-3327.178210 kostenfrei https://doaj.org/article/c3f04f4c9e98435e83ae4a84f4fea732 kostenfrei http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=181;epage=187;aulast=Srivastava kostenfrei https://doaj.org/toc/1735-3327 Journal toc kostenfrei https://doaj.org/toc/2008-0255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 2 181-187
allfieldsSound	10.4103/1735-3327.178210 doi (DE-627)DOAJ035856653 (DE-599)DOAJc3f04f4c9e98435e83ae4a84f4fea732 DE-627 ger DE-627 rakwb eng RK1-715 Kumar Chandan Srivastava verfasserin aut Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker. Antioxidants lipid peroxidation oral cancer oxidative stress Dentistry Ravi David Austin verfasserin aut Deepti Shrivastava verfasserin aut In Dental Research Journal Wolters Kluwer Medknow Publications, 2008 13(2016), 2, Seite 181-187 (DE-627)561316473 (DE-600)2418290-4 20080255 nnns volume:13 year:2016 number:2 pages:181-187 https://doi.org/10.4103/1735-3327.178210 kostenfrei https://doaj.org/article/c3f04f4c9e98435e83ae4a84f4fea732 kostenfrei http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=181;epage=187;aulast=Srivastava kostenfrei https://doaj.org/toc/1735-3327 Journal toc kostenfrei https://doaj.org/toc/2008-0255 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 2 181-187
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callnumber-first	R - Medicine
author	Kumar Chandan Srivastava
spellingShingle	Kumar Chandan Srivastava misc RK1-715 misc Antioxidants misc lipid peroxidation misc oral cancer misc oxidative stress misc Dentistry Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
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topic_title	RK1-715 Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study Antioxidants lipid peroxidation oral cancer oxidative stress
topic	misc RK1-715 misc Antioxidants misc lipid peroxidation misc oral cancer misc oxidative stress misc Dentistry
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title	Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
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title_full	Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
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author_browse	Kumar Chandan Srivastava Ravi David Austin Deepti Shrivastava
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title_sort	evaluation of oxidant-antioxidant status in tissue samples in oral cancer: a case control study
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title_auth	Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
abstract	Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker.
abstractGer	Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker.
abstract_unstemmed	Background: Imbalances between the oxidant-antioxidant status have been implicated in the pathogenesis of several diseases, including cancer. The aim of this study was to evaluate the extent of lipid peroxidation and antioxidants in the tissue samples of oral squamous cell carcinoma (OSCC) patients of different clinical stages in comparison with the healthy controls. Materials and Methods: A case-control study was designed with 20 new histopathologically proven oral carcinoma patients and an equal number of age, sex, and tobacco chewing habit matched healthy subjects. Their tissue samples were subjected to evaluation of lipid peroxidation product and antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and glutathione peroxidase (GPx) using spectrophotometric methods. The data are expressed as mean ΁ standard deviation. The statistical comparisons between the study groups were performed by independent Student′s unpaired t-test and one-way analysis of variance. Post-hoc analysis was performed for within study group comparisons. Karl Pearson correlation was performed for the biochemical parameters within the group and between the groups. For statistically significant correlations, simple linear regression was performed using SPSS (α=0.05). Results: Significant reduction in lipid peroxidation (P < 0.001) SOD and CAT (P < 0.001) was observed in the tissue of OSCC patients as compared with the healthy controls. On the other hand, reduced GSH and GPx were significantly increased in tumor samples. Conclusion: Reduced lipid peroxidation and increased activity of reduced GSH and GPx provides the suitable environment for the local growth and invasion of the tumor and metastasis in the later stages. Among the antioxidant enzymes, GSH reductase appears to have a profound role in carcinogenesis and thus it can be considered as potential prognostic marker.
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title_short	Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study
url	https://doi.org/10.4103/1735-3327.178210 https://doaj.org/article/c3f04f4c9e98435e83ae4a84f4fea732 http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=2;spage=181;epage=187;aulast=Srivastava https://doaj.org/toc/1735-3327 https://doaj.org/toc/2008-0255
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Evaluation of oxidant-antioxidant status in tissue samples in oral cancer: A case control study

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