Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella

Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expressio...
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Gespeichert in:

Autor*in:	Xiao-Bing Lu [verfasserIn] Zhao-Xi Wang [verfasserIn] Shu-Bo Liu [verfasserIn] Xiang-Yang Zhang [verfasserIn] Long-Feng Lu [verfasserIn] Shun Li [verfasserIn] Dan-Dan Chen [verfasserIn] Pin Nie [verfasserIn] Yong-An Zhang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	CIITA MHC II IRF1 IRF2 IFN-γ grass carp

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2019.01106

Katalog-ID:	DOAJ035893052

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spelling	10.3389/fimmu.2019.01106 doi (DE-627)DOAJ035893052 (DE-599)DOAJ27cf9b0f0e294c18b0fbc975a5284734 DE-627 ger DE-627 rakwb eng RC581-607 Xiao-Bing Lu verfasserin aut Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression. CIITA MHC II IRF1 IRF2 IFN-γ grass carp Immunologic diseases. Allergy Xiao-Bing Lu verfasserin aut Zhao-Xi Wang verfasserin aut Zhao-Xi Wang verfasserin aut Shu-Bo Liu verfasserin aut Shu-Bo Liu verfasserin aut Xiang-Yang Zhang verfasserin aut Xiang-Yang Zhang verfasserin aut Long-Feng Lu verfasserin aut Shun Li verfasserin aut Dan-Dan Chen verfasserin aut Pin Nie verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01106 kostenfrei https://doaj.org/article/27cf9b0f0e294c18b0fbc975a5284734 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01106/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
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allfieldsGer	10.3389/fimmu.2019.01106 doi (DE-627)DOAJ035893052 (DE-599)DOAJ27cf9b0f0e294c18b0fbc975a5284734 DE-627 ger DE-627 rakwb eng RC581-607 Xiao-Bing Lu verfasserin aut Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression. CIITA MHC II IRF1 IRF2 IFN-γ grass carp Immunologic diseases. Allergy Xiao-Bing Lu verfasserin aut Zhao-Xi Wang verfasserin aut Zhao-Xi Wang verfasserin aut Shu-Bo Liu verfasserin aut Shu-Bo Liu verfasserin aut Xiang-Yang Zhang verfasserin aut Xiang-Yang Zhang verfasserin aut Long-Feng Lu verfasserin aut Shun Li verfasserin aut Dan-Dan Chen verfasserin aut Pin Nie verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01106 kostenfrei https://doaj.org/article/27cf9b0f0e294c18b0fbc975a5284734 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01106/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfieldsSound	10.3389/fimmu.2019.01106 doi (DE-627)DOAJ035893052 (DE-599)DOAJ27cf9b0f0e294c18b0fbc975a5284734 DE-627 ger DE-627 rakwb eng RC581-607 Xiao-Bing Lu verfasserin aut Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression. CIITA MHC II IRF1 IRF2 IFN-γ grass carp Immunologic diseases. Allergy Xiao-Bing Lu verfasserin aut Zhao-Xi Wang verfasserin aut Zhao-Xi Wang verfasserin aut Shu-Bo Liu verfasserin aut Shu-Bo Liu verfasserin aut Xiang-Yang Zhang verfasserin aut Xiang-Yang Zhang verfasserin aut Long-Feng Lu verfasserin aut Shun Li verfasserin aut Dan-Dan Chen verfasserin aut Pin Nie verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut Yong-An Zhang verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01106 kostenfrei https://doaj.org/article/27cf9b0f0e294c18b0fbc975a5284734 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01106/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
language	English
source	In Frontiers in Immunology 10(2019) volume:10 year:2019
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topic_facet	CIITA MHC II IRF1 IRF2 IFN-γ grass carp Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
authorswithroles_txt_mv	Xiao-Bing Lu @@aut@@ Zhao-Xi Wang @@aut@@ Shu-Bo Liu @@aut@@ Xiang-Yang Zhang @@aut@@ Long-Feng Lu @@aut@@ Shun Li @@aut@@ Dan-Dan Chen @@aut@@ Pin Nie @@aut@@ Yong-An Zhang @@aut@@
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callnumber-first	R - Medicine
author	Xiao-Bing Lu
spellingShingle	Xiao-Bing Lu misc RC581-607 misc CIITA misc MHC II misc IRF1 misc IRF2 misc IFN-γ misc grass carp misc Immunologic diseases. Allergy Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
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topic_title	RC581-607 Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella CIITA MHC II IRF1 IRF2 IFN-γ grass carp
topic	misc RC581-607 misc CIITA misc MHC II misc IRF1 misc IRF2 misc IFN-γ misc grass carp misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc CIITA misc MHC II misc IRF1 misc IRF2 misc IFN-γ misc grass carp misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc CIITA misc MHC II misc IRF1 misc IRF2 misc IFN-γ misc grass carp misc Immunologic diseases. Allergy
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title	Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
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title_full	Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
author_sort	Xiao-Bing Lu
journal	Frontiers in Immunology
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title_sort	interferon regulatory factors 1 and 2 play different roles in mhc ii expression mediated by ciita in grass carp, ctenopharyngodon idella
callnumber	RC581-607
title_auth	Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
abstract	Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression.
abstractGer	Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression.
abstract_unstemmed	Expression of major histocompatibility complex class II (MHC II) molecules, which determines both the immune repertoire during development and subsequent triggering of immune responses, is always under the control of a unique (MHC class II) transactivator, CIITA. The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. These data suggested that grass carp, compared with mammals, has both conservative and unique mechanisms in the regulation of MHC II expression.
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title_short	Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
url	https://doi.org/10.3389/fimmu.2019.01106 https://doaj.org/article/27cf9b0f0e294c18b0fbc975a5284734 https://www.frontiersin.org/article/10.3389/fimmu.2019.01106/full https://doaj.org/toc/1664-3224
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author2Str	Xiao-Bing Lu Zhao-Xi Wang Shu-Bo Liu Xiang-Yang Zhang Long-Feng Lu Shun Li Dan-Dan Chen Pin Nie Yong-An Zhang
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up_date	2024-07-03T17:33:20.439Z
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The IFN-γ-inducible MHC II expression has been extensively and thoroughly studied in humans, but not in bony fish. In this study, the characterization of CIITA was identified and its functional domains were analyzed in grass carp. The absence of GAS and E-box in the promoter region of grass carp CIITA, might imply that the cooperative interaction between STAT1 and USF1 to active the CIITA expression, found in mammals, is not present in bony fish. After the transfection of IFN-γ or IFN-γ rel, only IFN-γ could induce MHC II expression mediated by CIITA. Moreover, interferon regulatory factor (IRF) 2, which cooperates with IRF1 to active the CIITA promoter IV expression in mammals, played an antagonistic role to IRF1 in the activation of grass carp CIITA. 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Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella

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