The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception

Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a...
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Autor*in:	Valentina E. Bychkova [verfasserIn] Dmitry A. Dolgikh [verfasserIn] Vitalii A. Balobanov [verfasserIn] Alexei V. Finkelstein [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	globular protein rigid native state molten globule intrinsically disordered functional state unfolded state

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 27(2022), 14, p 4361
Übergeordnetes Werk:	volume:27 ; year:2022 ; number:14, p 4361

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules27144361

Katalog-ID:	DOAJ03593140X

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520			\|a Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners.
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spelling	10.3390/molecules27144361 doi (DE-627)DOAJ03593140X (DE-599)DOAJ1ffd028543564bc991959cbd8bfdcbd9 DE-627 ger DE-627 rakwb eng QD241-441 Valentina E. Bychkova verfasserin aut The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners. globular protein rigid native state molten globule intrinsically disordered functional state unfolded state Organic chemistry Dmitry A. Dolgikh verfasserin aut Vitalii A. Balobanov verfasserin aut Alexei V. Finkelstein verfasserin aut In Molecules MDPI AG, 2003 27(2022), 14, p 4361 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:14, p 4361 https://doi.org/10.3390/molecules27144361 kostenfrei https://doaj.org/article/1ffd028543564bc991959cbd8bfdcbd9 kostenfrei https://www.mdpi.com/1420-3049/27/14/4361 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 14, p 4361
allfields_unstemmed	10.3390/molecules27144361 doi (DE-627)DOAJ03593140X (DE-599)DOAJ1ffd028543564bc991959cbd8bfdcbd9 DE-627 ger DE-627 rakwb eng QD241-441 Valentina E. Bychkova verfasserin aut The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners. globular protein rigid native state molten globule intrinsically disordered functional state unfolded state Organic chemistry Dmitry A. Dolgikh verfasserin aut Vitalii A. Balobanov verfasserin aut Alexei V. Finkelstein verfasserin aut In Molecules MDPI AG, 2003 27(2022), 14, p 4361 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:14, p 4361 https://doi.org/10.3390/molecules27144361 kostenfrei https://doaj.org/article/1ffd028543564bc991959cbd8bfdcbd9 kostenfrei https://www.mdpi.com/1420-3049/27/14/4361 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 14, p 4361
allfieldsGer	10.3390/molecules27144361 doi (DE-627)DOAJ03593140X (DE-599)DOAJ1ffd028543564bc991959cbd8bfdcbd9 DE-627 ger DE-627 rakwb eng QD241-441 Valentina E. Bychkova verfasserin aut The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners. globular protein rigid native state molten globule intrinsically disordered functional state unfolded state Organic chemistry Dmitry A. Dolgikh verfasserin aut Vitalii A. Balobanov verfasserin aut Alexei V. Finkelstein verfasserin aut In Molecules MDPI AG, 2003 27(2022), 14, p 4361 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:14, p 4361 https://doi.org/10.3390/molecules27144361 kostenfrei https://doaj.org/article/1ffd028543564bc991959cbd8bfdcbd9 kostenfrei https://www.mdpi.com/1420-3049/27/14/4361 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 14, p 4361
allfieldsSound	10.3390/molecules27144361 doi (DE-627)DOAJ03593140X (DE-599)DOAJ1ffd028543564bc991959cbd8bfdcbd9 DE-627 ger DE-627 rakwb eng QD241-441 Valentina E. Bychkova verfasserin aut The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners. globular protein rigid native state molten globule intrinsically disordered functional state unfolded state Organic chemistry Dmitry A. Dolgikh verfasserin aut Vitalii A. Balobanov verfasserin aut Alexei V. Finkelstein verfasserin aut In Molecules MDPI AG, 2003 27(2022), 14, p 4361 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:27 year:2022 number:14, p 4361 https://doi.org/10.3390/molecules27144361 kostenfrei https://doaj.org/article/1ffd028543564bc991959cbd8bfdcbd9 kostenfrei https://www.mdpi.com/1420-3049/27/14/4361 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 27 2022 14, p 4361
language	English
source	In Molecules 27(2022), 14, p 4361 volume:27 year:2022 number:14, p 4361
sourceStr	In Molecules 27(2022), 14, p 4361 volume:27 year:2022 number:14, p 4361
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	globular protein rigid native state molten globule intrinsically disordered functional state unfolded state Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Valentina E. Bychkova @@aut@@ Dmitry A. Dolgikh @@aut@@ Vitalii A. Balobanov @@aut@@ Alexei V. Finkelstein @@aut@@
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callnumber-first	Q - Science
author	Valentina E. Bychkova
spellingShingle	Valentina E. Bychkova misc QD241-441 misc globular protein misc rigid native state misc molten globule misc intrinsically disordered misc functional state misc unfolded state misc Organic chemistry The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception
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topic_title	QD241-441 The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception globular protein rigid native state molten globule intrinsically disordered functional state unfolded state
topic	misc QD241-441 misc globular protein misc rigid native state misc molten globule misc intrinsically disordered misc functional state misc unfolded state misc Organic chemistry
topic_unstemmed	misc QD241-441 misc globular protein misc rigid native state misc molten globule misc intrinsically disordered misc functional state misc unfolded state misc Organic chemistry
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title	The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception
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title_sort	molten globule state of a globular protein in a cell is more or less frequent case rather than an exception
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title_auth	The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception
abstract	Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners.
abstractGer	Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners.
abstract_unstemmed	Quite a long time ago, Oleg B. Ptitsyn put forward a hypothesis about the possible functional significance of the molten globule (MG) state for the functioning of proteins. MG is an intermediate between the unfolded and the native state of a protein. Its experimental detection and investigation in a cell are extremely difficult. In the last decades, intensive studies have demonstrated that the MG-like state of some globular proteins arises from either their modifications or interactions with protein partners or other cell components. This review summarizes such reports. In many cases, MG was evidenced to be functionally important. Thus, the MG state is quite common for functional cellular proteins. This supports Ptitsyn’s hypothesis that some globular proteins may switch between two active states, rigid (N) and soft (MG), to work in solution or interact with partners.
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title_short	The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception
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The Molten Globule State of a Globular Protein in a Cell Is More or Less Frequent Case Rather than an Exception

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