Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse

One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocanna...
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Autor*in:	Fiorentina Roviezzo [verfasserIn] Antonietta Rossi [verfasserIn] Elisabetta Caiazzo [verfasserIn] Pierangelo Orlando [verfasserIn] Maria A. Riemma [verfasserIn] Valentina M. Iacono [verfasserIn] Andrea Guarino [verfasserIn] Armando Ialenti [verfasserIn] Carla Cicala [verfasserIn] Alessio Peritore [verfasserIn] Raffaele Capasso [verfasserIn] Vincenzo Di Marzo [verfasserIn] Angelo A. Izzo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 8(2017)
Übergeordnetes Werk:	volume:8 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2017.00857

Katalog-ID:	DOAJ035953594

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allfields	10.3389/fphar.2017.00857 doi (DE-627)DOAJ035953594 (DE-599)DOAJ84d8cb0cc2214f2a86ffc0e1706eff38 DE-627 ger DE-627 rakwb eng RM1-950 Fiorentina Roviezzo verfasserin aut Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features. palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology Antonietta Rossi verfasserin aut Elisabetta Caiazzo verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Maria A. Riemma verfasserin aut Valentina M. Iacono verfasserin aut Andrea Guarino verfasserin aut Armando Ialenti verfasserin aut Carla Cicala verfasserin aut Alessio Peritore verfasserin aut Alessio Peritore verfasserin aut Raffaele Capasso verfasserin aut Raffaele Capasso verfasserin aut Vincenzo Di Marzo verfasserin aut Vincenzo Di Marzo verfasserin aut Angelo A. Izzo verfasserin aut Angelo A. Izzo verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 8(2017) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:8 year:2017 https://doi.org/10.3389/fphar.2017.00857 kostenfrei https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 kostenfrei http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
spelling	10.3389/fphar.2017.00857 doi (DE-627)DOAJ035953594 (DE-599)DOAJ84d8cb0cc2214f2a86ffc0e1706eff38 DE-627 ger DE-627 rakwb eng RM1-950 Fiorentina Roviezzo verfasserin aut Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features. palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology Antonietta Rossi verfasserin aut Elisabetta Caiazzo verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Maria A. Riemma verfasserin aut Valentina M. Iacono verfasserin aut Andrea Guarino verfasserin aut Armando Ialenti verfasserin aut Carla Cicala verfasserin aut Alessio Peritore verfasserin aut Alessio Peritore verfasserin aut Raffaele Capasso verfasserin aut Raffaele Capasso verfasserin aut Vincenzo Di Marzo verfasserin aut Vincenzo Di Marzo verfasserin aut Angelo A. Izzo verfasserin aut Angelo A. Izzo verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 8(2017) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:8 year:2017 https://doi.org/10.3389/fphar.2017.00857 kostenfrei https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 kostenfrei http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfields_unstemmed	10.3389/fphar.2017.00857 doi (DE-627)DOAJ035953594 (DE-599)DOAJ84d8cb0cc2214f2a86ffc0e1706eff38 DE-627 ger DE-627 rakwb eng RM1-950 Fiorentina Roviezzo verfasserin aut Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features. palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology Antonietta Rossi verfasserin aut Elisabetta Caiazzo verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Maria A. Riemma verfasserin aut Valentina M. Iacono verfasserin aut Andrea Guarino verfasserin aut Armando Ialenti verfasserin aut Carla Cicala verfasserin aut Alessio Peritore verfasserin aut Alessio Peritore verfasserin aut Raffaele Capasso verfasserin aut Raffaele Capasso verfasserin aut Vincenzo Di Marzo verfasserin aut Vincenzo Di Marzo verfasserin aut Angelo A. Izzo verfasserin aut Angelo A. Izzo verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 8(2017) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:8 year:2017 https://doi.org/10.3389/fphar.2017.00857 kostenfrei https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 kostenfrei http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfieldsGer	10.3389/fphar.2017.00857 doi (DE-627)DOAJ035953594 (DE-599)DOAJ84d8cb0cc2214f2a86ffc0e1706eff38 DE-627 ger DE-627 rakwb eng RM1-950 Fiorentina Roviezzo verfasserin aut Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features. palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology Antonietta Rossi verfasserin aut Elisabetta Caiazzo verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Maria A. Riemma verfasserin aut Valentina M. Iacono verfasserin aut Andrea Guarino verfasserin aut Armando Ialenti verfasserin aut Carla Cicala verfasserin aut Alessio Peritore verfasserin aut Alessio Peritore verfasserin aut Raffaele Capasso verfasserin aut Raffaele Capasso verfasserin aut Vincenzo Di Marzo verfasserin aut Vincenzo Di Marzo verfasserin aut Angelo A. Izzo verfasserin aut Angelo A. Izzo verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 8(2017) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:8 year:2017 https://doi.org/10.3389/fphar.2017.00857 kostenfrei https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 kostenfrei http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
allfieldsSound	10.3389/fphar.2017.00857 doi (DE-627)DOAJ035953594 (DE-599)DOAJ84d8cb0cc2214f2a86ffc0e1706eff38 DE-627 ger DE-627 rakwb eng RM1-950 Fiorentina Roviezzo verfasserin aut Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features. palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology Antonietta Rossi verfasserin aut Elisabetta Caiazzo verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Pierangelo Orlando verfasserin aut Maria A. Riemma verfasserin aut Valentina M. Iacono verfasserin aut Andrea Guarino verfasserin aut Armando Ialenti verfasserin aut Carla Cicala verfasserin aut Alessio Peritore verfasserin aut Alessio Peritore verfasserin aut Raffaele Capasso verfasserin aut Raffaele Capasso verfasserin aut Vincenzo Di Marzo verfasserin aut Vincenzo Di Marzo verfasserin aut Angelo A. Izzo verfasserin aut Angelo A. Izzo verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 8(2017) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:8 year:2017 https://doi.org/10.3389/fphar.2017.00857 kostenfrei https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 kostenfrei http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017
language	English
source	In Frontiers in Pharmacology 8(2017) volume:8 year:2017
sourceStr	In Frontiers in Pharmacology 8(2017) volume:8 year:2017
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Frontiers in Pharmacology
authorswithroles_txt_mv	Fiorentina Roviezzo @@aut@@ Antonietta Rossi @@aut@@ Elisabetta Caiazzo @@aut@@ Pierangelo Orlando @@aut@@ Maria A. Riemma @@aut@@ Valentina M. Iacono @@aut@@ Andrea Guarino @@aut@@ Armando Ialenti @@aut@@ Carla Cicala @@aut@@ Alessio Peritore @@aut@@ Raffaele Capasso @@aut@@ Vincenzo Di Marzo @@aut@@ Angelo A. Izzo @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	642889392
id	DOAJ035953594
language_de	englisch
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callnumber-first	R - Medicine
author	Fiorentina Roviezzo
spellingShingle	Fiorentina Roviezzo misc RM1-950 misc palmitoylethanolamide misc mast cells misc allergen sensitization misc bronchial hyperreactivity misc airway inflammation misc Therapeutics. Pharmacology Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
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topic_title	RM1-950 Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse palmitoylethanolamide mast cells allergen sensitization bronchial hyperreactivity airway inflammation
topic	misc RM1-950 misc palmitoylethanolamide misc mast cells misc allergen sensitization misc bronchial hyperreactivity misc airway inflammation misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc palmitoylethanolamide misc mast cells misc allergen sensitization misc bronchial hyperreactivity misc airway inflammation misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc palmitoylethanolamide misc mast cells misc allergen sensitization misc bronchial hyperreactivity misc airway inflammation misc Therapeutics. Pharmacology
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title	Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
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title_full	Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
author_sort	Fiorentina Roviezzo
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author_browse	Fiorentina Roviezzo Antonietta Rossi Elisabetta Caiazzo Pierangelo Orlando Maria A. Riemma Valentina M. Iacono Andrea Guarino Armando Ialenti Carla Cicala Alessio Peritore Raffaele Capasso Vincenzo Di Marzo Angelo A. Izzo
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doi_str_mv	10.3389/fphar.2017.00857
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title_sort	palmitoylethanolamide supplementation during sensitization prevents airway allergic symptoms in the mouse
callnumber	RM1-950
title_auth	Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
abstract	One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features.
abstractGer	One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features.
abstract_unstemmed	One important risk factor for the development of asthma is allergen sensitization. Recent increasing evidence suggests a prominent role of mast cells in asthma pathophysiology. Since Palmitoylethanolamide (PEA), an endogenous lipid mediator chemically related to – and co-released with- the endocannabinoid anandamide, behaves as a local autacoid down-regulator of mast cell activation and inflammation, we explored the possible contribution of PEA in allergic sensitization, by using ovalbumin (OVA) as sensitizing agent in the mouse. PEA levels were dramatically reduced in the bronchi of OVA-treated animals. This effect was coupled to a significant up-regulation of CB2 and GPR55 receptors, two of the proposed molecular PEA targets, in bronchi harvested from allergen-sensitized mice. PEA supplementation (10 mg/kg, 15 min before each allergen exposure) prevented OVA-induced bronchial hyperreactivity, but it did not affect IgE plasma increase. On the other hand, PEA abrogated allergen-induced cell recruitment as well as pulmonary inflammation. Evaluation of pulmonary sections evidenced a significant inhibitory action of PEA on pulmonary mast cell recruitment and degranulation, an effect coupled to a reduction of leukotriene C4 production. These findings demonstrate that allergen sensitization negatively affects PEA bronchial levels and suggest that its supplementation has the potential to prevent the development of asthma-like features.
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title_short	Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse
url	https://doi.org/10.3389/fphar.2017.00857 https://doaj.org/article/84d8cb0cc2214f2a86ffc0e1706eff38 http://journal.frontiersin.org/article/10.3389/fphar.2017.00857/full https://doaj.org/toc/1663-9812
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author2	Antonietta Rossi Elisabetta Caiazzo Pierangelo Orlando Maria A. Riemma Valentina M. Iacono Andrea Guarino Armando Ialenti Carla Cicala Alessio Peritore Raffaele Capasso Vincenzo Di Marzo Angelo A. Izzo
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up_date	2024-07-03T17:52:31.880Z
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Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse

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