AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA
Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidativ...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
O.Ya. Barabash [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures |
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| Übergeordnetes Werk: |
In: Медична наука України - Bogomolets National Medical University, 2020, 18(2022), 2, Seite 39-44 |
|---|---|
| Übergeordnetes Werk: |
volume:18 ; year:2022 ; number:2 ; pages:39-44 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.32345/2664-4738.2.2022.06 |
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DOAJ035961759 |
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| 245 | 1 | 0 | |a AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA |
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| 520 | |a Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). | ||
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10.32345/2664-4738.2.2022.06 doi (DE-627)DOAJ035961759 (DE-599)DOAJ206914a1b30340d1bbfb1431cb6b96a5 DE-627 ger DE-627 rakwb eng rus ukr O.Ya. Barabash verfasserin aut AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures Medicine R In Медична наука України Bogomolets National Medical University, 2020 18(2022), 2, Seite 39-44 (DE-627)1694947874 26644738 nnns volume:18 year:2022 number:2 pages:39-44 https://doi.org/10.32345/2664-4738.2.2022.06 kostenfrei https://doaj.org/article/206914a1b30340d1bbfb1431cb6b96a5 kostenfrei https://msu-journal.com/index.php/journal/article/view/368 kostenfrei https://doaj.org/toc/2664-472X Journal toc kostenfrei https://doaj.org/toc/2664-4738 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 2 39-44 |
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10.32345/2664-4738.2.2022.06 doi (DE-627)DOAJ035961759 (DE-599)DOAJ206914a1b30340d1bbfb1431cb6b96a5 DE-627 ger DE-627 rakwb eng rus ukr O.Ya. Barabash verfasserin aut AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures Medicine R In Медична наука України Bogomolets National Medical University, 2020 18(2022), 2, Seite 39-44 (DE-627)1694947874 26644738 nnns volume:18 year:2022 number:2 pages:39-44 https://doi.org/10.32345/2664-4738.2.2022.06 kostenfrei https://doaj.org/article/206914a1b30340d1bbfb1431cb6b96a5 kostenfrei https://msu-journal.com/index.php/journal/article/view/368 kostenfrei https://doaj.org/toc/2664-472X Journal toc kostenfrei https://doaj.org/toc/2664-4738 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 2 39-44 |
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10.32345/2664-4738.2.2022.06 doi (DE-627)DOAJ035961759 (DE-599)DOAJ206914a1b30340d1bbfb1431cb6b96a5 DE-627 ger DE-627 rakwb eng rus ukr O.Ya. Barabash verfasserin aut AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures Medicine R In Медична наука України Bogomolets National Medical University, 2020 18(2022), 2, Seite 39-44 (DE-627)1694947874 26644738 nnns volume:18 year:2022 number:2 pages:39-44 https://doi.org/10.32345/2664-4738.2.2022.06 kostenfrei https://doaj.org/article/206914a1b30340d1bbfb1431cb6b96a5 kostenfrei https://msu-journal.com/index.php/journal/article/view/368 kostenfrei https://doaj.org/toc/2664-472X Journal toc kostenfrei https://doaj.org/toc/2664-4738 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 2 39-44 |
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10.32345/2664-4738.2.2022.06 doi (DE-627)DOAJ035961759 (DE-599)DOAJ206914a1b30340d1bbfb1431cb6b96a5 DE-627 ger DE-627 rakwb eng rus ukr O.Ya. Barabash verfasserin aut AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures Medicine R In Медична наука України Bogomolets National Medical University, 2020 18(2022), 2, Seite 39-44 (DE-627)1694947874 26644738 nnns volume:18 year:2022 number:2 pages:39-44 https://doi.org/10.32345/2664-4738.2.2022.06 kostenfrei https://doaj.org/article/206914a1b30340d1bbfb1431cb6b96a5 kostenfrei https://msu-journal.com/index.php/journal/article/view/368 kostenfrei https://doaj.org/toc/2664-472X Journal toc kostenfrei https://doaj.org/toc/2664-4738 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2022 2 39-44 |
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O.Ya. Barabash misc lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures misc Medicine misc R AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA |
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AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA lipoperoxidation, antioxidant system, oral fluid, partial and complete anodontia, dentures |
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AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA |
| abstract |
Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). |
| abstractGer |
Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). |
| abstract_unstemmed |
Relevance. The study is conditioned by a steady tendency of demographic aging of the population. On the part of the dental system, one of the most common age-related disorders is the tooth loss and the necessity to replace dentition defects. Changes in dental status can affect the course of oxidative reactions and antiradical protection of the oral fluid. Objective is to investigate the age peculiarities of the prooxidant-antioxidant balance of the oral fluid against the background of intact dentitions, partial and complete anodontia and their correction. Material and methods. There were examined 103 patients aged from 16 to 89, with intact dentitions, under the conditions of partial anodontia and correction with bridges or partial removable laminar dentures and complete anodontia and correction with complete removable laminar dentures. The intensity of the processes of free radical oxidation of lipids in oral fluid was assessed by the content of diene conjugates (DC) and products that respond to thiobarbituric acid (TBA-AP). The antioxidant reserve of the oral fluid was characterized according to the activity of superoxide dismutase (SOD), glutathione peroxidase (GP) and glutathione reductase (GR). Results. There was a significant increase of the indices of lipid peroxidation in the oral fluid, especially in middle-aged patients, which is confirmed by an increase in the content of DC and TBA-AP 5.9- and 4.5-fold, respectively, compared with data in adolescents. Such changes were consistent with a decrease in the activity of SOD, GP, GR of the oral fluid at 41.7-48.8% (p<0.05) relative to the values in adolescence. In elderly and senile patients, the level of lipid peroxidation tended to decrease. The activity of antioxidant enzymes in elderly patients decreased at 28.6-49.8% (p<0.05), in the senile patients – at 29.6-63.6% (p<0.05) relative to the values in the middle-aged patients. There has been an increase in the level of oxidative processes against the background of suppression of antiradical protection of the oral fluid in patients with partial or complete anodontia according to the data in the studied patients with intact dentitions, especially for people who use dentures. Conclusions. Prooxidant-antioxidant balance of the oral fluid depends on age and dental status. The most significant changes in oxidative processes in the oral fluid are observed in the middle-aged people with a tendency to decrease in the elderly and senile patients. The level of free radical processes increases under the conditions of partial and complete anodontia, correction of various types of denture designs and depends on the material they were made of. Such changes occur against the background of suppression of the antioxidant reserve of the oral fluid (especially the glutathione system). |
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| title_short |
AGE PECULIARITIES OF PROOXIDANT-ANTIOXIDANT BALANCE OF THE ORAL FLUID IN PATIENTS AGAINST THE BACKGROUND OF INTAKT DENTITIONS, PARTIAL AND COMPLETE ANODONTIA |
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https://doi.org/10.32345/2664-4738.2.2022.06 https://doaj.org/article/206914a1b30340d1bbfb1431cb6b96a5 https://msu-journal.com/index.php/journal/article/view/368 https://doaj.org/toc/2664-472X https://doaj.org/toc/2664-4738 |
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