Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis

Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation b...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giuseppa ePiras [verfasserIn] Lorenza eRattazzi [verfasserIn] Adam eMcDermott [verfasserIn] Robert eDeacon [verfasserIn] Fulvio eD'acquisto [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Behavior, Animal Immunomodulation Mood Disorders T cells autoimmunity models

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 4(2013)
Übergeordnetes Werk:	volume:4 ; year:2013

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2013.00400

Katalog-ID:	DOAJ035966688

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spelling	10.3389/fimmu.2013.00400 doi (DE-627)DOAJ035966688 (DE-599)DOAJe29fd15ecbaf42d09d83bc9f1429d3e7 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppa ePiras verfasserin aut Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity. Behavior, Animal Immunomodulation Mood Disorders T cells autoimmunity models Immunologic diseases. Allergy Lorenza eRattazzi verfasserin aut Adam eMcDermott verfasserin aut Robert eDeacon verfasserin aut Fulvio eD'acquisto verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 4(2013) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:4 year:2013 https://doi.org/10.3389/fimmu.2013.00400 kostenfrei https://doaj.org/article/e29fd15ecbaf42d09d83bc9f1429d3e7 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00400/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013
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allfieldsGer	10.3389/fimmu.2013.00400 doi (DE-627)DOAJ035966688 (DE-599)DOAJe29fd15ecbaf42d09d83bc9f1429d3e7 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppa ePiras verfasserin aut Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity. Behavior, Animal Immunomodulation Mood Disorders T cells autoimmunity models Immunologic diseases. Allergy Lorenza eRattazzi verfasserin aut Adam eMcDermott verfasserin aut Robert eDeacon verfasserin aut Fulvio eD'acquisto verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 4(2013) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:4 year:2013 https://doi.org/10.3389/fimmu.2013.00400 kostenfrei https://doaj.org/article/e29fd15ecbaf42d09d83bc9f1429d3e7 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00400/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013
allfieldsSound	10.3389/fimmu.2013.00400 doi (DE-627)DOAJ035966688 (DE-599)DOAJe29fd15ecbaf42d09d83bc9f1429d3e7 DE-627 ger DE-627 rakwb eng RC581-607 Giuseppa ePiras verfasserin aut Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity. Behavior, Animal Immunomodulation Mood Disorders T cells autoimmunity models Immunologic diseases. Allergy Lorenza eRattazzi verfasserin aut Adam eMcDermott verfasserin aut Robert eDeacon verfasserin aut Fulvio eD'acquisto verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 4(2013) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:4 year:2013 https://doi.org/10.3389/fimmu.2013.00400 kostenfrei https://doaj.org/article/e29fd15ecbaf42d09d83bc9f1429d3e7 kostenfrei http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00400/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013
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topic_title	RC581-607 Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis Behavior, Animal Immunomodulation Mood Disorders T cells autoimmunity models
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title	Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis
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title_auth	Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis
abstract	Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity.
abstractGer	Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity.
abstract_unstemmed	Autoimmune diseases like multiple sclerosis are known to be associated with debilitating emotional disorders that manifest long before the flaring of motor dysfunctions. Given the emerging role of T cells in controlling both emotions and autoimmunity, in this study we explored possible correlation between T cell activation and changes in emotional behavior in a mouse model of multiple sclerosis. Our results showed a significant increase in blood circulating T cells as soon as at day 4 post-immunization. This lymphocytosis remained stable with time and preceded the infiltration of T cell in the CNS. The kinetic of T cell entry in the blood matched the kinetic of changes in behavior measured using the open field test. Treatment with glatiramer acetate, a well-known immunomodulatory drug for multiple sclerosis, suppressed behavioral changes while retaining the T cells in the draining lymph nodes. Together these results provide evidence of a positive correlation between the emigration of T cells in circulation and changes in emotions during chronic inflammatory diseases. The validation of these findings in the clinic might help to better understand the cause of the emotional and psychological burden of patients suffering multiple sclerosis or other autoimmune diseases. Most importantly our study suggests novel therapeutic venues for the treatment of the emotional changes associated with autoimmunity.
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title_short	Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis
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Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis

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