Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study

Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used...
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Autor*in:	Zhiliang Wei [verfasserIn] Lin Chen [verfasserIn] Xirui Hou [verfasserIn] Peter C. M. van Zijl [verfasserIn] Jiadi Xu [verfasserIn] Hanzhang Lu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6

Übergeordnetes Werk:	In: Frontiers in Neurology - Frontiers Media S.A., 2010, 11(2020)
Übergeordnetes Werk:	volume:11 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fneur.2020.00559

Katalog-ID:	DOAJ036115096

Internformat


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520			\|a Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice.
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653		0	\|a Neurology. Diseases of the nervous system
700	0		\|a Zhiliang Wei \|e verfasserin \|4 aut
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700	0		\|a Peter C. M. van Zijl \|e verfasserin \|4 aut
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700	0		\|a Jiadi Xu \|e verfasserin \|4 aut
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700	0		\|a Hanzhang Lu \|e verfasserin \|4 aut
700	0		\|a Hanzhang Lu \|e verfasserin \|4 aut
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allfields	10.3389/fneur.2020.00559 doi (DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c DE-627 ger DE-627 rakwb eng RC346-429 Zhiliang Wei verfasserin aut Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice. aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system Zhiliang Wei verfasserin aut Lin Chen verfasserin aut Lin Chen verfasserin aut Xirui Hou verfasserin aut Peter C. M. van Zijl verfasserin aut Peter C. M. van Zijl verfasserin aut Jiadi Xu verfasserin aut Jiadi Xu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 11(2020) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:11 year:2020 https://doi.org/10.3389/fneur.2020.00559 kostenfrei https://doaj.org/article/6e8cc532408848f08f508060110f816c kostenfrei https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
spelling	10.3389/fneur.2020.00559 doi (DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c DE-627 ger DE-627 rakwb eng RC346-429 Zhiliang Wei verfasserin aut Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice. aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system Zhiliang Wei verfasserin aut Lin Chen verfasserin aut Lin Chen verfasserin aut Xirui Hou verfasserin aut Peter C. M. van Zijl verfasserin aut Peter C. M. van Zijl verfasserin aut Jiadi Xu verfasserin aut Jiadi Xu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 11(2020) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:11 year:2020 https://doi.org/10.3389/fneur.2020.00559 kostenfrei https://doaj.org/article/6e8cc532408848f08f508060110f816c kostenfrei https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfields_unstemmed	10.3389/fneur.2020.00559 doi (DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c DE-627 ger DE-627 rakwb eng RC346-429 Zhiliang Wei verfasserin aut Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice. aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system Zhiliang Wei verfasserin aut Lin Chen verfasserin aut Lin Chen verfasserin aut Xirui Hou verfasserin aut Peter C. M. van Zijl verfasserin aut Peter C. M. van Zijl verfasserin aut Jiadi Xu verfasserin aut Jiadi Xu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 11(2020) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:11 year:2020 https://doi.org/10.3389/fneur.2020.00559 kostenfrei https://doaj.org/article/6e8cc532408848f08f508060110f816c kostenfrei https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsGer	10.3389/fneur.2020.00559 doi (DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c DE-627 ger DE-627 rakwb eng RC346-429 Zhiliang Wei verfasserin aut Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice. aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system Zhiliang Wei verfasserin aut Lin Chen verfasserin aut Lin Chen verfasserin aut Xirui Hou verfasserin aut Peter C. M. van Zijl verfasserin aut Peter C. M. van Zijl verfasserin aut Jiadi Xu verfasserin aut Jiadi Xu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 11(2020) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:11 year:2020 https://doi.org/10.3389/fneur.2020.00559 kostenfrei https://doaj.org/article/6e8cc532408848f08f508060110f816c kostenfrei https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
allfieldsSound	10.3389/fneur.2020.00559 doi (DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c DE-627 ger DE-627 rakwb eng RC346-429 Zhiliang Wei verfasserin aut Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice. aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system Zhiliang Wei verfasserin aut Lin Chen verfasserin aut Lin Chen verfasserin aut Xirui Hou verfasserin aut Peter C. M. van Zijl verfasserin aut Peter C. M. van Zijl verfasserin aut Jiadi Xu verfasserin aut Jiadi Xu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut Hanzhang Lu verfasserin aut In Frontiers in Neurology Frontiers Media S.A., 2010 11(2020) (DE-627)631498753 (DE-600)2564214-5 16642295 nnns volume:11 year:2020 https://doi.org/10.3389/fneur.2020.00559 kostenfrei https://doaj.org/article/6e8cc532408848f08f508060110f816c kostenfrei https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full kostenfrei https://doaj.org/toc/1664-2295 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2020
language	English
source	In Frontiers in Neurology 11(2020) volume:11 year:2020
sourceStr	In Frontiers in Neurology 11(2020) volume:11 year:2020
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topic_facet	aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6 Neurology. Diseases of the nervous system
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container_title	Frontiers in Neurology
authorswithroles_txt_mv	Zhiliang Wei @@aut@@ Lin Chen @@aut@@ Xirui Hou @@aut@@ Peter C. M. van Zijl @@aut@@ Jiadi Xu @@aut@@ Hanzhang Lu @@aut@@
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topic_title	RC346-429 Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study aging cerebral blood flow cerebral metabolic rate of oxygen longitudinal C57BL/6
topic	misc RC346-429 misc aging misc cerebral blood flow misc cerebral metabolic rate of oxygen misc longitudinal misc C57BL/6 misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC346-429 misc aging misc cerebral blood flow misc cerebral metabolic rate of oxygen misc longitudinal misc C57BL/6 misc Neurology. Diseases of the nervous system
topic_browse	misc RC346-429 misc aging misc cerebral blood flow misc cerebral metabolic rate of oxygen misc longitudinal misc C57BL/6 misc Neurology. Diseases of the nervous system
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title	Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study
ctrlnum	(DE-627)DOAJ036115096 (DE-599)DOAJ6e8cc532408848f08f508060110f816c
title_full	Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study
author_sort	Zhiliang Wei
journal	Frontiers in Neurology
journalStr	Frontiers in Neurology
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author_browse	Zhiliang Wei Lin Chen Xirui Hou Peter C. M. van Zijl Jiadi Xu Hanzhang Lu
container_volume	11
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format_se	Elektronische Aufsätze
author-letter	Zhiliang Wei
doi_str_mv	10.3389/fneur.2020.00559
author2-role	verfasserin
title_sort	age-related alterations in brain perfusion, venous oxygenation, and oxygen metabolic rate of mice: a 17-month longitudinal mri study
callnumber	RC346-429
title_auth	Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study
abstract	Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice.
abstractGer	Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice.
abstract_unstemmed	Background: Characterization of physiological parameters of the aging brain, such as perfusion and brain metabolism, is important for understanding brain function and diseases. Aging studies on human brain have mostly been based on the cross-sectional design, while the few longitudinal studies used relatively short follow-up time compared to the lifespan.Objectives: To determine the longitudinal time courses of cerebral physiological parameters across the adult lifespan in mice.Methods: The present work examined longitudinal changes in cerebral blood flow (CBF), cerebral venous oxygenation (Yv), and cerebral metabolic rate of oxygen (CMRO2) using MRI in healthy C57BL/6 mice from 3 to 20 months of age. Each mouse received 16 imaging sessions at an ~1-month interval.Results: Significant increases with age were observed in CBF (p = 0.017) and CMRO2 (p < 0.001). Meanwhile, Yv revealed a significant decrease (p = 0.002) with a non-linear pattern (p = 0.013). The rate of change was 0.87, 2.26, and −0.24% per month for CBF, CMRO2, and Yv, respectively. On the other hand, systemic parameters such as heart rate did not show a significant age dependence (p = 0.47). No white-matter-hyperintensities (WMH) were observed on the T2-weighted image at any age of the mice.Conclusion: With age, the mouse brain revealed an increase in oxygen consumption. This observation is consistent with previous findings in humans using a cross-sectional design and suggests a degradation of the brain's energy production or utilization machinery. Cerebral perfusion remains relatively intact in aged mice, at least until 20 months of age, consistent with the absence of WMH in mice.
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title_short	Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study
url	https://doi.org/10.3389/fneur.2020.00559 https://doaj.org/article/6e8cc532408848f08f508060110f816c https://www.frontiersin.org/article/10.3389/fneur.2020.00559/full https://doaj.org/toc/1664-2295
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author2	Zhiliang Wei Lin Chen Xirui Hou Peter C. M. van Zijl Jiadi Xu Hanzhang Lu
author2Str	Zhiliang Wei Lin Chen Xirui Hou Peter C. M. van Zijl Jiadi Xu Hanzhang Lu
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doi_str	10.3389/fneur.2020.00559
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up_date	2024-07-03T18:46:14.891Z
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