FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition

Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological...
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Autor*in:	Chen Yang [verfasserIn] Zheyu Zhang [verfasserIn] Fangdie Ye [verfasserIn] Zezhong Mou [verfasserIn] Xinan Chen [verfasserIn] Yuxi Ou [verfasserIn] Chenyang Xu [verfasserIn] Siqi Wu [verfasserIn] Zhang Cheng [verfasserIn] Jimeng Hu [verfasserIn] Lujia Zou [verfasserIn] Haowen Jiang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.01685

Katalog-ID:	DOAJ036237388

Internformat


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Indexfelder

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allfields	10.3389/fonc.2020.01685 doi (DE-627)DOAJ036237388 (DE-599)DOAJ4117add1becf4a1483a9f9e7f3e80687 DE-627 ger DE-627 rakwb eng RC254-282 Chen Yang verfasserin aut FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC. FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chen Yang verfasserin aut Chen Yang verfasserin aut Zheyu Zhang verfasserin aut Zheyu Zhang verfasserin aut Fangdie Ye verfasserin aut Fangdie Ye verfasserin aut Zezhong Mou verfasserin aut Zezhong Mou verfasserin aut Xinan Chen verfasserin aut Xinan Chen verfasserin aut Yuxi Ou verfasserin aut Yuxi Ou verfasserin aut Chenyang Xu verfasserin aut Chenyang Xu verfasserin aut Siqi Wu verfasserin aut Siqi Wu verfasserin aut Zhang Cheng verfasserin aut Zhang Cheng verfasserin aut Jimeng Hu verfasserin aut Jimeng Hu verfasserin aut Lujia Zou verfasserin aut Lujia Zou verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01685 kostenfrei https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
spelling	10.3389/fonc.2020.01685 doi (DE-627)DOAJ036237388 (DE-599)DOAJ4117add1becf4a1483a9f9e7f3e80687 DE-627 ger DE-627 rakwb eng RC254-282 Chen Yang verfasserin aut FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC. FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chen Yang verfasserin aut Chen Yang verfasserin aut Zheyu Zhang verfasserin aut Zheyu Zhang verfasserin aut Fangdie Ye verfasserin aut Fangdie Ye verfasserin aut Zezhong Mou verfasserin aut Zezhong Mou verfasserin aut Xinan Chen verfasserin aut Xinan Chen verfasserin aut Yuxi Ou verfasserin aut Yuxi Ou verfasserin aut Chenyang Xu verfasserin aut Chenyang Xu verfasserin aut Siqi Wu verfasserin aut Siqi Wu verfasserin aut Zhang Cheng verfasserin aut Zhang Cheng verfasserin aut Jimeng Hu verfasserin aut Jimeng Hu verfasserin aut Lujia Zou verfasserin aut Lujia Zou verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01685 kostenfrei https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfields_unstemmed	10.3389/fonc.2020.01685 doi (DE-627)DOAJ036237388 (DE-599)DOAJ4117add1becf4a1483a9f9e7f3e80687 DE-627 ger DE-627 rakwb eng RC254-282 Chen Yang verfasserin aut FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC. FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chen Yang verfasserin aut Chen Yang verfasserin aut Zheyu Zhang verfasserin aut Zheyu Zhang verfasserin aut Fangdie Ye verfasserin aut Fangdie Ye verfasserin aut Zezhong Mou verfasserin aut Zezhong Mou verfasserin aut Xinan Chen verfasserin aut Xinan Chen verfasserin aut Yuxi Ou verfasserin aut Yuxi Ou verfasserin aut Chenyang Xu verfasserin aut Chenyang Xu verfasserin aut Siqi Wu verfasserin aut Siqi Wu verfasserin aut Zhang Cheng verfasserin aut Zhang Cheng verfasserin aut Jimeng Hu verfasserin aut Jimeng Hu verfasserin aut Lujia Zou verfasserin aut Lujia Zou verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01685 kostenfrei https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsGer	10.3389/fonc.2020.01685 doi (DE-627)DOAJ036237388 (DE-599)DOAJ4117add1becf4a1483a9f9e7f3e80687 DE-627 ger DE-627 rakwb eng RC254-282 Chen Yang verfasserin aut FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC. FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chen Yang verfasserin aut Chen Yang verfasserin aut Zheyu Zhang verfasserin aut Zheyu Zhang verfasserin aut Fangdie Ye verfasserin aut Fangdie Ye verfasserin aut Zezhong Mou verfasserin aut Zezhong Mou verfasserin aut Xinan Chen verfasserin aut Xinan Chen verfasserin aut Yuxi Ou verfasserin aut Yuxi Ou verfasserin aut Chenyang Xu verfasserin aut Chenyang Xu verfasserin aut Siqi Wu verfasserin aut Siqi Wu verfasserin aut Zhang Cheng verfasserin aut Zhang Cheng verfasserin aut Jimeng Hu verfasserin aut Jimeng Hu verfasserin aut Lujia Zou verfasserin aut Lujia Zou verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01685 kostenfrei https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsSound	10.3389/fonc.2020.01685 doi (DE-627)DOAJ036237388 (DE-599)DOAJ4117add1becf4a1483a9f9e7f3e80687 DE-627 ger DE-627 rakwb eng RC254-282 Chen Yang verfasserin aut FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC. FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chen Yang verfasserin aut Chen Yang verfasserin aut Zheyu Zhang verfasserin aut Zheyu Zhang verfasserin aut Fangdie Ye verfasserin aut Fangdie Ye verfasserin aut Zezhong Mou verfasserin aut Zezhong Mou verfasserin aut Xinan Chen verfasserin aut Xinan Chen verfasserin aut Yuxi Ou verfasserin aut Yuxi Ou verfasserin aut Chenyang Xu verfasserin aut Chenyang Xu verfasserin aut Siqi Wu verfasserin aut Siqi Wu verfasserin aut Zhang Cheng verfasserin aut Zhang Cheng verfasserin aut Jimeng Hu verfasserin aut Jimeng Hu verfasserin aut Lujia Zou verfasserin aut Lujia Zou verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut Haowen Jiang verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.01685 kostenfrei https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
language	English
source	In Frontiers in Oncology 10(2020) volume:10 year:2020
sourceStr	In Frontiers in Oncology 10(2020) volume:10 year:2020
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Frontiers in Oncology
authorswithroles_txt_mv	Chen Yang @@aut@@ Zheyu Zhang @@aut@@ Fangdie Ye @@aut@@ Zezhong Mou @@aut@@ Xinan Chen @@aut@@ Yuxi Ou @@aut@@ Chenyang Xu @@aut@@ Siqi Wu @@aut@@ Zhang Cheng @@aut@@ Jimeng Hu @@aut@@ Lujia Zou @@aut@@ Haowen Jiang @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	684965518
id	DOAJ036237388
language_de	englisch
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callnumber-first	R - Medicine
author	Chen Yang
spellingShingle	Chen Yang misc RC254-282 misc FGF18 misc epithelial-mesenchymal transition misc clear cell renal cell carcinoma misc proliferation misc invasion misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition
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topic_title	RC254-282 FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition FGF18 epithelial-mesenchymal transition clear cell renal cell carcinoma proliferation invasion
topic	misc RC254-282 misc FGF18 misc epithelial-mesenchymal transition misc clear cell renal cell carcinoma misc proliferation misc invasion misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc FGF18 misc epithelial-mesenchymal transition misc clear cell renal cell carcinoma misc proliferation misc invasion misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc FGF18 misc epithelial-mesenchymal transition misc clear cell renal cell carcinoma misc proliferation misc invasion misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition
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title_full	FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition
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author_browse	Chen Yang Zheyu Zhang Fangdie Ye Zezhong Mou Xinan Chen Yuxi Ou Chenyang Xu Siqi Wu Zhang Cheng Jimeng Hu Lujia Zou Haowen Jiang
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title_sort	fgf18 inhibits clear cell renal cell carcinoma proliferation and invasion via regulating epithelial-mesenchymal transition
callnumber	RC254-282
title_auth	FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition
abstract	Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC.
abstractGer	Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC.
abstract_unstemmed	Fibroblast growth factor 18 (FGF18) is a member of the FGF family and contributes to a broad range of biological events. The important role of the overexpression of FGF18 has been identified in the progression of several types of cancers. However, there is still little information on the biological role of FGF18 on clear cell renal cell carcinoma (ccRCC), which is of interest in investigating the biological functions of FGF18 in ccRCC. Our results showed that FGF18 was lowly expressed in ccRCC tissues compared to paired normal renal tissue from the TCGA database and clinical cohort of Huashan Hospital and that high expression of FGF18 correlated with a good prognosis in ccRCC patients. In addition, overexpression of FGF18 significantly inhibited the proliferation ability of ccRCC cell lines in vitro and in vivo. Gene set enrichment analysis (GSEA) identified epithelial-mesenchymal transition (EMT) involved in a high FGF18 expression group of ccRCC patients in the TCGA cohort, which was further validated with EMT related markers in FGF18 overexpressed ccRCC cell lines. Furthermore, FGF18 overexpression significantly inhibited the PI3K/Akt pathway in ccRCC cells. Taken together, this study concludes that FGF18 is of potential value as a target for ccRCC.
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title_short	FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition
url	https://doi.org/10.3389/fonc.2020.01685 https://doaj.org/article/4117add1becf4a1483a9f9e7f3e80687 https://www.frontiersin.org/article/10.3389/fonc.2020.01685/full https://doaj.org/toc/2234-943X
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up_date	2024-07-03T19:27:35.881Z
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FGF18 Inhibits Clear Cell Renal Cell Carcinoma Proliferation and Invasion via Regulating Epithelial-Mesenchymal Transition

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