Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces
Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design:...
Ausführliche Beschreibung
Autor*in: |
Sébastien Wurtzer [verfasserIn] Sandra Lacote [verfasserIn] Severine Murri [verfasserIn] Philippe Marianneau [verfasserIn] Elodie Monchatre-Leroy [verfasserIn] Mickaël Boni [verfasserIn] Olivier Ferraris [verfasserIn] Yvon Maday [verfasserIn] Ousmane Kébé [verfasserIn] Ndongo Dia [verfasserIn] Christophe Peyrefitte [verfasserIn] Harry Sokol [verfasserIn] OBEPINE Consortium [verfasserIn] Laurent Moulin [verfasserIn] Vincent Maréchal [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Viruses - MDPI AG, 2009, 14(2022), 8, p 1777 |
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Übergeordnetes Werk: |
volume:14 ; year:2022 ; number:8, p 1777 |
Links: |
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DOI / URN: |
10.3390/v14081777 |
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Katalog-ID: |
DOAJ036257540 |
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10.3390/v14081777 doi (DE-627)DOAJ036257540 (DE-599)DOAJ154717b3e1a34f5b816a9ed07c313f31 DE-627 ger DE-627 rakwb eng QR1-502 Sébastien Wurtzer verfasserin aut Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. SARS-CoV-2 transmission feces stool persistence infectivity Microbiology Sandra Lacote verfasserin aut Severine Murri verfasserin aut Philippe Marianneau verfasserin aut Elodie Monchatre-Leroy verfasserin aut Mickaël Boni verfasserin aut Olivier Ferraris verfasserin aut Yvon Maday verfasserin aut Ousmane Kébé verfasserin aut Ndongo Dia verfasserin aut Christophe Peyrefitte verfasserin aut Harry Sokol verfasserin aut OBEPINE Consortium verfasserin aut Laurent Moulin verfasserin aut Vincent Maréchal verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1777 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1777 https://doi.org/10.3390/v14081777 kostenfrei https://doaj.org/article/154717b3e1a34f5b816a9ed07c313f31 kostenfrei https://www.mdpi.com/1999-4915/14/8/1777 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1777 |
spelling |
10.3390/v14081777 doi (DE-627)DOAJ036257540 (DE-599)DOAJ154717b3e1a34f5b816a9ed07c313f31 DE-627 ger DE-627 rakwb eng QR1-502 Sébastien Wurtzer verfasserin aut Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. SARS-CoV-2 transmission feces stool persistence infectivity Microbiology Sandra Lacote verfasserin aut Severine Murri verfasserin aut Philippe Marianneau verfasserin aut Elodie Monchatre-Leroy verfasserin aut Mickaël Boni verfasserin aut Olivier Ferraris verfasserin aut Yvon Maday verfasserin aut Ousmane Kébé verfasserin aut Ndongo Dia verfasserin aut Christophe Peyrefitte verfasserin aut Harry Sokol verfasserin aut OBEPINE Consortium verfasserin aut Laurent Moulin verfasserin aut Vincent Maréchal verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1777 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1777 https://doi.org/10.3390/v14081777 kostenfrei https://doaj.org/article/154717b3e1a34f5b816a9ed07c313f31 kostenfrei https://www.mdpi.com/1999-4915/14/8/1777 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1777 |
allfields_unstemmed |
10.3390/v14081777 doi (DE-627)DOAJ036257540 (DE-599)DOAJ154717b3e1a34f5b816a9ed07c313f31 DE-627 ger DE-627 rakwb eng QR1-502 Sébastien Wurtzer verfasserin aut Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. SARS-CoV-2 transmission feces stool persistence infectivity Microbiology Sandra Lacote verfasserin aut Severine Murri verfasserin aut Philippe Marianneau verfasserin aut Elodie Monchatre-Leroy verfasserin aut Mickaël Boni verfasserin aut Olivier Ferraris verfasserin aut Yvon Maday verfasserin aut Ousmane Kébé verfasserin aut Ndongo Dia verfasserin aut Christophe Peyrefitte verfasserin aut Harry Sokol verfasserin aut OBEPINE Consortium verfasserin aut Laurent Moulin verfasserin aut Vincent Maréchal verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1777 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1777 https://doi.org/10.3390/v14081777 kostenfrei https://doaj.org/article/154717b3e1a34f5b816a9ed07c313f31 kostenfrei https://www.mdpi.com/1999-4915/14/8/1777 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1777 |
allfieldsGer |
10.3390/v14081777 doi (DE-627)DOAJ036257540 (DE-599)DOAJ154717b3e1a34f5b816a9ed07c313f31 DE-627 ger DE-627 rakwb eng QR1-502 Sébastien Wurtzer verfasserin aut Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. SARS-CoV-2 transmission feces stool persistence infectivity Microbiology Sandra Lacote verfasserin aut Severine Murri verfasserin aut Philippe Marianneau verfasserin aut Elodie Monchatre-Leroy verfasserin aut Mickaël Boni verfasserin aut Olivier Ferraris verfasserin aut Yvon Maday verfasserin aut Ousmane Kébé verfasserin aut Ndongo Dia verfasserin aut Christophe Peyrefitte verfasserin aut Harry Sokol verfasserin aut OBEPINE Consortium verfasserin aut Laurent Moulin verfasserin aut Vincent Maréchal verfasserin aut In Viruses MDPI AG, 2009 14(2022), 8, p 1777 (DE-627)609775871 (DE-600)2516098-9 19994915 nnns volume:14 year:2022 number:8, p 1777 https://doi.org/10.3390/v14081777 kostenfrei https://doaj.org/article/154717b3e1a34f5b816a9ed07c313f31 kostenfrei https://www.mdpi.com/1999-4915/14/8/1777 kostenfrei https://doaj.org/toc/1999-4915 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2022 8, p 1777 |
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reduction in sars-cov-2 virus infectivity in human and hamster feces |
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title_auth |
Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces |
abstract |
Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. |
abstractGer |
Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. |
abstract_unstemmed |
Objective: There is extensive evidence that SARS-CoV-2 replicates in the gastrointestinal tract. However, the infectivity of virions in feces is poorly documented. Although the primary mode of transmission is airborne, the risk of transmission from contaminated feces remains to be assessed. Design: The persistence of SARS-CoV-2 (infectivity and RNA) in human and animal feces was evaluated by virus isolation on cell culture and RT-qPCR, respectively. The exposure of golden Syrian hamsters to experimentally contaminated feces through intranasal inoculation has also been tested to assess the fecal-oral transmission route. Results: For periods that are compatible with average intestinal transit, the SARS-CoV-2 genome was noticeably stable in human and animal feces, contrary to the virus infectivity that was reduced in a time- and temperature-dependent manner. In human stools, this reduction was variable depending on the donors. Viral RNA was excreted in the feces of infected hamsters, but exposure of naïve hamsters to feces of infected animals did not lead to any productive infection. Conversely, hamsters could be experimentally infected following exposure to spiked fresh feces. Conclusion: Infection following exposure to naturally contaminated feces has been suspected but has not been established so far. The present work demonstrates that SARS-CoV-2 rapidly lost infectivity in spiked or naturally infected feces. Although the possibility of persistent viral particles in human or animal feces cannot be fully ruled out, SARS-CoV-2 transmission after exposure to contaminated feces is unlikely. |
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container_issue |
8, p 1777 |
title_short |
Reduction in SARS-CoV-2 Virus Infectivity in Human and Hamster Feces |
url |
https://doi.org/10.3390/v14081777 https://doaj.org/article/154717b3e1a34f5b816a9ed07c313f31 https://www.mdpi.com/1999-4915/14/8/1777 https://doaj.org/toc/1999-4915 |
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Sandra Lacote Severine Murri Philippe Marianneau Elodie Monchatre-Leroy Mickaël Boni Olivier Ferraris Yvon Maday Ousmane Kébé Ndongo Dia Christophe Peyrefitte Harry Sokol OBEPINE Consortium Laurent Moulin Vincent Maréchal |
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up_date |
2024-07-03T19:34:18.759Z |
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