Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces

Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-...
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Autor*in:	Hans-Frieder Schött [verfasserIn] Esther W. L. Chua [verfasserIn] Sartaj Ahmad Mir [verfasserIn] Bo Burla [verfasserIn] Anne K. Bendt [verfasserIn] Markus R. Wenk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	bile acids human feces human stool normalization wet weight dry weight

Übergeordnetes Werk:	In: Metabolites - MDPI AG, 2012, 12(2022), 8, p 723
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:8, p 723

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/metabo12080723

Katalog-ID:	DOAJ036313858

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520			\|a Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-individual variability. To compare bile acid concentrations among different individuals, a reliable normalization approach is needed. Here, we compared the impact of three normalization approaches, namely sample wet weight, dry weight, and protein concentration, on the absolute concentrations of fecal bile acids. Bile acid concentrations were determined in 70 feces samples from healthy humans. Our data show that bile acid concentrations normalized by the three different approaches are substantially different for each individual sample. Fecal bile acid concentrations normalized by wet weight show the narrowest distribution. Therefore, our analysis will provide the basis for the selection of a suitable normalization approach for the quantitative analysis of bile acids in feces.
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allfieldsGer	10.3390/metabo12080723 doi (DE-627)DOAJ036313858 (DE-599)DOAJ66e4745597654f99a32e1ca6c69c9f93 DE-627 ger DE-627 rakwb eng QR1-502 Hans-Frieder Schött verfasserin aut Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-individual variability. To compare bile acid concentrations among different individuals, a reliable normalization approach is needed. Here, we compared the impact of three normalization approaches, namely sample wet weight, dry weight, and protein concentration, on the absolute concentrations of fecal bile acids. Bile acid concentrations were determined in 70 feces samples from healthy humans. Our data show that bile acid concentrations normalized by the three different approaches are substantially different for each individual sample. Fecal bile acid concentrations normalized by wet weight show the narrowest distribution. Therefore, our analysis will provide the basis for the selection of a suitable normalization approach for the quantitative analysis of bile acids in feces. bile acids human feces human stool normalization wet weight dry weight Microbiology Esther W. L. Chua verfasserin aut Sartaj Ahmad Mir verfasserin aut Bo Burla verfasserin aut Anne K. Bendt verfasserin aut Markus R. Wenk verfasserin aut In Metabolites MDPI AG, 2012 12(2022), 8, p 723 (DE-627)718627164 (DE-600)2662251-8 22181989 nnns volume:12 year:2022 number:8, p 723 https://doi.org/10.3390/metabo12080723 kostenfrei https://doaj.org/article/66e4745597654f99a32e1ca6c69c9f93 kostenfrei https://www.mdpi.com/2218-1989/12/8/723 kostenfrei https://doaj.org/toc/2218-1989 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 8, p 723
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language	English
source	In Metabolites 12(2022), 8, p 723 volume:12 year:2022 number:8, p 723
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authorswithroles_txt_mv	Hans-Frieder Schött @@aut@@ Esther W. L. Chua @@aut@@ Sartaj Ahmad Mir @@aut@@ Bo Burla @@aut@@ Anne K. Bendt @@aut@@ Markus R. Wenk @@aut@@
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callnumber-first	Q - Science
author	Hans-Frieder Schött
spellingShingle	Hans-Frieder Schött misc QR1-502 misc bile acids misc human feces misc human stool misc normalization misc wet weight misc dry weight misc Microbiology Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces
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topic_title	QR1-502 Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces bile acids human feces human stool normalization wet weight dry weight
topic	misc QR1-502 misc bile acids misc human feces misc human stool misc normalization misc wet weight misc dry weight misc Microbiology
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title_sort	evaluation of normalization approaches for quantitative analysis of bile acids in human feces
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title_auth	Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces
abstract	Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-individual variability. To compare bile acid concentrations among different individuals, a reliable normalization approach is needed. Here, we compared the impact of three normalization approaches, namely sample wet weight, dry weight, and protein concentration, on the absolute concentrations of fecal bile acids. Bile acid concentrations were determined in 70 feces samples from healthy humans. Our data show that bile acid concentrations normalized by the three different approaches are substantially different for each individual sample. Fecal bile acid concentrations normalized by wet weight show the narrowest distribution. Therefore, our analysis will provide the basis for the selection of a suitable normalization approach for the quantitative analysis of bile acids in feces.
abstractGer	Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-individual variability. To compare bile acid concentrations among different individuals, a reliable normalization approach is needed. Here, we compared the impact of three normalization approaches, namely sample wet weight, dry weight, and protein concentration, on the absolute concentrations of fecal bile acids. Bile acid concentrations were determined in 70 feces samples from healthy humans. Our data show that bile acid concentrations normalized by the three different approaches are substantially different for each individual sample. Fecal bile acid concentrations normalized by wet weight show the narrowest distribution. Therefore, our analysis will provide the basis for the selection of a suitable normalization approach for the quantitative analysis of bile acids in feces.
abstract_unstemmed	Quantitative analysis of bile acids in human feces can potentially help to better understand the influence of the gut microbiome and diet on human health. Feces is a highly heterogeneous sample matrix, mainly consisting of water and indigestible solid material (as plant fibers) that show high inter-individual variability. To compare bile acid concentrations among different individuals, a reliable normalization approach is needed. Here, we compared the impact of three normalization approaches, namely sample wet weight, dry weight, and protein concentration, on the absolute concentrations of fecal bile acids. Bile acid concentrations were determined in 70 feces samples from healthy humans. Our data show that bile acid concentrations normalized by the three different approaches are substantially different for each individual sample. Fecal bile acid concentrations normalized by wet weight show the narrowest distribution. Therefore, our analysis will provide the basis for the selection of a suitable normalization approach for the quantitative analysis of bile acids in feces.
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title_short	Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces
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Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces

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