Cold Atmospheric Plasma Targeting Hematological Malignancies: Potentials and Problems of Clinical Translation
Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectiv...
Ausführliche Beschreibung
Autor*in: |
Sebastiano Gangemi [verfasserIn] Claudia Petrarca [verfasserIn] Alessandro Tonacci [verfasserIn] Mario Di Gioacchino [verfasserIn] Caterina Musolino [verfasserIn] Alessandro Allegra [verfasserIn] |
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E-Artikel |
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Englisch |
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2022 |
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Übergeordnetes Werk: |
In: Antioxidants - MDPI AG, 2013, 11(2022), 8, p 1592 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:8, p 1592 |
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DOI / URN: |
10.3390/antiox11081592 |
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Katalog-ID: |
DOAJ03636780X |
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10.3390/antiox11081592 doi (DE-627)DOAJ03636780X (DE-599)DOAJ3056d43cf9ee42d99b16c6519fdde85a DE-627 ger DE-627 rakwb eng RM1-950 Sebastiano Gangemi verfasserin aut Cold Atmospheric Plasma Targeting Hematological Malignancies: Potentials and Problems of Clinical Translation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. cold atmospheric plasma hematological malignancy oxidative stress apoptosis epigenetics angiogenesis Therapeutics. Pharmacology Claudia Petrarca verfasserin aut Alessandro Tonacci verfasserin aut Mario Di Gioacchino verfasserin aut Caterina Musolino verfasserin aut Alessandro Allegra verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 8, p 1592 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:8, p 1592 https://doi.org/10.3390/antiox11081592 kostenfrei https://doaj.org/article/3056d43cf9ee42d99b16c6519fdde85a kostenfrei https://www.mdpi.com/2076-3921/11/8/1592 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 8, p 1592 |
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10.3390/antiox11081592 doi (DE-627)DOAJ03636780X (DE-599)DOAJ3056d43cf9ee42d99b16c6519fdde85a DE-627 ger DE-627 rakwb eng RM1-950 Sebastiano Gangemi verfasserin aut Cold Atmospheric Plasma Targeting Hematological Malignancies: Potentials and Problems of Clinical Translation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. cold atmospheric plasma hematological malignancy oxidative stress apoptosis epigenetics angiogenesis Therapeutics. Pharmacology Claudia Petrarca verfasserin aut Alessandro Tonacci verfasserin aut Mario Di Gioacchino verfasserin aut Caterina Musolino verfasserin aut Alessandro Allegra verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 8, p 1592 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:8, p 1592 https://doi.org/10.3390/antiox11081592 kostenfrei https://doaj.org/article/3056d43cf9ee42d99b16c6519fdde85a kostenfrei https://www.mdpi.com/2076-3921/11/8/1592 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 8, p 1592 |
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10.3390/antiox11081592 doi (DE-627)DOAJ03636780X (DE-599)DOAJ3056d43cf9ee42d99b16c6519fdde85a DE-627 ger DE-627 rakwb eng RM1-950 Sebastiano Gangemi verfasserin aut Cold Atmospheric Plasma Targeting Hematological Malignancies: Potentials and Problems of Clinical Translation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. cold atmospheric plasma hematological malignancy oxidative stress apoptosis epigenetics angiogenesis Therapeutics. Pharmacology Claudia Petrarca verfasserin aut Alessandro Tonacci verfasserin aut Mario Di Gioacchino verfasserin aut Caterina Musolino verfasserin aut Alessandro Allegra verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 8, p 1592 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:8, p 1592 https://doi.org/10.3390/antiox11081592 kostenfrei https://doaj.org/article/3056d43cf9ee42d99b16c6519fdde85a kostenfrei https://www.mdpi.com/2076-3921/11/8/1592 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 8, p 1592 |
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10.3390/antiox11081592 doi (DE-627)DOAJ03636780X (DE-599)DOAJ3056d43cf9ee42d99b16c6519fdde85a DE-627 ger DE-627 rakwb eng RM1-950 Sebastiano Gangemi verfasserin aut Cold Atmospheric Plasma Targeting Hematological Malignancies: Potentials and Problems of Clinical Translation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. cold atmospheric plasma hematological malignancy oxidative stress apoptosis epigenetics angiogenesis Therapeutics. Pharmacology Claudia Petrarca verfasserin aut Alessandro Tonacci verfasserin aut Mario Di Gioacchino verfasserin aut Caterina Musolino verfasserin aut Alessandro Allegra verfasserin aut In Antioxidants MDPI AG, 2013 11(2022), 8, p 1592 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:11 year:2022 number:8, p 1592 https://doi.org/10.3390/antiox11081592 kostenfrei https://doaj.org/article/3056d43cf9ee42d99b16c6519fdde85a kostenfrei https://www.mdpi.com/2076-3921/11/8/1592 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 8, p 1592 |
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Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. |
abstractGer |
Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. |
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Cold atmospheric plasma is an ionized gas produced near room temperature; it generates reactive oxygen species and nitrogen species and induces physical changes, including ultraviolet, radiation, thermal, and electromagnetic effects. Several studies showed that cold atmospheric plasma could effectively provoke death in a huge amount of cell types, including neoplastic cells, via the induction of apoptosis, necrosis, and autophagy. This technique seems able to destroy tumor cells by disturbing their more susceptible redox equilibrium with respect to normal cells, but it is also able to cause immunogenic cell death by enhancing the immune response, to decrease angiogenesis, and to provoke genetic and epigenetics mutations. Solutions activated by cold gas plasma represent a new modality for treatment of less easily reached tumors, or hematological malignancies. Our review reports on accepted knowledge of cold atmospheric plasma’s effect on hematological malignancies, such as acute and chronic myeloid leukemia and multiple myeloma. Although relevant progress was made toward understanding the underlying mechanisms concerning the efficacy of cold atmospheric plasma in hematological tumors, there is a need to determine both guidelines and safety limits that guarantee an absence of long-term side effects. |
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