The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive

Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Falskov B [verfasserIn] Hermann [verfasserIn] Rask-Madsen [verfasserIn] Major-Pedersen [verfasserIn] Christiansen [verfasserIn] Raunsø [verfasserIn] Køber [verfasserIn] Torp-Pedersen C [verfasserIn] Dominguez [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Insulin resistance. Diabetes. Heart failure. Endothelial function

Übergeordnetes Werk:	In: Vascular Health and Risk Management - Dove Medical Press, 2009, (2011), Seite 771-776
Übergeordnetes Werk:	year:2011 ; pages:771-776

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ036368636

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allfields	(DE-627)DOAJ036368636 (DE-599)DOAJd90a0d2932574bc1a5c1673be9966f4d DE-627 ger DE-627 rakwb eng RC666-701 Falskov B verfasserin aut The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system Hermann verfasserin aut Rask-Madsen verfasserin aut Major-Pedersen verfasserin aut Christiansen verfasserin aut Raunsø verfasserin aut Køber verfasserin aut Torp-Pedersen C verfasserin aut Dominguez verfasserin aut In Vascular Health and Risk Management Dove Medical Press, 2009 (2011), Seite 771-776 (DE-627)481905839 (DE-600)2180578-7 11782048 nnns year:2011 pages:771-776 https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d kostenfrei https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM kostenfrei https://doaj.org/toc/1178-2048 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2011 771-776
spelling	(DE-627)DOAJ036368636 (DE-599)DOAJd90a0d2932574bc1a5c1673be9966f4d DE-627 ger DE-627 rakwb eng RC666-701 Falskov B verfasserin aut The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system Hermann verfasserin aut Rask-Madsen verfasserin aut Major-Pedersen verfasserin aut Christiansen verfasserin aut Raunsø verfasserin aut Køber verfasserin aut Torp-Pedersen C verfasserin aut Dominguez verfasserin aut In Vascular Health and Risk Management Dove Medical Press, 2009 (2011), Seite 771-776 (DE-627)481905839 (DE-600)2180578-7 11782048 nnns year:2011 pages:771-776 https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d kostenfrei https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM kostenfrei https://doaj.org/toc/1178-2048 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2011 771-776
allfields_unstemmed	(DE-627)DOAJ036368636 (DE-599)DOAJd90a0d2932574bc1a5c1673be9966f4d DE-627 ger DE-627 rakwb eng RC666-701 Falskov B verfasserin aut The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system Hermann verfasserin aut Rask-Madsen verfasserin aut Major-Pedersen verfasserin aut Christiansen verfasserin aut Raunsø verfasserin aut Køber verfasserin aut Torp-Pedersen C verfasserin aut Dominguez verfasserin aut In Vascular Health and Risk Management Dove Medical Press, 2009 (2011), Seite 771-776 (DE-627)481905839 (DE-600)2180578-7 11782048 nnns year:2011 pages:771-776 https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d kostenfrei https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM kostenfrei https://doaj.org/toc/1178-2048 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2011 771-776
allfieldsGer	(DE-627)DOAJ036368636 (DE-599)DOAJd90a0d2932574bc1a5c1673be9966f4d DE-627 ger DE-627 rakwb eng RC666-701 Falskov B verfasserin aut The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system Hermann verfasserin aut Rask-Madsen verfasserin aut Major-Pedersen verfasserin aut Christiansen verfasserin aut Raunsø verfasserin aut Køber verfasserin aut Torp-Pedersen C verfasserin aut Dominguez verfasserin aut In Vascular Health and Risk Management Dove Medical Press, 2009 (2011), Seite 771-776 (DE-627)481905839 (DE-600)2180578-7 11782048 nnns year:2011 pages:771-776 https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d kostenfrei https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM kostenfrei https://doaj.org/toc/1178-2048 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2011 771-776
allfieldsSound	(DE-627)DOAJ036368636 (DE-599)DOAJd90a0d2932574bc1a5c1673be9966f4d DE-627 ger DE-627 rakwb eng RC666-701 Falskov B verfasserin aut The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system Hermann verfasserin aut Rask-Madsen verfasserin aut Major-Pedersen verfasserin aut Christiansen verfasserin aut Raunsø verfasserin aut Køber verfasserin aut Torp-Pedersen C verfasserin aut Dominguez verfasserin aut In Vascular Health and Risk Management Dove Medical Press, 2009 (2011), Seite 771-776 (DE-627)481905839 (DE-600)2180578-7 11782048 nnns year:2011 pages:771-776 https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d kostenfrei https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM kostenfrei https://doaj.org/toc/1178-2048 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2011 771-776
language	English
source	In Vascular Health and Risk Management (2011), Seite 771-776 year:2011 pages:771-776
sourceStr	In Vascular Health and Risk Management (2011), Seite 771-776 year:2011 pages:771-776
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institution	findex.gbv.de
topic_facet	Insulin resistance. Diabetes. Heart failure. Endothelial function Diseases of the circulatory (Cardiovascular) system
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container_title	Vascular Health and Risk Management
authorswithroles_txt_mv	Falskov B @@aut@@ Hermann @@aut@@ Rask-Madsen @@aut@@ Major-Pedersen @@aut@@ Christiansen @@aut@@ Raunsø @@aut@@ Køber @@aut@@ Torp-Pedersen C @@aut@@ Dominguez @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
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The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. 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issn	11782048
topic_title	RC666-701 The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive Insulin resistance. Diabetes. Heart failure. Endothelial function
topic	misc RC666-701 misc Insulin resistance. Diabetes. Heart failure. Endothelial function misc Diseases of the circulatory (Cardiovascular) system
topic_unstemmed	misc RC666-701 misc Insulin resistance. Diabetes. Heart failure. Endothelial function misc Diseases of the circulatory (Cardiovascular) system
topic_browse	misc RC666-701 misc Insulin resistance. Diabetes. Heart failure. Endothelial function misc Diseases of the circulatory (Cardiovascular) system
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title	The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
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title_full	The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
author_sort	Falskov B
journal	Vascular Health and Risk Management
journalStr	Vascular Health and Risk Management
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lang_code	eng
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author_browse	Falskov B Hermann Rask-Madsen Major-Pedersen Christiansen Raunsø Køber Torp-Pedersen C Dominguez
class	RC666-701
format_se	Elektronische Aufsätze
author-letter	Falskov B
author2-role	verfasserin
title_sort	effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
callnumber	RC666-701
title_auth	The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
abstract	Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function
abstractGer	Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function
abstract_unstemmed	Britt Falskov1, Thomas Steffen Hermann1, Christian Rask-Madsen2, Atheline Major-Pedersen1, Buris Christiansen1, Jakob Raunso1, Lars Kober3, Christian Torp-Pedersen1, Helena Dominguez41Department of Cardiology, Gentofte Hospital, Denmark; 2Joslin Diabetes Center, Boston (MA), USA; 3Department of Cardiology, Rigshospitalet, Copenhagen, Denmark; 4Department of Cardiology, Herlev Hospital, Herlev, DenmarkAim: Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.Methods: Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose uptake was measured during the insulin infusion.Results: Patients with systolic heart failure had impaired insulin-stimulated endothelial function. The percentage increase in blood flow during co-infusion with insulin and serotonin dose response study was 24.74% +- 6.16%, 23.50% +- 8.32%, and 22.29% +- 10.77% at the three doses respectively, compared to the healthy control group 45.96% +- 11.56%, 67.40% +- 18.11% and 84.57% +- 25.73% (P = 0.01). Insulin-stimulated endothelial function was similar in heart failure patients and patients with type 2 diabetes, while it was further deteriorated in patients suffering from both heart failure and diabetes with a percentage increase in blood flow of 19.15% +- 7.81%, -2.35% +- 11.76%, and 5.82% +- 17.70% at the three doses of serotonin, respectively. Forearm glucose uptake was impaired in patients with heart failure compared to healthy controls (P = 0.03) and tended to be further impaired by co-existence of diabetes (P = 0.08).Conclusion: Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. The effects of systolic heart failure and type 2 diabetes appear to be additive.Keywords: insulin resistance, diabetes, heart failure, endothelial function
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title_short	The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive
url	https://doaj.org/article/d90a0d2932574bc1a5c1673be9966f4d https://www.dovepress.com/the-effect-of-chronic-heart-failure-and-type-2-diabetes-on-insulin-sti-peer-reviewed-article-VHRM https://doaj.org/toc/1178-2048
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author2	Hermann Rask-Madsen Major-Pedersen Christiansen Raunsø Køber Torp-Pedersen C Dominguez
author2Str	Hermann Rask-Madsen Major-Pedersen Christiansen Raunsø Køber Torp-Pedersen C Dominguez
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up_date	2024-07-03T20:12:01.776Z
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