Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats

Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD<sub<50</sub<) of anthraquinone was estimated to be <5000 mg/kg body weight (...
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Autor*in:	Jingjing Qu [verfasserIn] Lanjie Pei [verfasserIn] Xiangyan Wang [verfasserIn] Shaohua Fu [verfasserIn] Ling Yong [verfasserIn] Xiao Xiao [verfasserIn] Qianqian Xie [verfasserIn] Bolin Fan [verfasserIn] Yan Song [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	anthraquinone acute toxicity subchronic toxicity Sprague Dawley rats

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 19(2022), 10413, p 10413
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:10413, p 10413

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph191610413

Katalog-ID:	DOAJ036405906

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allfieldsSound	10.3390/ijerph191610413 doi (DE-627)DOAJ036405906 (DE-599)DOAJ3e4445d65ea04f0484b0b6c5a32becd5 DE-627 ger DE-627 rakwb eng Jingjing Qu verfasserin aut Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD<sub<50</sub<) of anthraquinone was estimated to be <5000 mg/kg body weight (BW). In the subchronic study, groups of 10 male and 10 female rats were dosed with anthraquinone by gavage at 0, 1.36, 5.44, 21.76, and 174.08 mg/kg BW, 7 days/week for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 1.36 mg/kg BW group. When the animals received 5.44 mg/kg BW or more of anthraquinone, hyaline droplet accumulation in the renal tubules was observed in both the male and female rats, and anemia was observed in the females. When the anthraquinone dose reached 174.08 mg/kg BW, mild hepatocellular hypertrophy around the central vein of the hepatic lobule and hypothyroidism were observed in the female rats. During the recovery period, changes in clinical symptoms and parameters were considerably alleviated. Based on the results of this study, the no observed adverse effect level (NOAEL) for anthraquinone in rats was set at 1.36 mg/kg BW, and the lowest observed adverse effect level (LOAEL) was 5.44 mg/kg BW. anthraquinone acute toxicity subchronic toxicity Sprague Dawley rats Medicine R Lanjie Pei verfasserin aut Xiangyan Wang verfasserin aut Shaohua Fu verfasserin aut Ling Yong verfasserin aut Xiao Xiao verfasserin aut Qianqian Xie verfasserin aut Bolin Fan verfasserin aut Yan Song verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 19(2022), 10413, p 10413 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:19 year:2022 number:10413, p 10413 https://doi.org/10.3390/ijerph191610413 kostenfrei https://doaj.org/article/3e4445d65ea04f0484b0b6c5a32becd5 kostenfrei https://www.mdpi.com/1660-4601/19/16/10413 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 10413, p 10413
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author	Jingjing Qu
spellingShingle	Jingjing Qu misc anthraquinone misc acute toxicity misc subchronic toxicity misc Sprague Dawley rats misc Medicine misc R Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats
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topic_title	Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats anthraquinone acute toxicity subchronic toxicity Sprague Dawley rats
topic	misc anthraquinone misc acute toxicity misc subchronic toxicity misc Sprague Dawley rats misc Medicine misc R
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title	Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats
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title_full	Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats
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title_sort	acute and subchronic oral toxicity of anthraquinone in sprague dawley rats
title_auth	Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats
abstract	Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD<sub<50</sub<) of anthraquinone was estimated to be <5000 mg/kg body weight (BW). In the subchronic study, groups of 10 male and 10 female rats were dosed with anthraquinone by gavage at 0, 1.36, 5.44, 21.76, and 174.08 mg/kg BW, 7 days/week for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 1.36 mg/kg BW group. When the animals received 5.44 mg/kg BW or more of anthraquinone, hyaline droplet accumulation in the renal tubules was observed in both the male and female rats, and anemia was observed in the females. When the anthraquinone dose reached 174.08 mg/kg BW, mild hepatocellular hypertrophy around the central vein of the hepatic lobule and hypothyroidism were observed in the female rats. During the recovery period, changes in clinical symptoms and parameters were considerably alleviated. Based on the results of this study, the no observed adverse effect level (NOAEL) for anthraquinone in rats was set at 1.36 mg/kg BW, and the lowest observed adverse effect level (LOAEL) was 5.44 mg/kg BW.
abstractGer	Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD<sub<50</sub<) of anthraquinone was estimated to be <5000 mg/kg body weight (BW). In the subchronic study, groups of 10 male and 10 female rats were dosed with anthraquinone by gavage at 0, 1.36, 5.44, 21.76, and 174.08 mg/kg BW, 7 days/week for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 1.36 mg/kg BW group. When the animals received 5.44 mg/kg BW or more of anthraquinone, hyaline droplet accumulation in the renal tubules was observed in both the male and female rats, and anemia was observed in the females. When the anthraquinone dose reached 174.08 mg/kg BW, mild hepatocellular hypertrophy around the central vein of the hepatic lobule and hypothyroidism were observed in the female rats. During the recovery period, changes in clinical symptoms and parameters were considerably alleviated. Based on the results of this study, the no observed adverse effect level (NOAEL) for anthraquinone in rats was set at 1.36 mg/kg BW, and the lowest observed adverse effect level (LOAEL) was 5.44 mg/kg BW.
abstract_unstemmed	Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD<sub<50</sub<) of anthraquinone was estimated to be <5000 mg/kg body weight (BW). In the subchronic study, groups of 10 male and 10 female rats were dosed with anthraquinone by gavage at 0, 1.36, 5.44, 21.76, and 174.08 mg/kg BW, 7 days/week for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 1.36 mg/kg BW group. When the animals received 5.44 mg/kg BW or more of anthraquinone, hyaline droplet accumulation in the renal tubules was observed in both the male and female rats, and anemia was observed in the females. When the anthraquinone dose reached 174.08 mg/kg BW, mild hepatocellular hypertrophy around the central vein of the hepatic lobule and hypothyroidism were observed in the female rats. During the recovery period, changes in clinical symptoms and parameters were considerably alleviated. Based on the results of this study, the no observed adverse effect level (NOAEL) for anthraquinone in rats was set at 1.36 mg/kg BW, and the lowest observed adverse effect level (LOAEL) was 5.44 mg/kg BW.
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title_short	Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats
url	https://doi.org/10.3390/ijerph191610413 https://doaj.org/article/3e4445d65ea04f0484b0b6c5a32becd5 https://www.mdpi.com/1660-4601/19/16/10413 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601
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author2	Lanjie Pei Xiangyan Wang Shaohua Fu Ling Yong Xiao Xiao Qianqian Xie Bolin Fan Yan Song
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up_date	2024-07-03T20:24:28.789Z
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Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats

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