Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.

<label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (AP...
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Autor*in:	Frank Schraml [verfasserIn] Kewei Chen [verfasserIn] Napatkamon Ayutyanont [verfasserIn] Roontiva Auttawut [verfasserIn] Jessica B S Langbaum [verfasserIn] Wendy Lee [verfasserIn] Xiaofen Liu [verfasserIn] Dan Bandy [verfasserIn] Stephanie Q Reeder [verfasserIn] Gene E Alexander [verfasserIn] Richard J Caselli [verfasserIn] Adam S Fleisher [verfasserIn] Eric M Reiman [verfasserIn] Alzheimer’s Disease Neuroimaging Initiative [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Übergeordnetes Werk:	In: PLoS ONE - Public Library of Science (PLoS), 2007, 8(2013), 6, p e67163
Übergeordnetes Werk:	volume:8 ; year:2013 ; number:6, p e67163

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1371/journal.pone.0067163

Katalog-ID:	DOAJ036407232

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520			\|a <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.
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700	0		\|a Jessica B S Langbaum \|e verfasserin \|4 aut
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700	0		\|a Xiaofen Liu \|e verfasserin \|4 aut
700	0		\|a Dan Bandy \|e verfasserin \|4 aut
700	0		\|a Stephanie Q Reeder \|e verfasserin \|4 aut
700	0		\|a Gene E Alexander \|e verfasserin \|4 aut
700	0		\|a Richard J Caselli \|e verfasserin \|4 aut
700	0		\|a Adam S Fleisher \|e verfasserin \|4 aut
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allfields	10.1371/journal.pone.0067163 doi (DE-627)DOAJ036407232 (DE-599)DOAJ700a91dbed794ea5b9db8ef982e21991 DE-627 ger DE-627 rakwb eng Frank Schraml verfasserin aut Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. Medicine R Science Q Kewei Chen verfasserin aut Napatkamon Ayutyanont verfasserin aut Roontiva Auttawut verfasserin aut Jessica B S Langbaum verfasserin aut Wendy Lee verfasserin aut Xiaofen Liu verfasserin aut Dan Bandy verfasserin aut Stephanie Q Reeder verfasserin aut Gene E Alexander verfasserin aut Richard J Caselli verfasserin aut Adam S Fleisher verfasserin aut Eric M Reiman verfasserin aut Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 6, p e67163 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:6, p e67163 https://doi.org/10.1371/journal.pone.0067163 kostenfrei https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 kostenfrei http://europepmc.org/articles/PMC3694066?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6, p e67163
spelling	10.1371/journal.pone.0067163 doi (DE-627)DOAJ036407232 (DE-599)DOAJ700a91dbed794ea5b9db8ef982e21991 DE-627 ger DE-627 rakwb eng Frank Schraml verfasserin aut Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. Medicine R Science Q Kewei Chen verfasserin aut Napatkamon Ayutyanont verfasserin aut Roontiva Auttawut verfasserin aut Jessica B S Langbaum verfasserin aut Wendy Lee verfasserin aut Xiaofen Liu verfasserin aut Dan Bandy verfasserin aut Stephanie Q Reeder verfasserin aut Gene E Alexander verfasserin aut Richard J Caselli verfasserin aut Adam S Fleisher verfasserin aut Eric M Reiman verfasserin aut Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 6, p e67163 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:6, p e67163 https://doi.org/10.1371/journal.pone.0067163 kostenfrei https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 kostenfrei http://europepmc.org/articles/PMC3694066?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6, p e67163
allfields_unstemmed	10.1371/journal.pone.0067163 doi (DE-627)DOAJ036407232 (DE-599)DOAJ700a91dbed794ea5b9db8ef982e21991 DE-627 ger DE-627 rakwb eng Frank Schraml verfasserin aut Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. Medicine R Science Q Kewei Chen verfasserin aut Napatkamon Ayutyanont verfasserin aut Roontiva Auttawut verfasserin aut Jessica B S Langbaum verfasserin aut Wendy Lee verfasserin aut Xiaofen Liu verfasserin aut Dan Bandy verfasserin aut Stephanie Q Reeder verfasserin aut Gene E Alexander verfasserin aut Richard J Caselli verfasserin aut Adam S Fleisher verfasserin aut Eric M Reiman verfasserin aut Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 6, p e67163 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:6, p e67163 https://doi.org/10.1371/journal.pone.0067163 kostenfrei https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 kostenfrei http://europepmc.org/articles/PMC3694066?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6, p e67163
allfieldsGer	10.1371/journal.pone.0067163 doi (DE-627)DOAJ036407232 (DE-599)DOAJ700a91dbed794ea5b9db8ef982e21991 DE-627 ger DE-627 rakwb eng Frank Schraml verfasserin aut Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. Medicine R Science Q Kewei Chen verfasserin aut Napatkamon Ayutyanont verfasserin aut Roontiva Auttawut verfasserin aut Jessica B S Langbaum verfasserin aut Wendy Lee verfasserin aut Xiaofen Liu verfasserin aut Dan Bandy verfasserin aut Stephanie Q Reeder verfasserin aut Gene E Alexander verfasserin aut Richard J Caselli verfasserin aut Adam S Fleisher verfasserin aut Eric M Reiman verfasserin aut Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 6, p e67163 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:6, p e67163 https://doi.org/10.1371/journal.pone.0067163 kostenfrei https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 kostenfrei http://europepmc.org/articles/PMC3694066?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6, p e67163
allfieldsSound	10.1371/journal.pone.0067163 doi (DE-627)DOAJ036407232 (DE-599)DOAJ700a91dbed794ea5b9db8ef982e21991 DE-627 ger DE-627 rakwb eng Frank Schraml verfasserin aut Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose. 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD. Medicine R Science Q Kewei Chen verfasserin aut Napatkamon Ayutyanont verfasserin aut Roontiva Auttawut verfasserin aut Jessica B S Langbaum verfasserin aut Wendy Lee verfasserin aut Xiaofen Liu verfasserin aut Dan Bandy verfasserin aut Stephanie Q Reeder verfasserin aut Gene E Alexander verfasserin aut Richard J Caselli verfasserin aut Adam S Fleisher verfasserin aut Eric M Reiman verfasserin aut Alzheimer’s Disease Neuroimaging Initiative verfasserin aut In PLoS ONE Public Library of Science (PLoS), 2007 8(2013), 6, p e67163 (DE-627)523574592 (DE-600)2267670-3 19326203 nnns volume:8 year:2013 number:6, p e67163 https://doi.org/10.1371/journal.pone.0067163 kostenfrei https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 kostenfrei http://europepmc.org/articles/PMC3694066?pdf=render kostenfrei https://doaj.org/toc/1932-6203 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_34 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_235 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2013 6, p e67163
language	English
source	In PLoS ONE 8(2013), 6, p e67163 volume:8 year:2013 number:6, p e67163
sourceStr	In PLoS ONE 8(2013), 6, p e67163 volume:8 year:2013 number:6, p e67163
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	PLoS ONE
authorswithroles_txt_mv	Frank Schraml @@aut@@ Kewei Chen @@aut@@ Napatkamon Ayutyanont @@aut@@ Roontiva Auttawut @@aut@@ Jessica B S Langbaum @@aut@@ Wendy Lee @@aut@@ Xiaofen Liu @@aut@@ Dan Bandy @@aut@@ Stephanie Q Reeder @@aut@@ Gene E Alexander @@aut@@ Richard J Caselli @@aut@@ Adam S Fleisher @@aut@@ Eric M Reiman @@aut@@ Alzheimer’s Disease Neuroimaging Initiative @@aut@@
publishDateDaySort_date	2013-01-01T00:00:00Z
hierarchy_top_id	523574592
id	DOAJ036407232
language_de	englisch
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author	Frank Schraml
spellingShingle	Frank Schraml misc Medicine misc R misc Science misc Q Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
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topic_title	Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose
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title	Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
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title_full	Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose
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author_browse	Frank Schraml Kewei Chen Napatkamon Ayutyanont Roontiva Auttawut Jessica B S Langbaum Wendy Lee Xiaofen Liu Dan Bandy Stephanie Q Reeder Gene E Alexander Richard J Caselli Adam S Fleisher Eric M Reiman Alzheimer’s Disease Neuroimaging Initiative
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author-letter	Frank Schraml
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title_sort	association between an alzheimer's disease-related index and apoe ε4 gene dose
title_auth	Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
abstract	<label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.
abstractGer	<label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.
abstract_unstemmed	<label<BACKGROUND</label<We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal ε4 homozygotes, heterozygotes, and non-carriers.<label<METHODS</label<An algorithm was used to characterize and compare AD-related HCIs in cognitively normal individuals, including 36 ε4 homozygotes, 46 heterozygotes, and 78 non-carriers.<label<RESULTS</label<These three groups differed significantly in their HCIs (ANOVA, p = 0.004), and there was a significant association between HCIs and gene dose (linear trend, p = 0.001).<label<CONCLUSIONS</label<The HCI is associated with three levels of genetic risk for late-onset AD. This supports the possibility of using a single FDG PET measurement to help in the preclinical detection and tracking of AD.
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title_short	Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
url	https://doi.org/10.1371/journal.pone.0067163 https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991 http://europepmc.org/articles/PMC3694066?pdf=render https://doaj.org/toc/1932-6203
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Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.

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