The interaction of inflammatory cells in granuloma faciale

Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF i...
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Gespeichert in:

Autor*in:	Takeshi Nakahara [verfasserIn] Yoichi Moroi [verfasserIn] Akari Tashiro [verfasserIn] Hiromaro Kiryu [verfasserIn] Masutaka Furue [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Übergeordnetes Werk:	In: Dermatology Reports - PAGEPress Publications, 2010, 2(2010), 2, Seite e17-e17
Übergeordnetes Werk:	volume:2 ; year:2010 ; number:2 ; pages:e17-e17

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4081/dr.2010.e17

Katalog-ID:	DOAJ03645978X

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520			\|a Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a+ dendritic cells, CD68+ histiocytes, and CD4+ and CD8+ T cells.
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allfieldsSound	10.4081/dr.2010.e17 doi (DE-627)DOAJ03645978X (DE-599)DOAJ0ef01d481fab4ea4afde91e58b6813c8 DE-627 ger DE-627 rakwb eng RL1-803 Takeshi Nakahara verfasserin aut The interaction of inflammatory cells in granuloma faciale 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a+ dendritic cells, CD68+ histiocytes, and CD4+ and CD8+ T cells. Dermatology Yoichi Moroi verfasserin aut Akari Tashiro verfasserin aut Hiromaro Kiryu verfasserin aut Masutaka Furue verfasserin aut In Dermatology Reports PAGEPress Publications, 2010 2(2010), 2, Seite e17-e17 (DE-627)63375174X (DE-600)2568735-9 20367406 nnns volume:2 year:2010 number:2 pages:e17-e17 https://doi.org/10.4081/dr.2010.e17 kostenfrei https://doaj.org/article/0ef01d481fab4ea4afde91e58b6813c8 kostenfrei http://www.pagepress.org/journals/index.php/dr/article/view/1998 kostenfrei https://doaj.org/toc/2036-7392 Journal toc kostenfrei https://doaj.org/toc/2036-7406 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2010 2 e17-e17
language	English
source	In Dermatology Reports 2(2010), 2, Seite e17-e17 volume:2 year:2010 number:2 pages:e17-e17
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authorswithroles_txt_mv	Takeshi Nakahara @@aut@@ Yoichi Moroi @@aut@@ Akari Tashiro @@aut@@ Hiromaro Kiryu @@aut@@ Masutaka Furue @@aut@@
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topic_title	RL1-803 The interaction of inflammatory cells in granuloma faciale
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title	The interaction of inflammatory cells in granuloma faciale
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title_full	The interaction of inflammatory cells in granuloma faciale
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title_sort	interaction of inflammatory cells in granuloma faciale
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title_auth	The interaction of inflammatory cells in granuloma faciale
abstract	Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a+ dendritic cells, CD68+ histiocytes, and CD4+ and CD8+ T cells.
abstractGer	Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a+ dendritic cells, CD68+ histiocytes, and CD4+ and CD8+ T cells.
abstract_unstemmed	Granuloma faciale (GF) is a rare chronic inflammatory skin disease characterized by single or multiple reddish-brown cutaneous plaques or nodules. Although this condition is benign, its clinical course is extremely chronic with poor response to therapy. The typical histopathological features of GF include vasculitis with mixed cellular infiltration; however, its etiopathogenesis remains unknown. Here, we describe the case of a 76-year-old man with GF resistant to topical steroids. Biopsy of the lesion revealed i) dense mixed inflammatory cellular infiltrates of lymphocytes, histiocytes, neutrophils, and eosinophils, ii) mild perivascular nuclear dust and swollen endothelium of blood vessels, and iii) a narrow Grenz zone beneath the epidermis. Immunohistochemical staining demonstrated mixed cellular infiltrates intermixed with CD1a+ dendritic cells, CD68+ histiocytes, and CD4+ and CD8+ T cells.
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title_short	The interaction of inflammatory cells in granuloma faciale
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up_date	2024-07-03T20:42:06.779Z
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