Immunomodulation of NK Cells by Ionizing Radiation

Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of...
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Gespeichert in:

Autor*in:	Jiarui Chen [verfasserIn] Xingyu Liu [verfasserIn] Zihang Zeng [verfasserIn] Jiali Li [verfasserIn] Yuan Luo [verfasserIn] Wenjie Sun [verfasserIn] Yan Gong [verfasserIn] Junhong Zhang [verfasserIn] Qiuji Wu [verfasserIn] Conghua Xie [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	NK cell ionizing radiation tumor immune response immunotherapy

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.00874

Katalog-ID:	DOAJ036591351

Internformat


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allfields	10.3389/fonc.2020.00874 doi (DE-627)DOAJ036591351 (DE-599)DOAJ260e53c76c73498dbdadc918f82addb7 DE-627 ger DE-627 rakwb eng RC254-282 Jiarui Chen verfasserin aut Immunomodulation of NK Cells by Ionizing Radiation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR. NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xingyu Liu verfasserin aut Zihang Zeng verfasserin aut Jiali Li verfasserin aut Yuan Luo verfasserin aut Wenjie Sun verfasserin aut Yan Gong verfasserin aut Yan Gong verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00874 kostenfrei https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
spelling	10.3389/fonc.2020.00874 doi (DE-627)DOAJ036591351 (DE-599)DOAJ260e53c76c73498dbdadc918f82addb7 DE-627 ger DE-627 rakwb eng RC254-282 Jiarui Chen verfasserin aut Immunomodulation of NK Cells by Ionizing Radiation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR. NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xingyu Liu verfasserin aut Zihang Zeng verfasserin aut Jiali Li verfasserin aut Yuan Luo verfasserin aut Wenjie Sun verfasserin aut Yan Gong verfasserin aut Yan Gong verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00874 kostenfrei https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfields_unstemmed	10.3389/fonc.2020.00874 doi (DE-627)DOAJ036591351 (DE-599)DOAJ260e53c76c73498dbdadc918f82addb7 DE-627 ger DE-627 rakwb eng RC254-282 Jiarui Chen verfasserin aut Immunomodulation of NK Cells by Ionizing Radiation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR. NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xingyu Liu verfasserin aut Zihang Zeng verfasserin aut Jiali Li verfasserin aut Yuan Luo verfasserin aut Wenjie Sun verfasserin aut Yan Gong verfasserin aut Yan Gong verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00874 kostenfrei https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsGer	10.3389/fonc.2020.00874 doi (DE-627)DOAJ036591351 (DE-599)DOAJ260e53c76c73498dbdadc918f82addb7 DE-627 ger DE-627 rakwb eng RC254-282 Jiarui Chen verfasserin aut Immunomodulation of NK Cells by Ionizing Radiation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR. NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xingyu Liu verfasserin aut Zihang Zeng verfasserin aut Jiali Li verfasserin aut Yuan Luo verfasserin aut Wenjie Sun verfasserin aut Yan Gong verfasserin aut Yan Gong verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00874 kostenfrei https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
allfieldsSound	10.3389/fonc.2020.00874 doi (DE-627)DOAJ036591351 (DE-599)DOAJ260e53c76c73498dbdadc918f82addb7 DE-627 ger DE-627 rakwb eng RC254-282 Jiarui Chen verfasserin aut Immunomodulation of NK Cells by Ionizing Radiation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR. NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xingyu Liu verfasserin aut Zihang Zeng verfasserin aut Jiali Li verfasserin aut Yuan Luo verfasserin aut Wenjie Sun verfasserin aut Yan Gong verfasserin aut Yan Gong verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Junhong Zhang verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Qiuji Wu verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut Conghua Xie verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 10(2020) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:10 year:2020 https://doi.org/10.3389/fonc.2020.00874 kostenfrei https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 kostenfrei https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2020
language	English
source	In Frontiers in Oncology 10(2020) volume:10 year:2020
sourceStr	In Frontiers in Oncology 10(2020) volume:10 year:2020
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topic_facet	NK cell ionizing radiation tumor immune response immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Jiarui Chen @@aut@@ Xingyu Liu @@aut@@ Zihang Zeng @@aut@@ Jiali Li @@aut@@ Yuan Luo @@aut@@ Wenjie Sun @@aut@@ Yan Gong @@aut@@ Junhong Zhang @@aut@@ Qiuji Wu @@aut@@ Conghua Xie @@aut@@
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callnumber-first	R - Medicine
author	Jiarui Chen
spellingShingle	Jiarui Chen misc RC254-282 misc NK cell misc ionizing radiation misc tumor misc immune response misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunomodulation of NK Cells by Ionizing Radiation
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topic_title	RC254-282 Immunomodulation of NK Cells by Ionizing Radiation NK cell ionizing radiation tumor immune response immunotherapy
topic	misc RC254-282 misc NK cell misc ionizing radiation misc tumor misc immune response misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc NK cell misc ionizing radiation misc tumor misc immune response misc immunotherapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Immunomodulation of NK Cells by Ionizing Radiation
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title_full	Immunomodulation of NK Cells by Ionizing Radiation
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author_browse	Jiarui Chen Xingyu Liu Zihang Zeng Jiali Li Yuan Luo Wenjie Sun Yan Gong Junhong Zhang Qiuji Wu Conghua Xie
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title_sort	immunomodulation of nk cells by ionizing radiation
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title_auth	Immunomodulation of NK Cells by Ionizing Radiation
abstract	Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR.
abstractGer	Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR.
abstract_unstemmed	Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions, which can be reversed by interleukin (IL)-2 pretreatment. On the other hand, NK functions may be adjusted by other immune cells and the alternated malignant cell immunogenicity under the settings of IR. Various immune cells, such as the tumor-associated macrophage (TAM), dendritic cell (DC), regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC), and tumor exhibited ligands, such as the natural killer group 2 member D ligand (NKG2DL), natural cytotoxicity receptors (NCR) ligand, TNF-related apoptosis-inducing ligand-receptor (TRAIL-R), and FAS, have been involved in this process. Better understanding the molecular basis is a promising way in which to augment NK-cell-based antitumor immunity in combination with IR.
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title_short	Immunomodulation of NK Cells by Ionizing Radiation
url	https://doi.org/10.3389/fonc.2020.00874 https://doaj.org/article/260e53c76c73498dbdadc918f82addb7 https://www.frontiersin.org/article/10.3389/fonc.2020.00874/full https://doaj.org/toc/2234-943X
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up_date	2024-07-03T21:27:03.709Z
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Immunomodulation of NK Cells by Ionizing Radiation

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