Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance

Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral blood. Vγ9Vδ2 T cells, which cannot be studied e...
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Autor*in:	Oliver Nussbaumer [verfasserIn] Martin Thurnher [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	vγ9vδ2 t cells butyrophilin cd161 cd56 gpr56

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 9(2020), 3, p 772
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:3, p 772

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells9030772

Katalog-ID:	DOAJ03667687X

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authorswithroles_txt_mv	Oliver Nussbaumer @@aut@@ Martin Thurnher @@aut@@
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callnumber-first	Q - Science
author	Oliver Nussbaumer
spellingShingle	Oliver Nussbaumer misc QH301-705.5 misc vγ9vδ2 t cells misc butyrophilin misc cd161 misc cd56 misc gpr56 misc Biology (General) Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
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topic_title	QH301-705.5 Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance vγ9vδ2 t cells butyrophilin cd161 cd56 gpr56
topic	misc QH301-705.5 misc vγ9vδ2 t cells misc butyrophilin misc cd161 misc cd56 misc gpr56 misc Biology (General)
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title	Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
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title_full	Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
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title_sort	functional phenotypes of human vγ9vδ2 t cells in lymphoid stress surveillance
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title_auth	Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
abstract	Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral blood. Vγ9Vδ2 T cells, which cannot be studied easily in vivo because they do not exist in rodents, are often referred to as innate-like T cells. The genetically recombined γδ T cell receptor (TCR) that responds to isoprenoid-derived pyrophosphates (phosphoantigens) produced by infected and malignant cells in a butyrophilin-dependent manner qualifies them as therapeutically relevant components of the adaptive immune system. On the other hand, cell-surface proteins such as the C-type lectin CD161 mark a functional phenotype of Vγ9Vδ2 T cells that mediates TCR-independent innate-like responses. Moreover, CD56 (neural cell adhesion molecule, NCAM) and the G protein-coupled receptor GPR56 define Vγ9Vδ2 T cells with increased cytolytic potential and, like CD161, may also be expressed by dendritic cells, principally facilitating the generation of an innate-like immunological synapse. In this review, we summarise current knowledge of Vγ9Vδ2 T cell functional phenotypes that are critical to lymphoid stress surveillance.
abstractGer	Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral blood. Vγ9Vδ2 T cells, which cannot be studied easily in vivo because they do not exist in rodents, are often referred to as innate-like T cells. The genetically recombined γδ T cell receptor (TCR) that responds to isoprenoid-derived pyrophosphates (phosphoantigens) produced by infected and malignant cells in a butyrophilin-dependent manner qualifies them as therapeutically relevant components of the adaptive immune system. On the other hand, cell-surface proteins such as the C-type lectin CD161 mark a functional phenotype of Vγ9Vδ2 T cells that mediates TCR-independent innate-like responses. Moreover, CD56 (neural cell adhesion molecule, NCAM) and the G protein-coupled receptor GPR56 define Vγ9Vδ2 T cells with increased cytolytic potential and, like CD161, may also be expressed by dendritic cells, principally facilitating the generation of an innate-like immunological synapse. In this review, we summarise current knowledge of Vγ9Vδ2 T cell functional phenotypes that are critical to lymphoid stress surveillance.
abstract_unstemmed	Butyrophilin and butyrophilin-like proteins select γδ T cells and direct the migration of γδ T cell subsets to distinct anatomical sites. γδ T cells expressing Vδ2 paired with Vγ9 (Vγ9Vδ2 T cells) are the predominant γδ T cell type in human peripheral blood. Vγ9Vδ2 T cells, which cannot be studied easily in vivo because they do not exist in rodents, are often referred to as innate-like T cells. The genetically recombined γδ T cell receptor (TCR) that responds to isoprenoid-derived pyrophosphates (phosphoantigens) produced by infected and malignant cells in a butyrophilin-dependent manner qualifies them as therapeutically relevant components of the adaptive immune system. On the other hand, cell-surface proteins such as the C-type lectin CD161 mark a functional phenotype of Vγ9Vδ2 T cells that mediates TCR-independent innate-like responses. Moreover, CD56 (neural cell adhesion molecule, NCAM) and the G protein-coupled receptor GPR56 define Vγ9Vδ2 T cells with increased cytolytic potential and, like CD161, may also be expressed by dendritic cells, principally facilitating the generation of an innate-like immunological synapse. In this review, we summarise current knowledge of Vγ9Vδ2 T cell functional phenotypes that are critical to lymphoid stress surveillance.
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title_short	Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance
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Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance

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