RNA Interference as a Prospective Tool for the Control of Human Viral Infections

RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevert...
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Autor*in:	Alesia Levanova [verfasserIn] Minna M. Poranen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	RNA interference antiviral siRNA antiviral shRNA siRNA production siRNA delivery

Übergeordnetes Werk:	In: Frontiers in Microbiology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmicb.2018.02151

Katalog-ID:	DOAJ036717460

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callnumber-first	Q - Science
author	Alesia Levanova
spellingShingle	Alesia Levanova misc QR1-502 misc RNA interference misc antiviral siRNA misc antiviral shRNA misc siRNA production misc siRNA delivery misc Microbiology RNA Interference as a Prospective Tool for the Control of Human Viral Infections
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topic_title	QR1-502 RNA Interference as a Prospective Tool for the Control of Human Viral Infections RNA interference antiviral siRNA antiviral shRNA siRNA production siRNA delivery
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title	RNA Interference as a Prospective Tool for the Control of Human Viral Infections
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title_full	RNA Interference as a Prospective Tool for the Control of Human Viral Infections
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title_sort	rna interference as a prospective tool for the control of human viral infections
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title_auth	RNA Interference as a Prospective Tool for the Control of Human Viral Infections
abstract	RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
abstractGer	RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
abstract_unstemmed	RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates. Whether RNAi naturally protects humans from viral invasion is still a matter of debate. Nevertheless, exogenous siRNAs are able to halt viral infection in mammals. The current review critically evaluates the production of antiviral siRNAs, delivery techniques to the infection sites, as well as provides an overview of antiviral siRNAs in clinical trials.
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title_short	RNA Interference as a Prospective Tool for the Control of Human Viral Infections
url	https://doi.org/10.3389/fmicb.2018.02151 https://doaj.org/article/623646cb65a149c7a287ba13e418d767 https://www.frontiersin.org/article/10.3389/fmicb.2018.02151/full https://doaj.org/toc/1664-302X
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up_date	2024-07-03T22:07:10.938Z
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