Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment

Carbon nanostructures (CN) are emerging valuable materials for the assembly of highly engineered multifunctional nanovehicles for cancer therapy, in particular for counteracting the insurgence of multi-drug resistance (MDR). In this regard, carbon nanotubes (CNT), graphene oxide (GO), and fullerenes...
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Autor*in:	Manuela Curcio [verfasserIn] Annafranca Farfalla [verfasserIn] Federica Saletta [verfasserIn] Emanuele Valli [verfasserIn] Elvira Pantuso [verfasserIn] Fiore Pasquale Nicoletta [verfasserIn] Francesca Iemma [verfasserIn] Orazio Vittorio [verfasserIn] Giuseppe Cirillo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	carbon nanostructures carbon nanohybrids cancer therapy multi-drug resistance

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 25(2020), 9, p 2102
Übergeordnetes Werk:	volume:25 ; year:2020 ; number:9, p 2102

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules25092102

Katalog-ID:	DOAJ036737593

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language	English
source	In Molecules 25(2020), 9, p 2102 volume:25 year:2020 number:9, p 2102
sourceStr	In Molecules 25(2020), 9, p 2102 volume:25 year:2020 number:9, p 2102
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institution	findex.gbv.de
topic_facet	carbon nanostructures carbon nanohybrids cancer therapy multi-drug resistance Organic chemistry
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authorswithroles_txt_mv	Manuela Curcio @@aut@@ Annafranca Farfalla @@aut@@ Federica Saletta @@aut@@ Emanuele Valli @@aut@@ Elvira Pantuso @@aut@@ Fiore Pasquale Nicoletta @@aut@@ Francesca Iemma @@aut@@ Orazio Vittorio @@aut@@ Giuseppe Cirillo @@aut@@
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callnumber-first	Q - Science
author	Manuela Curcio
spellingShingle	Manuela Curcio misc QD241-441 misc carbon nanostructures misc carbon nanohybrids misc cancer therapy misc multi-drug resistance misc Organic chemistry Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment
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topic_title	QD241-441 Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment carbon nanostructures carbon nanohybrids cancer therapy multi-drug resistance
topic	misc QD241-441 misc carbon nanostructures misc carbon nanohybrids misc cancer therapy misc multi-drug resistance misc Organic chemistry
topic_unstemmed	misc QD241-441 misc carbon nanostructures misc carbon nanohybrids misc cancer therapy misc multi-drug resistance misc Organic chemistry
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title	Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment
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title_full	Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment
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title_sort	functionalized carbon nanostructures versus drug resistance: promising scenarios in cancer treatment
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title_auth	Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment
abstract	Carbon nanostructures (CN) are emerging valuable materials for the assembly of highly engineered multifunctional nanovehicles for cancer therapy, in particular for counteracting the insurgence of multi-drug resistance (MDR). In this regard, carbon nanotubes (CNT), graphene oxide (GO), and fullerenes (F) have been proposed as promising materials due to their superior physical, chemical, and biological features. The possibility to easily modify their surface, conferring tailored properties, allows different CN derivatives to be synthesized. Although many studies have explored this topic, a comprehensive review evaluating the beneficial use of functionalized CNT vs G or F is still missing. Within this paper, the most relevant examples of CN-based nanosystems proposed for MDR reversal are reviewed, taking into consideration the functionalization routes, as well as the biological mechanisms involved and the possible toxicity concerns. The main aim is to understand which functional CN represents the most promising strategy to be further investigated for overcoming MDR in cancer.
abstractGer	Carbon nanostructures (CN) are emerging valuable materials for the assembly of highly engineered multifunctional nanovehicles for cancer therapy, in particular for counteracting the insurgence of multi-drug resistance (MDR). In this regard, carbon nanotubes (CNT), graphene oxide (GO), and fullerenes (F) have been proposed as promising materials due to their superior physical, chemical, and biological features. The possibility to easily modify their surface, conferring tailored properties, allows different CN derivatives to be synthesized. Although many studies have explored this topic, a comprehensive review evaluating the beneficial use of functionalized CNT vs G or F is still missing. Within this paper, the most relevant examples of CN-based nanosystems proposed for MDR reversal are reviewed, taking into consideration the functionalization routes, as well as the biological mechanisms involved and the possible toxicity concerns. The main aim is to understand which functional CN represents the most promising strategy to be further investigated for overcoming MDR in cancer.
abstract_unstemmed	Carbon nanostructures (CN) are emerging valuable materials for the assembly of highly engineered multifunctional nanovehicles for cancer therapy, in particular for counteracting the insurgence of multi-drug resistance (MDR). In this regard, carbon nanotubes (CNT), graphene oxide (GO), and fullerenes (F) have been proposed as promising materials due to their superior physical, chemical, and biological features. The possibility to easily modify their surface, conferring tailored properties, allows different CN derivatives to be synthesized. Although many studies have explored this topic, a comprehensive review evaluating the beneficial use of functionalized CNT vs G or F is still missing. Within this paper, the most relevant examples of CN-based nanosystems proposed for MDR reversal are reviewed, taking into consideration the functionalization routes, as well as the biological mechanisms involved and the possible toxicity concerns. The main aim is to understand which functional CN represents the most promising strategy to be further investigated for overcoming MDR in cancer.
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title_short	Functionalized Carbon Nanostructures Versus Drug Resistance: Promising Scenarios in Cancer Treatment
url	https://doi.org/10.3390/molecules25092102 https://doaj.org/article/889fd3195a29474d9a9f67b48bf15c2a https://www.mdpi.com/1420-3049/25/9/2102 https://doaj.org/toc/1420-3049
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up_date	2024-07-03T22:13:21.014Z
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